Explanipedia

CAMK2-NR4A1 signaling initiates metabolic substrate switching to induce heart failure with reduced ejection fraction Open

Alireza Saadatmand, Mark E. Pepin, Zihao Chen, Joshua Hartmann, Qiang Sun , et al. · 2025

Heart failure with reduced ejection fraction (HFrEF) is marked by a shift in cardiac energy metabolism from fatty acid oxidation to glucose utilization. This “fuel switch” promotes accumulation of glucose byproducts that modify calcium-han…

Evidence of fructose metabolism in colorectal cancer Open

Giuseppe Sica, Julia Bischof, Lukas Funke, Hartmut Juhl, Eleonora Candi , et al. · 2025

Construction and validation of a cell-in-cell related prognostic signature for hepatocellular carcinoma Open

Hao Zhong, Dong Wang, Yisheng Chen, Dejin Zhan, Chenxi Wang , et al. · 2025

USP14 promotes osteoarthritis progression by deubiquitinating FZD8 to activate the Wnt/β-catenin signaling pathway Open

Xiaochao Chen, Tiancheng Ma, Yongfeng Chen, Qiang Sun, Huayi Wang , et al. · 2025

USP14 repressed IL-1β-treated chondrocyte proliferation and promoted apoptosis, inflammation and ECM degradation by regulating FZD8 expression and Wnt/β-catenin signal pathway.

CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy Open

Xinyue Gao, Feichang Liu, Bo Zhang, Tianyi Ren, You Zheng , et al. · 2025

Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell cycle phase transitions and essential components of the checkpoint machinery involved in DNA damage response. Emerging evidence indicates the oncogenic potenti…

Modified Xi-Jiao-Di-Huang Decoction Alleviates Sepsis via Regulating Macrophage Polarization by Inhibiting the PIM2/NF-κB Pathway Open

Fan Ge, Fang Tian, Yan Zhu, Qin Yan, Qiang Sun , et al. · 2025

MXJDH regulates macrophage polarization, inhibits CRS, and alleviates sepsis by inhibiting the Pim2/NF-κB signaling pathway.

Skeletal muscle stem cells modulate niche function in Duchenne muscular dystrophy mouse through YY1-CCL5 axis Open

Yang Li, Chuhan Li, Qiang Sun, Xingyuan Liu, Fengyuan Chen , et al. · 2025

Early attainment of 20-hydroxyecdysone threshold shapes mosquito sexual dimorphism in developmental timing Open

Meichun Zhang, Han Wen, Qiang Sun, Dongjing Zhang, Yongjun Li , et al. · 2025

In holometabolous insects, critical weight (CW) attainment triggers pupation and metamorphosis, but its mechanism remains unclear in non-model organisms like mosquitoes. Here, we investigate the role of 20-hydroxyecdysone (20E) in CW asses…

Investigating the effect of non-invasive trigeminal nerve stimulation on memory consolidation: Insights from animal and human studies Open

Liyi Chen, Qiang Sun, Nina Seminck, Hao Huang, Boateng Asamoah , et al. · 2025

MiR-92a-3p Promotes Renal Injury and Fibrosis Through Facilitating M1 Macrophage Polarization via Targeting LIN28A Open

Ming Xu, Xiangjun Zeng, Min‐Hsiung Pan, Robert Chen, Yun Bai , et al. · 2024

Infiltrated and activated M1 macrophages play a role in kidney injury and fibrosis during chronic kidney disease (CKD) progression. However, the specific ways that M1 macrophage polarization contributes to renal fibrosis are not fully unde…

Author Correction: An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption Open

Feng Zhang, Bo Zhang, Yuying Wang, Runmin Jiang, Jin Liu , et al. · 2024

Comprehensive analysis of cuproptosis-related genes involved in immune infiltration and their use in the diagnosis of hepatic ischemia-reperfusion injury: an experimental study Open

Xiaopeng Cai, Jingwen Deng, Xiaohu Zhou, Kaiyue Wang, Huiqiang Cai , et al. · 2024

Background: Hepatic ischemia-reperfusion injury (HIRI) is a common injury not only during liver transplantation but also during major hepatic surgery. HIRI causes severe complications and affects the prognosis and survival of patients. Cup…

Identification and Validation of JAM-A as a Novel Prognostic and Immune Factor in Human Tumors Open

Tianyi Ren, Zheng You, Feichang Liu, Chen-Yu Liu, Bo Zhang , et al. · 2024

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R), is a transmembrane glycoprotein that is involved in various biological processes, including cancer initiation and progression. However, the functional characteristi…

The discovery of hemoglobin body: a start to more Open

Bo Zhang, Yalan Yang, Yichao Zhu, Shi‐Nan Zhang, Hongyan Huang , et al. · 2024

Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression Open

Xiaoyan Gao, He Ren, Zhengrong Zhang, Cao Shuai, Bo Zhang , et al. · 2024

Challenges of Robust RNAi-Mediated Gene Silencing in Aedes Mosquitoes Open

Lucas Henrique Figueiredo Prates, Jakob Fiebig, Henrik Schlosser, Eleni Liapi, Tanja Rehling , et al. · 2024

In this study, we report the complexities and challenges associated with achieving robust RNA interference (RNAi)-mediated gene knockdown in the mosquitoes Aedes aegypti and Aedes albopictus, a pivotal approach for genetic analysis and vec…

How medical insurance payment systems affect the physicians’ provision behavior in China—based on experimental economics Open

Shuyan Lin, Qiang Sun, Hezeng Zhou, Jia Yin, Chao Zheng · 2024

Background It introduced an artefactual field experiment to analyze the influence of incentives from fee-for-service (FFS) and diagnosis-intervention package (DIP) payments on physicians’ provision of medical services. Methods This study r…

Wolbachia infection-responsive immune genes suppress Plasmodium falciparum infection in Anopheles stephensi Open

Vandana Kumari, Shengzhang Dong, Tanaya Sheth, Qiang Sun, Wen Han , et al. · 2024

Wolbachia , a maternally transmitted symbiotic bacterium of insects, can suppress a variety of human pathogens in mosquitoes, including malaria-causing Plasmodium in the Anopheles vector. However, the mechanistic basis of Wolbachia -mediat…

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis Open

Huating Wang, Yang Li, Chuhan Li, Qiang Sun, Fengyuan Chen , et al. · 2024

Stem cell activity is known to be tightly regulated by both intrinsic and extrinsic pathways but less is known about whether and how stem cells modulate their niche microenvironment. Adult skeletal muscle stem cells (MuSCs) are indispensab…

Pervasive RNA Binding Protein Enrichment on TAD Boundaries Regulates TAD Organization Open

Huating Wang, Qiang Sun, Qin Zhou, Yulong Qiao, Hao Sun · 2024

Mammalian genome is hierarchically organized by CTCF and cohesin through loop extrusion mechanism to facilitate the organization of topologically associating domains (TADs). Mounting evidence suggests additional factors/mechanisms exist to…

Skeletal Muscle Stem Cells Modulate Niche Function in Duchenne Muscular Dystrophy through YY1-CCL5 Axis Open

Yang Li, Chuhan Li, Qiang Sun, Fengyuan Chen, Yeelo Cheung , et al. · 2024

Stem cell activity is known to be tightly regulated by both intrinsic and extrinsic pathways but less is known about whether and how stem cells modulate their niche microenvironment. Adult skeletal muscle stem cells (MuSCs) are indispensab…

Anti-Aging Drugs and the Related Signal Pathways Open

Nannan Du, Yang Ruigang, Shengrong Jiang, Zubiao Niu, Wenzhao Zhou , et al. · 2024

Aging is a multifactorial biological process involving chronic diseases that manifest from the molecular level to the systemic level. From its inception to 31 May 2022, this study searched the PubMed, Web of Science, EBSCO, and Cochrane li…

Antioxidant capacity of sesamol in Caenorhabditis elegans model system Open

Jinian Huang, Shuning Qi, Qiang Sun, Guohui Song, Jixing Tang , et al. · 2024

Senescence is a general and irreversible process which depends on both inherent (free radical and age) and external (Ultraviolet irradiation) factors. Antioxidants and other natural compounds like plant and plant products are widespread us…

Elucidation of the evolutionary history of Stipa in China using comparative transcriptomic analysis Open

Na Sha, Zhiyong Li, Qiang Sun, Ying Han, Li Tian , et al. · 2023

Phylogenetic analysis provides crucial insights into the evolutionary relationships and diversification patterns within specific taxonomic groups. In this study, we aimed to identify the phylogenetic relationships and explore the evolution…

Macrophage polarization and metabolism in atherosclerosis Open

Pengbo Hou, Jiankai Fang, Zhanhong Liu, Yufang Shi, Massimiliano Agostini , et al. · 2023

p63: a crucial player in epithelial stemness regulation Open

Yanan Li, Sara Giovannini, Tingting Wang, Jiankai Fang, Peishan Li , et al. · 2023

Localising two sub-diffraction emitters in 3D using quantum correlation microscopy Open

Shuo Li, Wenchao Li, Qiang Sun, Bill Moran, Timothy C. Brown , et al. · 2023

The localisation of fluorophores is an important aspect of the determination of the biological function of cellular systems. Quantum correlation microscopy (QCM) is a promising technique for providing diffraction unlimited emitter localisa…

An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption Open

Feng Zhang, Bo Zhang, Yuying Wang, Runmin Jiang, Jin Liu , et al. · 2023

Harnessing metabolism of hepatic macrophages to aid liver regeneration Open

Rui Liu, Manuel Scimeca, Qiang Sun, Gerry Melino, Alessandro Mauriello , et al. · 2023

Liver regeneration is a dynamic and regulated process that involves inflammation, granulation, and tissue remodeling. Hepatic macrophages, abundantly distributed in the liver, are essential components that actively participate in each step…

The role of mesenchymal stem cells derived exosomes as a novel nanobiotechnology target in the diagnosis and treatment of cancer Open

You Zhou, Yuqing Dong, Aixue Zhang, Jibin Wu, Qiang Sun · 2023

Mesenchymal stem cells (MSCs), one of the most common types of stem cells, are involved in the modulation of the tumor microenvironment (TME). With the advancement of nanotechnology, exosomes, especially exosomes secreted by MSCs, have bee…

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