Qiling Xu
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View article: Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease
Preclinical ex vivo IL2RG gene therapy using autologous hematopoietic stem cells as an effective and safe treatment for X-linked severe combined immunodeficiency disease Open
X-linked severe combined immunodeficiency disease (X-SCID) is a rare inherited disease caused by mutations in the interleukin 2 receptor subunit gamma gene (IL2RG), which encodes the common γ chain protein, a subunit of the receptor…
View article: Comparative effect of different mindfulness-based intervention types and deliveries on depression in patients with breast cancer: a protocol for a systematic review and network meta-analysis
Comparative effect of different mindfulness-based intervention types and deliveries on depression in patients with breast cancer: a protocol for a systematic review and network meta-analysis Open
Introduction Breast cancer has become the most common cancer worldwide. Various types of mindfulness-based interventions (e.g., mindfulness-based cognitive therapy, mindfulness-based stress reduction) have been conducted in different deliv…
View article: Application of Failure Mode and Effects Analysis (FMEA) to Optimize Acute Kidney Injury Management Process- a multicenter study in China
Application of Failure Mode and Effects Analysis (FMEA) to Optimize Acute Kidney Injury Management Process- a multicenter study in China Open
Background Acute kidney injury (AKI) occurs frequently in the healthcare setting, especially in the hospital across all departments, often misdiagnosed and inappropriately worked up of AKI which causes severe consequences. This study aims …
View article: Comparison of the efficacy and tolerability of different repetitive transcranial magnetic stimulation modalities for post-stroke dysphagia: a systematic review and Bayesian network meta-analysis protocol
Comparison of the efficacy and tolerability of different repetitive transcranial magnetic stimulation modalities for post-stroke dysphagia: a systematic review and Bayesian network meta-analysis protocol Open
Introduction Up to 78% of patients who had a stroke develop post-stroke dysphagia (PSD), a significant consequence. Life-threatening aspiration pneumonia, starvation, and water and electrolyte abnormalities can result. Several meta-analyse…
View article: Effect of robot-assisted gait training on motor dysfunction in Parkinson’s patients:A systematic review and meta-analysis
Effect of robot-assisted gait training on motor dysfunction in Parkinson’s patients:A systematic review and meta-analysis Open
BACKGROUND: Robot-assisted gait training (RAGT) has been reported to treat motor dysfunction in patients with Parkinson’s disease (PD) in the last few years. However, the benefits of RAGT for treating motor dysfunction in PD are still uncl…
View article: Directed evolution of a keratinase BLk from Bacillus licheniformis to enhance the solvent tolerance
Directed evolution of a keratinase BLk from Bacillus licheniformis to enhance the solvent tolerance Open
Keratinase, an important protein used in hair degradation, requires stability enhancement in industrial applications due to the harsh reaction environment for keratin hydrolysis. Previous studies have focused on improving the thermostabili…
View article: Adverse reactions after treatment with dasatinib in chronic myeloid leukemia: Characteristics, potential mechanisms, and clinical management strategies
Adverse reactions after treatment with dasatinib in chronic myeloid leukemia: Characteristics, potential mechanisms, and clinical management strategies Open
Dasatinib, a second-generation tyrosine kinase inhibitor, is recommended as first-line treatment for patients newly diagnosed with chronic myeloid leukemia (CML) and second-line treatment for those who are resistant or intolerant to therap…
View article: Dual novel homozygous mutations in ISG15 and MPO lead to classic type I interferonopathy and a new phenotype of recurrent parenchymal pneumonia
Dual novel homozygous mutations in ISG15 and MPO lead to classic type I interferonopathy and a new phenotype of recurrent parenchymal pneumonia Open
Purpose ISG15 deficiency, a rare human inborn error of immunity characterized by susceptibility to Mycobacterium tuberculosis infection, shows neuropathic and dermatological manifestations. MPO deficiency is a common inherited defect of ph…
View article: Safety monitoring in inactivated COVID-19 vaccines by clinical pharmacists from a single center in China
Safety monitoring in inactivated COVID-19 vaccines by clinical pharmacists from a single center in China Open
Given that vaccine-induced adverse effects were mostly based on previous laboratory research and clinical trials, real-world data on the safety of coronavirus disease 2019 (COVID-19) vaccination were lacking. This study reported the advers…
View article: Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan
Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan Open
To address questions of stem cell diversity during skeletal myogenesis, a Brainbow-like genetic cell lineage tracing method, dubbed Musclebow2, was derived by enhancer trapping in zebrafish. It is shown that, after initial formation of the…
View article: Generation of human induced pluripotent stem cell line from peripheral blood mononuclear cells from an activated phosphoinositide 3-kinase δ syndrome patient
Generation of human induced pluripotent stem cell line from peripheral blood mononuclear cells from an activated phosphoinositide 3-kinase δ syndrome patient Open
View article: Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan
Clonal behaviour of myogenic precursor cells throughout the vertebrate lifespan Open
To address questions of stem cell diversity during skeletal myogenesis, a Brainbow-like genetic cell lineage tracing method, dubbed Musclebow , was derived by enhancer trapping in zebrafish. It is shown that at least 15 muscle precursor ce…
View article: Efficacy and Safety of Thalidomide As a Pre-Medication of Chemotherapy-Induced Nausea and Vomiting (CINV) Following Highly Emetogenic Chemotherapy (HEC): A Systematic Review and Meta-Analysis
Efficacy and Safety of Thalidomide As a Pre-Medication of Chemotherapy-Induced Nausea and Vomiting (CINV) Following Highly Emetogenic Chemotherapy (HEC): A Systematic Review and Meta-Analysis Open
Background In China, thalidomide (THD) has been used to prevent chemotherapy-induced nausea and vomiting (CINV) following highly emetogenic chemotherapy (HEC); however, there is limited evidence on the efficacy and safety of THD in this se…
View article: Knowledge, Attitudes, And Practices Towards Cancer Pain Management Amongst Healthcare Workers (Physicians, Pharmacists, And Nurses): A Cross-Sectional Study From First-Tier Cities in China
Knowledge, Attitudes, And Practices Towards Cancer Pain Management Amongst Healthcare Workers (Physicians, Pharmacists, And Nurses): A Cross-Sectional Study From First-Tier Cities in China Open
Purpose China is currently one of the countries with the largest increased number of new cancer cases in the world, but cancer pain management (CPM) is still inadequate. This study, through a questionnaire designed to show the knowledge, a…
View article: 604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation
604 DNA dioxygenases TET regulate keratin gene expression and enhancer networks within lineage-specific gene loci during epidermal and hair follicle-specific keratinocyte differentiation Open
View article: The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients
The role of probiotics in coronavirus disease-19 infection in Wuhan: A retrospective study of 311 severe patients Open
View article: <p>Analysis of Influencing Factors and Pharmaceutical Care of Patients with COVID-19 in Fangcang Shelter Hospital</p>
Analysis of Influencing Factors and Pharmaceutical Care of Patients with COVID-19 in Fangcang Shelter Hospital Open
Most patients with mild illness were treated with antiviral, antibiotic, and Chinese medicine therapy. However, attention should be paid to patients with mild illness presenting with hypertension and low lymphocyte count at the onset; thes…
View article: Enteric glia as a source of neural progenitors in adult zebrafish
Enteric glia as a source of neural progenitors in adult zebrafish Open
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here, we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphologica…
View article: NCK1-AS1 enhances glioma cell proliferation, radioresistance and chemoresistance via miR-22-3p/IGF1R ceRNA pathway
NCK1-AS1 enhances glioma cell proliferation, radioresistance and chemoresistance via miR-22-3p/IGF1R ceRNA pathway Open
Glioma is the deadliest disease in human central nerve system. Abnormal expression of long noncoding RNA (lncRNA) expression has been demontrated to be implicated in various cancers. The oncogenic role of lncRNA NCK1-AS1 has been validated…
View article: Author response: Enteric glia as a source of neural progenitors in adult zebrafish
Author response: Enteric glia as a source of neural progenitors in adult zebrafish Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The presence and identity of neural progen…
View article: “Enteric glia as a source of neural progenitors in adult zebrafish”
“Enteric glia as a source of neural progenitors in adult zebrafish” Open
The presence and identity of neural progenitors in the enteric nervous system (ENS) of vertebrates is a matter of intense debate. Here we demonstrate that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological…
View article: Role of SHIP2 in cell repulsion regulated by Eph receptor and ephrin signaling
Role of SHIP2 in cell repulsion regulated by Eph receptor and ephrin signaling Open
SUMMARY Previous studies have found that activation of EphB2 and ephrinB1 that drives cell segregation leads to phosphorylation of the phosphoinositide phosphatase SHIP2 downstream of forward (EphB2) but not reverse (ephrinB1) signaling. W…
View article: Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness
Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness Open
The segregation of cells with distinct regional identity underlies formation of a sharp border, which in some tissues serves to organise a boundary signaling centre. It is unclear whether or how border sharpness is coordinated with inducti…
View article: Author response: Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness
Author response: Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness Open
View article: Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness
Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness Open
Summary The segregation of cells with distinct regional identity underlies formation of a sharp border, which in some tissues serves to organise a boundary signaling centre. It is unclear whether or how border sharpness is coordinated with…
View article: Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation
Role of forward and reverse signaling in Eph receptor and ephrin mediated cell segregation Open
View article: Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain
Cell Identity Switching Regulated by Retinoic Acid Signaling Maintains Homogeneous Segments in the Hindbrain Open
View article: Cell segregation and border sharpening by Eph receptor–ephrin-mediated heterotypic repulsion
Cell segregation and border sharpening by Eph receptor–ephrin-mediated heterotypic repulsion Open
Eph receptor and ephrin signalling has a major role in cell segregation and border formation, and may act through regulation of cell adhesion, repulsion or tension. To elucidate roles of cell repulsion and adhesion, we combined experiments…
View article: Efficacy and Safety of Everolimus for Maintenance Immunosuppression of Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials
Efficacy and Safety of Everolimus for Maintenance Immunosuppression of Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials Open
Conversion from CNI to everolimus after kidney transplantation is associated with improved renal function in the first 5 years posttransplant but increases the risk of acute rejection at 1 year posttransplant and may not be well endured.