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View article: Compact Optical Reservoir Computing via Luminescence Dynamics in Rare‐Earth Ions‐Doped Nanocrystals
Compact Optical Reservoir Computing via Luminescence Dynamics in Rare‐Earth Ions‐Doped Nanocrystals Open
Optical neuromorphic computing offers a promising route to high‐speed, energy‐efficient information processing. However, photonic neurons, as the critical components for enhancing computational expressivity, still face significant bottlene…
View article: Experimental Demonstration of High-Security and Low-CSPR Single-Sideband Transmission System Based on 3D Lorenz Chaotic Encryption
Experimental Demonstration of High-Security and Low-CSPR Single-Sideband Transmission System Based on 3D Lorenz Chaotic Encryption Open
Broadcast-style downlinks (e.g., PONs and satellites) expose physical waveforms despite transport-layer cryptography, motivating physical-layer encryption (PLE). Digital chaotic encryption is appealing for its noise-like spectra, sensitivi…
View article: Causal relationship between chronic hepatitis B infection and gastric ulcer: A Mendelian randomization study
Causal relationship between chronic hepatitis B infection and gastric ulcer: A Mendelian randomization study Open
Chronic hepatitis B (CHB) infection is a global health burden with various extrahepatic manifestations, but its causal relationship with gastric ulcer remains unclear. This study investigated the causal effect of CHB infection on gastric u…
View article: The association between the incident risk of Parkinson’s disease and depression in middle-aged and older adults, and the moderating role of lifestyle: evidence from the CHARLS
The association between the incident risk of Parkinson’s disease and depression in middle-aged and older adults, and the moderating role of lifestyle: evidence from the CHARLS Open
Background Parkinson’s disease (PD) and depression frequently coexist in middle-aged and older populations, potentially influencing each other. This study explores the relationship between depression and PD risk and investigates the associ…
View article: Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy Open
Abnormal proliferation and migration of endothelial cells are key contributors to tumor angiogenesis. Recent studies have shown that the crucial role of E3 ubiquitin ligase neuronal precursor cell expression developmentally downregulated 4…
View article: Causal associations between iron deficiency anemia and digestive system cancers: evidence from a bidirectional two-sample Mendelian randomization study
Causal associations between iron deficiency anemia and digestive system cancers: evidence from a bidirectional two-sample Mendelian randomization study Open
The present MR analysis shows no causal associations between IDA and the risk of DSCs.
View article: Correlation of renal function with intra-patient variability of tacrolimus concentration among recipients of renal transplants: a 10-year study
Correlation of renal function with intra-patient variability of tacrolimus concentration among recipients of renal transplants: a 10-year study Open
Recipients of renal transplants with lower IPV in tacrolimus concentration appeared to have better renal function over time. Controlling IPV may contribute to improved renal outcomes post-transplantation.
View article: Outcomes of patients with infective endocarditis–associated acute kidney injury: a retrospective cohort study
Outcomes of patients with infective endocarditis–associated acute kidney injury: a retrospective cohort study Open
Background The outcomes of patients with infective endocarditis (IE)-associated acute kidney injury (AKI) are poorly understood. Methods This retrospective cohort study was conducted in a tertiary hospital in China to analyze the short- an…
View article: Exploring and comparing renal adverse effects between PARP inhibitors based on a real-world analysis of post-marketing surveillance data
Exploring and comparing renal adverse effects between PARP inhibitors based on a real-world analysis of post-marketing surveillance data Open
Objective Poly (ADP-ribose) polymerase inhibitors (PARPis) are emerging targeted therapeutic agents in oncology, primarily indicated for ovarian and metastatic breast cancer. Acute kidney injury (AKI) has been observed in patients undergoi…
View article: Case report: Nephrotic syndrome and portal hypertensive ascites after allogeneic hematopoietic stem cell transplantation: a rare manifestation of chronic graft-versus-host disease
Case report: Nephrotic syndrome and portal hypertensive ascites after allogeneic hematopoietic stem cell transplantation: a rare manifestation of chronic graft-versus-host disease Open
Chronic graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation (HSCT). Chronic GVHD may have atypical manifestations affecting non-classical organs. The diagnosis in patients with …
View article: Effects of hemodialysis adequacy on chronic kidney disease complications using latent class trajectory modeling: a real-world study based on long-term observation of Kt/V
Effects of hemodialysis adequacy on chronic kidney disease complications using latent class trajectory modeling: a real-world study based on long-term observation of Kt/V Open
Introduction Previous studies on hemodialysis adequacy primarily focused on the association between Kt/V and survival, and low Kt/V is associated with increased mortality. There is a paucity of research on the correlation between Kt/V and …
View article: Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy
Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy Open
Lipoprotein glomerulopathy (LPG) is a rare disorder characterized by the development of glomerular lipoprotein thrombosis. LPG exhibits familial aggregation, with mutations in the apolipoprotein E (APOE) gene identified as the leading caus…
View article: Genetic landscape and prognostic value of IRF4 alterations in Diffuse large B-cell lymphoma patients
Genetic landscape and prognostic value of IRF4 alterations in Diffuse large B-cell lymphoma patients Open
Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell NHL with high heterogeneity. Patients with IRF4 alterations in various hematologic malignancies have a different prognosis. Methods: From January 1 st , 2006 to Dec…
View article: Long-term outcomes with HLX01 (HanliKang®), a rituximab biosimilar, in previously untreated patients with diffuse large B-cell lymphoma: 5-year follow-up results of the phase 3 HLX01-NHL03 study
Long-term outcomes with HLX01 (HanliKang®), a rituximab biosimilar, in previously untreated patients with diffuse large B-cell lymphoma: 5-year follow-up results of the phase 3 HLX01-NHL03 study Open
HLX01 (HanliKang ® ) is a rituximab biosimilar that showed bioequivalence to reference rituximab in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) in the phase 3 HLX01-NHL03 study. Here, we report the 5-year follow-up result…
View article: Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer
Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer Open
Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader. It encodes proteins that contain several KH domains, which are important in RNA binding, RNA synthesis and metabolism. Lots of researches have studied …
View article: China Anti-Cancer Association (CACA) guidelines for holistic integrative management of lymphoma (version 2022)
China Anti-Cancer Association (CACA) guidelines for holistic integrative management of lymphoma (version 2022) Open
Purpose Lymphoma has become a major threat to human health. Fortunately, the diagnosis and treatment of lymphoma have developed rapidly, and research progress has emerged in an endless stream, with new drugs emerging one after another. The…
View article: Urinary proteomic analysis for biomarker discovery of pulmonary arterial hypertension-induced right ventricular failure
Urinary proteomic analysis for biomarker discovery of pulmonary arterial hypertension-induced right ventricular failure Open
Background Right ventricular failure (RVF) is one of the independent and strong predictors of mortality in pulmonary arterial hypertension (PAH). Urine is more suitable and sensitive for biomarker discovery with no need for homeostatic con…
View article: Efficacy and safety of PD‐1 monoclonal antibody plus rituximab in relapsed/refractory diffuse large B cell lymphoma patients
Efficacy and safety of PD‐1 monoclonal antibody plus rituximab in relapsed/refractory diffuse large B cell lymphoma patients Open
Background Patients with relapsed/refractory diffuse large B‐cell lymphoma (r/r DLBCL) have poor outcomes and few treatment options. We report the preliminary results of the efficacy and safety of PD‐1 monoclonal antibody (mab) plus Rituxi…
View article: #3424 RENAL OUTCOMES IN THE ELDERLY WITH ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED VASCULITIS: A NEW PREDICTION MODEL
#3424 RENAL OUTCOMES IN THE ELDERLY WITH ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODY-ASSOCIATED VASCULITIS: A NEW PREDICTION MODEL Open
Background and Aims Antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is a type of necrotizing small vessel inflammatory disease, including alveolar hemorrhage and rapidly progressive glomerulonephritis. Elderly patients …
View article: #3412 THE THROMBOTIC EVENTS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE COHORT STUDY AND MENDELIAN RANDOMIZATION ANALYSIS
#3412 THE THROMBOTIC EVENTS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE COHORT STUDY AND MENDELIAN RANDOMIZATION ANALYSIS Open
Background and Aims Thrombotic event in ANCA-associated vasculitis (AAV) was prevalent but not clarified in the causal relationship between AAV and thrombotic events. We tried to identify the clinical characteristics and risk factors of th…
View article: #3767 THE IMPACT OF COVID-19 PANDEMICS ON THE OUTCOME OF 24 CHINESE PATIENTS DIAGNOSED OF MEMBRANOUS NEPHROPATHY RECEIVING RITUXIMAB THERAPY
#3767 THE IMPACT OF COVID-19 PANDEMICS ON THE OUTCOME OF 24 CHINESE PATIENTS DIAGNOSED OF MEMBRANOUS NEPHROPATHY RECEIVING RITUXIMAB THERAPY Open
Background and Aims Rituximab has been considered as the first-line immunosuppressive therapy in membranous nephropathy. Anti-CD20 depleting therapy is associated with prolonged B-cell depletion and has been reported to increase risk of se…
View article: #3420 CLINICAL CHARACTERISTICS AND PRIMARY OUTCOMES OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIS AND CENTRAL DIABETES INSIPIDUS
#3420 CLINICAL CHARACTERISTICS AND PRIMARY OUTCOMES OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIS AND CENTRAL DIABETES INSIPIDUS Open
Background and Aims Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by systemic small-vessel vasculitis and may rarely present as central diabetes insipidus (CDI). AAV-associated CDI should be recog…
View article: Data from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Data from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer Open
Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasi…
View article: Supplementary Figure 2 from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Supplementary Figure 2 from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer Open
PDF file - 1414K, Supplemental Figure 2. CD90, CD44 and p75NTR / CD271 expression in matched non-tumor (N) and primary ESCC (T) (n = 33) as detected by real-time qPCR.
View article: Supplementary Figure Legend and Table 1 - 5 from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Supplementary Figure Legend and Table 1 - 5 from A CD90<sup>+</sup> Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer Open
DOC file - 322K, Supplemental Table 1. Primer sequences for real-time qPCR analyses. Supplemental Table 2. RPKM values of other reported CSC markers in the original 3 pairs of non-tumor (N) and ESCC (T) clinical samples (Patients #16, #18 …