Huiqin Li
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View article: Expert consensus on the clinical management of HIV late presentation
Expert consensus on the clinical management of HIV late presentation Open
With the advancement of combination antiretroviral therapy (cART), the global number of new human immunodeficiency virus (HIV) infections and HIV-related mortality has significantly declined. However, the high proportion of “late presentat…
View article: Preferences of patients with depression for medication management: a discrete choice experiment
Preferences of patients with depression for medication management: a discrete choice experiment Open
Background Depression threatens people’s health and imposes heavy economic burden on society. Oral antidepressants are the first-line treatment for depression. However, poor adherence in depressed patients contributes to poor clinical outc…
View article: Association of <i>ZNF608</i> Polymorphisms With House Dust Mite‐Induced Allergic Rhinitis
Association of <i>ZNF608</i> Polymorphisms With House Dust Mite‐Induced Allergic Rhinitis Open
Background Genetic factors contribute essentially to the pathophysiology of house dust mite (HDM)‐induced allergic rhinitis. Previous studies mainly focused on the biological pathogenesis, but the heritability remains poorly explained. Met…
View article: The Dual Roles of Autophagy in Pituitary Adenomas: Current Research Status
The Dual Roles of Autophagy in Pituitary Adenomas: Current Research Status Open
Pituitary adenomas (PAs) are tumors originating from the anterior lobe of the pituitary gland. Although most are benign, some may exhibit invasive behavior. While surgical treatment is effective in controlling most PAs, it carries inherent…
View article: The Ultrastructure of Olfactory Sensilla Across the Antenna of Monolepta signata (Oliver)
The Ultrastructure of Olfactory Sensilla Across the Antenna of Monolepta signata (Oliver) Open
The antennal sensilla serve as a crucial olfactory organ, enabling insects to detect semiochemicals and adjust their host-seeking and oviposition behaviors accordingly. Monolepta signata (Oliver) (Coleoptera: Chrysomelidae), has emerged as…
View article: The Ultrastructure of Olfactory Sensilla Across Antenna of <i>Monolepta signata</i> (Oliver)
The Ultrastructure of Olfactory Sensilla Across Antenna of <i>Monolepta signata</i> (Oliver) Open
The antenna sensilla serves as a crucial olfactory organ, enabling insects to detect semiochemicals and adjust their host-seeking and oviposition behaviors accordingly. Monolepta signata (Oliver) (Coleoptera: Chrysomelidae), has emerged as…
View article: Enablers and Barriers to Medication Self-Management in Patients With Type 2 Diabetes: A Qualitative Study Using the COM-B Model
Enablers and Barriers to Medication Self-Management in Patients With Type 2 Diabetes: A Qualitative Study Using the COM-B Model Open
This study proposes targeted medication self-management programs, including education interventions to improve medication literacy and self-efficacy, leveraging mobile smart devices, and improving health insurance policies to promote patie…
View article: The U-shaped Curve of Energy Supply in the First 72 Hours of Critical Illness May Apply Only to Patients with Normal Body Mass Index: A Post-hoc Analysis of a Prospective Observational Multicenter Study
The U-shaped Curve of Energy Supply in the First 72 Hours of Critical Illness May Apply Only to Patients with Normal Body Mass Index: A Post-hoc Analysis of a Prospective Observational Multicenter Study Open
Objective Nutritional support is crucial for critically ill patients. Body mass index (BMI) represents nutritional reserves to some extent, but it is unclear whether the U-shaped relationship between caloric delivery during the acute phase…
View article: Intermittent Use of Flash Glucose Monitoring Improves Glycemic Control in Chinese Older Patients with Type 2 Diabetes Mellitus
Intermittent Use of Flash Glucose Monitoring Improves Glycemic Control in Chinese Older Patients with Type 2 Diabetes Mellitus Open
Intermittent use of FGM is associated with an improvement in glycemic outcomes and reduces the risk of hypoglycemia in Chinese elderly patients with T2DM.
View article: Identification of Rare Genetic Variants in Childhood Acute Lymphoblastic Leukemia and Their Association with Laboratory Tests after Long-Term Survival
Identification of Rare Genetic Variants in Childhood Acute Lymphoblastic Leukemia and Their Association with Laboratory Tests after Long-Term Survival Open
Background: Acute lymphoblastic leukemia (ALL), the most prevalent malignant carcinoma in children, is closely associated with genetic alterations. Susceptible loci derived from conventional association analyses are primarily common varian…
View article: Corrigendum: Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes
Corrigendum: Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes Open
[This corrects the article DOI: 10.3389/fendo.2024.1374496.].
View article: Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes
Accuracy of a novel real-time continuous glucose monitoring system: a prospective self-controlled study in thirty hospitalized patients with type 2 diabetes Open
Aims The present study aimed to investigate the accuracy of the Glunovo ® real-time continuous glucose monitoring system (rtCGMS). Methods We conducted a 14-day interstitial glucose level monitoring using Glunovo ® rtCGMS on thirty hospita…
View article: An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study
An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study Open
Background Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosi…
View article: Effects of a Novel Glucokinase Activator, Dorzagliatin, on Glycemic Control and Glucose Fluctuation in Drug-Naïve Patients with Type 2 Diabetes Mellitus
Effects of a Novel Glucokinase Activator, Dorzagliatin, on Glycemic Control and Glucose Fluctuation in Drug-Naïve Patients with Type 2 Diabetes Mellitus Open
Aim. The prevalence rate of type 2 diabetes mellitus (T2DM) has been increasing and a large proportion of patients still do not achieve adequate or sustainable glycemic control on the basis of previous hypoglycemic treatment. In this prese…
View article: Effect of Chiglitazar and Sitagliptin on Bone Mineral Density and Body Composition in Untreated Patients with Type 2 Diabetes
Effect of Chiglitazar and Sitagliptin on Bone Mineral Density and Body Composition in Untreated Patients with Type 2 Diabetes Open
The trial is registered at ClinicalTrials.gov (CT.gov identifier: NCT02173457).
View article: Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants
Construction, evaluation, and AOP framework-based application of the EpPRS as a genetic surrogate for assessing environmental pollutants Open
EpPRSs can serve as a proxy for assessing pollutant internal exposure. The application of the EpPRS to disease risk assessment can reveal the toxic pathway and mode of action linking exposure and disease in detail, providing a basis for th…
View article: Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer
Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer Open
Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship in treatment-naive ani…
View article: A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo
A rationally designed fluorescence probe achieves highly specific and long‐term detection of senescence in vitro and in vivo Open
Senescent cells (SnCs) are implicated in aging and various age‐related pathologies. Targeting SnCs can treat age‐related diseases and extend health span. However, precisely tracking and visualizing of SnCs is still challenging, especially …
View article: Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS
Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS Open
The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis, but a comprehensive understanding of their association with and relevant biomarkers involved …
View article: Effect of polycyclic aromatic hydrocarbons on cancer risk causally mediated via vitamin D levels
Effect of polycyclic aromatic hydrocarbons on cancer risk causally mediated via vitamin D levels Open
Polycyclic aromatic hydrocarbons (PAHs) widely exist in environmental substrates and are closely related to individual circulating vitamin D levels and tumorigenesis. Therefore, we proposed to evaluate the relationship between PAH exposure…
View article: SUMMER: a Mendelian randomization interactive server to systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival
SUMMER: a Mendelian randomization interactive server to systematically evaluate the causal effects of risk factors and circulating biomarkers on pan-cancer survival Open
Genome-wide association studies (GWASs) underlying case-control design have uncovered hundreds of genetic loci involved in tumorigenesis and provided rich resources for identifying risk factors and biomarkers associated with cancer suscept…
View article: Increased Glycemic Variability Evaluated by Continuous Glucose Monitoring is Associated with Osteoporosis in Type 2 Diabetic Patients
Increased Glycemic Variability Evaluated by Continuous Glucose Monitoring is Associated with Osteoporosis in Type 2 Diabetic Patients Open
Background Subjects with type 2 diabetes mellitus (T2DM) are susceptible to osteoporosis. This study was conducted to evaluate the association between glycemic variability evaluated by continuous glucose monitoring (CGM) and osteoporosis i…
View article: Basal Insulin Reduces Glucose Variability and Hypoglycaemia Compared to Premixed Insulin in Type 2 Diabetes Patients: A Study Based on Continuous Glucose Monitoring Systems
Basal Insulin Reduces Glucose Variability and Hypoglycaemia Compared to Premixed Insulin in Type 2 Diabetes Patients: A Study Based on Continuous Glucose Monitoring Systems Open
Aims To examine the glycaemic variability and safety of basal and premixed insulin by using continuous glucose monitoring (CGM) systems. Methods 393 patients with type 2 diabetes mellitus (T2DM) treated with basal or premixed insulin for m…