Guangzhe Li
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View article: Semantic repurposing model for traditional Chinese ancient formulas based on a knowledge graph
Semantic repurposing model for traditional Chinese ancient formulas based on a knowledge graph Open
A knowledge-graph-based semantic repurposing model is proposed for drug repositioning of multi-compound and -component prescriptions. This approach serves as a novel tool for developing drugs based on TCM formulas.
View article: Unveiling the power of Pueraria lobata: a comprehensive exploration of its medicinal and edible potentials
Unveiling the power of Pueraria lobata: a comprehensive exploration of its medicinal and edible potentials Open
Background Pueraria lobata (Willd.) Ohwi, a perennial vine native to China, has significant medicinal and edible value. Its roots are used as medicine and are known as kudzu (Chinese: Gegen ) and were first recorded in Shen Nong Ben Cao Ji…
View article: Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non‐Small Cell Lung Cancer
Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non‐Small Cell Lung Cancer Open
Non‐small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Ginsenosides have been shown to have strong antitumor activity, inhibiting tumor cell growth and promoting apoptosis. In this paper, the effects of …
View article: Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex
Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex Open
The tumor microenvironment (TME) severely limits the efficacy of clinical applications of photodynamic therapy (PDT). The development of a functional agent allowing full use of the TME to boost synergistic PDT and ferroptosis anti‐tumor ef…
View article: Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy
Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy Open
The ability of photosensitizers (PSs) to generate reactive oxygen species (ROS) is crucial for photodynamic therapy (PDT). However, many traditional PSs face the drawbacks that aggregation-caused quenching (ACQ) and highly expressed glutat…
View article: Synergistic effect in the co-extraction of Ginseng and Schisandra protein
Synergistic effect in the co-extraction of Ginseng and Schisandra protein Open
Introduction Ginseng and Schisandra are traditional Chinese plants that have been used in culinary practices and are renowned for their immune-boosting properties. In Chinese medicine, Ginseng and Schisandra are frequently used together as…
View article: Review on active components and mechanism of natural product polysaccharides against gastric carcinoma
Review on active components and mechanism of natural product polysaccharides against gastric carcinoma Open
View article: Spatiotemporal Controllable Sono‐Nanovaccines Driven by Free‐Field Based Whole‐Body Ultrasound for Personalized Cancer Therapy
Spatiotemporal Controllable Sono‐Nanovaccines Driven by Free‐Field Based Whole‐Body Ultrasound for Personalized Cancer Therapy Open
Therapeutic cancer vaccines fail to produce satisfactory outcomes against solid tumors since vaccine‐induced anti‐tumor immunity is significantly hampered by immunosuppression. Generating an in situ cancer vaccine targeting immunological c…
View article: An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity
An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity Open
Photodynamic therapy (PDT) has garnered significant attention in the fields of cancer treatment and drug-resistant bacteria eradication due to its non-invasive nature and spatiotemporal controllability. Iridium complexes have captivated re…
View article: An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity
An AIE Metal Iridium Complex: Photophysical Properties and Singlet Oxygen Generation Capacity Open
Photodynamic therapy (PDT) has garnered significant attention in the fields of cancer treatment and drug-resistant bacteria eradication due to its non-invasive nature and spatiotemporal controllability. Iridium complexes have captivated re…
View article: Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review
Ethnic, Botanic, Phytochemistry and Pharmacology of the Acorus L. Genus: A Review Open
The genus Acorus, a perennial monocotyledonous-class herb and part of the Acoraceae family, is widely distributed in the temperate and subtropical zones of the Northern and Southern Hemispheres. Acorus is rich in biological activities and …
View article: Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems
Biological interactions of polystyrene nanoplastics: Their cytotoxic and immunotoxic effects on the hepatic and enteric systems Open
As emerging pollutants in the environment, nanoplastics (NPs) can cross biological barriers and be enriched in organisms, posing a greatest threat to the health of livestock and humans. However, the size-dependent toxic effects of NPs in h…
View article: Immunomodulatory activity of semen Ziziphi Spinosae protein: a potential plant protein functional food raw material
Immunomodulatory activity of semen Ziziphi Spinosae protein: a potential plant protein functional food raw material Open
Semen Ziziphi Spinosae protein (SZSP) is a new plant protein resource with good food functional properties and health care function. However, the biological activity of SZSP has not been further studied, which greatly limits the developmen…
View article: Yuhong ointment ameliorates inflammatory responses and wound healing in scalded mice
Yuhong ointment ameliorates inflammatory responses and wound healing in scalded mice Open
In this work, the active ingredients of YHO were identified via HPLC and HPLC-MS analysis. Importantly, YHO showed great advantages in transdermal delivery and scald wound healing, which can be attributed to the both anti-inflammatory and …
View article: Self-assembled nanoparticles based on cationic mono-/AIE tetra-nuclear Ir(<scp>iii</scp>) complexes: long wavelength absorption/near-infrared emission photosensitizers for photodynamic therapy
Self-assembled nanoparticles based on cationic mono-/AIE tetra-nuclear Ir(<span>iii</span>) complexes: long wavelength absorption/near-infrared emission photosensitizers for photodynamic therapy Open
New cationic mono- and AIE tetra-nuclear Ir( iii ) complex-porphyrin conjugates and the corresponding carrier-free NP PSs by self-assembly methods without any auxiliary reagents, [TPP-Ir]+ NPs and [TPP-4Ir]4+ NPs, are obtained for highly e…
View article: Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomnia via activation of GABAA receptor
Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomnia via activation of GABAA receptor Open
Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F . Chow [Rhamnaceae; Ziziphi Spinosae Semen (ZSS)] has attracted extensive attention as the first choice of traditional Chinese medicine in the treatment of insomnia. However, recent studies on…
View article: Paraburkholderia sp. GD17 improves tomato plant growth and resistance to Botrytis cinerea-induced disease
Paraburkholderia sp. GD17 improves tomato plant growth and resistance to Botrytis cinerea-induced disease Open
Background and aims The plant growth promoting rhizobacteria have been repeatedly addressed in improving plant growth and resistance against pathogens. This study explored the role of Paraburkholderia sp. GD17 in improving tomato plant gro…
View article: Neuroprotective effect of Ziziphi Spinosae Semen on p-chlorophenylalanine induced insomnia rats by activating GABA A receptor
Neuroprotective effect of Ziziphi Spinosae Semen on p-chlorophenylalanine induced insomnia rats by activating GABA A receptor Open
Ziziphi Spinosae Semen (ZSS), as the first choice of traditional Chinese medicine in the treatment of insomnia, has attracted extensive attention. However, the current studies on improving sleep mechanism of ZSS are mainly focused on the r…
View article: Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release
Salmonella Induces the cGAS-STING-Dependent Type I Interferon Response in Murine Macrophages by Triggering mtDNA Release Open
As one of the most common foodborne transmitted zoonotic pathogens, S. Typhimurium infection causes diarrheal disease in humans and animals. S. Typhimurium infection has been implicated as an inducer for the type I interferon (IFN) respons…
View article: Physico‐chemical properties, antioxidant activity, and ACE inhibitory activity of protein hydrolysates from wild jujube seed
Physico‐chemical properties, antioxidant activity, and ACE inhibitory activity of protein hydrolysates from wild jujube seed Open
Wild jujube seed protein (WJSP) as one kind of functional food material has attracted much attention due to its highly nutritive and medicinal value in anti‐inflammatory and improving immunomodulatory ability. However, owing to its large m…
View article: Novel Water-Soluble Chlorin-Based Photosensitizer for Low-Fluence Photodynamic Therapy
Novel Water-Soluble Chlorin-Based Photosensitizer for Low-Fluence Photodynamic Therapy Open
Photodynamic therapy (PDT), performed with low-fluence rates, can improve antitumor responses and prevent adverse effects. However, photosensitizers (PSs) for low-fluence PDT treatment are rarely reported. Herein, we exploited an amphiphil…
View article: Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis
Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis Open
View article: AIE-active iridium(<scp>iii</scp>) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy
AIE-active iridium(<span>iii</span>) complex integrated with upconversion nanoparticles for NIR-irradiated photodynamic therapy Open
The integration of an aggregation induced emission (AIE)-active Ir( iii ) complex and upconversion nanoparticles (UCNPs) has achieved a NIR-irradiated photosensitizer (PS), UCNPs@Ir-2-N, for photodynamic therapy (PDT) applications.
View article: Biological Interactions of Polystyrene Nanoplastics: Their Cytotoxic and Immunotoxic Effects on the Hepatic and Enteric Systems
Biological Interactions of Polystyrene Nanoplastics: Their Cytotoxic and Immunotoxic Effects on the Hepatic and Enteric Systems Open
View article: AIE-active Ir(<scp>iii</scp>) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy
AIE-active Ir(<span>iii</span>) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy Open
Two AIE-active Ir( iii ) cationic complexes containing Schiff base ligands were synthesised. Ir-2-N+ NPs are shown to be good PSs in vitro for PDT.
View article: Degradation of amyloid peptide aggregates by targeted singlet oxygen delivery from a benzothiazole functionalized naphthalene endoperoxide
Degradation of amyloid peptide aggregates by targeted singlet oxygen delivery from a benzothiazole functionalized naphthalene endoperoxide Open
The endoperoxide form (BZTN-O2) of the naphthalene–benzothiazole conjugate successfully inhibited and/or reversed amyloid aggregation.
View article: An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression
An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression Open
The “molecular machine” C34 could suppress tumor systemically via unimolecule-mediated sono/immunotherapy.
View article: Compound Traditional Chinese Medicine Dermatitis Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules in AD
Compound Traditional Chinese Medicine Dermatitis Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules in AD Open
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by an itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) is a traditional classics aimed at AD composed of a mixtur…
View article: Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy
Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy Open
View article: Paraburkholderia sp. GD17 improves rice seedling tolerance to salinity
Paraburkholderia sp. GD17 improves rice seedling tolerance to salinity Open
Background and aims The plant growth promoting rhizobacteria have been extensively implicated in plant responses to changing environments. However, the action mechanisms still need to be elucidated. This study addressed the effect of Para…