Qi-Long Hu
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View article: Development of Novel <sup>18</sup> F-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography
Development of Novel <sup>18</sup> F-Labeled Selective Orexin-2 Receptor Radioligands for Positron Emission Tomography Open
The orexin-2 receptor (OX2R), a G protein-coupled receptor activated by the neuropeptides, orexin A and B, plays an integral role in orchestrating motivation, feeding behavior, and the sleep-wake cycle. Pharmacological modulation of OX2R h…
View article: Synthesis and In Vitro Characterization of [<sup>3</sup>H]OGA-2506 as a High Affinity Radioligand for O-GlcNAcase
Synthesis and In Vitro Characterization of [<sup>3</sup>H]OGA-2506 as a High Affinity Radioligand for O-GlcNAcase Open
O-GlcNAcase (OGA) is a glycoside hydrolase that regulates protein O-GlcNAcylation, a dynamic post-translational modification implicated in numerous cellular processes. Dysregulation of OGA alters cellular O-GlcNAc homeostasis and has been …
View article: Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders
Novel Cyclic Peptides as Interleukin-23 Inhibitor for Treating Inflammatory Disorders Open
This patent application illustrates a series of cyclic peptides inhibiting Interleukin-23 (IL-23), as represented by Formula I. These cyclic peptides exhibit significant therapeutic potential for treating diseases and disorders associated …
View article: Radiosynthesis and evaluation of an 18F-labeled radioligand for imaging metabotropic glutamate receptor 3 with positron emission tomography
Radiosynthesis and evaluation of an 18F-labeled radioligand for imaging metabotropic glutamate receptor 3 with positron emission tomography Open
The metabotropic glutamate receptor 3 (mGluR3) is a G-protein-coupled receptor (GPCR) involved in modulating glutamatergic neurotransmission and maintaining neural homeostasis. By inhibiting adenylyl cyclase activity, mGluR3 negatively mod…
View article: Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase
Radiosynthesis and evaluation of a carbon-11 labeled PET ligand for imaging of O-GlcNAcase Open
O-GlcNAcase (OGA) is a key enzyme involved in regulating the dynamic cycling of O-GlcNAc modifications on intracellular proteins. OGA has emerged as a promising therapeutic target for neurodegenerative diseases, including Alzheimer's disea…
View article: CD45-targeted PET enables the visualization of inflammatory conditions
CD45-targeted PET enables the visualization of inflammatory conditions Open
Inflammation is a major contributor to human mortality, accounting for over 50% of deaths worldwide. Therefore, there is an urgent need for early and accurate diagnostic methods. PET imaging targeting leukocyte common antigen CD45 presents…
View article: CAIX-targeted PET imaging agents based on acetazolamide small molecule for clear cell renal cell carcinoma
CAIX-targeted PET imaging agents based on acetazolamide small molecule for clear cell renal cell carcinoma Open
Clear cell renal cell carcinoma (ccRCC), accounting for 65%-70%, is the most common subtype of renal cell cancers. Contrast-enhanced CT and MRI are still the predominant diagnostic modalities for renal carcinoma in clinical practice, but t…
View article: Polyoxometalate catalysts for the synthesis of N-heterocycles
Polyoxometalate catalysts for the synthesis of N-heterocycles Open
N-Heterocycle compounds are crucial scaffolds in natural products, synthetic molecules, agricultural chemicals, and pharmaceuticals. Hence, green catalytic systems for the synthesis of N-heterocycles have been widely researched in organic …
View article: CCDC 2086564: Experimental Crystal Structure Determination
CCDC 2086564: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2086563: Experimental Crystal Structure Determination
CCDC 2086563: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cleavable and tunable cysteine-specific arylation modification with aryl thioethers
Cleavable and tunable cysteine-specific arylation modification with aryl thioethers Open
A cleavable and tunable covalent modification approach for cysteine by aryl thioethers via a SNAr approach was developed. The highly efficient and selective bioconjugation reactions can proceed under the mild and biocompatible conditions.
View article: Pulmonary oligometastases treated by stereotactic body radiation therapy (SBRT): a single institution’s experience
Pulmonary oligometastases treated by stereotactic body radiation therapy (SBRT): a single institution’s experience Open
SBRT is feasible for pulmonary oligometastasis with favorable local control and minimal toxicity. Multiple dose parameters, instead of a prescription dose only, in combination with clinical parameters, should be considered for optimal loca…
View article: Silanol: a bifunctional group for peptide synthesis and late-stage functionalization
Silanol: a bifunctional group for peptide synthesis and late-stage functionalization Open
Efficient Pd-catalyzed ortho-olefination of Tyr residues by employing silanol as a directing group with high chemo- and site-selectivity was developed. Orthogonal protection strategies were also successfully applied to SPPS.