Chuan Qin
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View article: A Co-Simulation Framework for Steady-State Analyses of Multiple Droop-based MTdc Grids in Continental-Scale Systems
A Co-Simulation Framework for Steady-State Analyses of Multiple Droop-based MTdc Grids in Continental-Scale Systems Open
View article: Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease
Hub genes and diagnostic model associated with mitochondrial function in Alzheimer's disease Open
Background Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder, with mitochondrial dysfunction being observed in both AD patients and mouse models. Nonetheless, further investigation is required to elucidate t…
View article: Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis
Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis Open
BACKGROUND Cholelithiasis is a prevalent biliary tract disorder primarily characterized by gallbladder or biliary stone formation. Although succinylation has been extensively studied as a protein post-translational modification, its role i…
View article: Preparation and Neuroprotective Effects of Bergamot Essential Oil Liposomes in a PC12 Cell Model of Alzheimer’s Disease
Preparation and Neuroprotective Effects of Bergamot Essential Oil Liposomes in a PC12 Cell Model of Alzheimer’s Disease Open
Bergamot essential oil (BEO) exhibits anxiolytic and antidepressant properties but its biomedical use is restricted by poor solubility, volatility, and instability. Liposomal encapsulation offers a strategy to enhance the stability and bio…
View article: An interpretable machine learning model for assessing the risk of Talaromycosis in HIV patients lacking skin lesions
An interpretable machine learning model for assessing the risk of Talaromycosis in HIV patients lacking skin lesions Open
Introduction: The existing predictive models for talaromycosis in HIV-infected patients without skin lesions are limited by established risk factors and traditional statistical approaches. This study aims to develop an interpretable machin…
View article: Associations of lactate-to-hematocrit ratio with short- and long-term prognoses in critically ill patients with cirrhosis and sepsis: a retrospective cohort study
Associations of lactate-to-hematocrit ratio with short- and long-term prognoses in critically ill patients with cirrhosis and sepsis: a retrospective cohort study Open
High LHR values were strongly associated with poor short- and long-term prognoses in critically ill patients with cirrhosis and sepsis.
View article: TransLLM: A Unified Multi-Task Foundation Framework for Urban Transportation via Learnable Prompting
TransLLM: A Unified Multi-Task Foundation Framework for Urban Transportation via Learnable Prompting Open
Urban transportation systems encounter diverse challenges across multiple tasks, such as traffic forecasting, electric vehicle (EV) charging demand prediction, and taxi dispatch. Existing approaches suffer from two key limitations: small-s…
View article: Establishment of a patient‐derived drug‐resistant oral squamous cell carcinoma animal model
Establishment of a patient‐derived drug‐resistant oral squamous cell carcinoma animal model Open
Oral squamous cell carcinoma (OSCC) constitutes 90% of oral tumors. Advanced cases severely impair patients' life quality of life due to anatomical location and limited therapies. Conventional treatments often induce drug resistance or rec…
View article: Optimizing farmland shelterbelts identification: a novel framework based on the PF-Deeplab model and multi-task collaborative strategy
Optimizing farmland shelterbelts identification: a novel framework based on the PF-Deeplab model and multi-task collaborative strategy Open
View article: Predictive role of the Albumin-Bilirubin score in ICU patients with cirrhosis and sepsis: insights from a large retrospective cohort
Predictive role of the Albumin-Bilirubin score in ICU patients with cirrhosis and sepsis: insights from a large retrospective cohort Open
View article: Multipotency of Adipose-Derived Stem Cells from Cynomolgus Monkeys
Multipotency of Adipose-Derived Stem Cells from Cynomolgus Monkeys Open
Background Adipose tissue is a rich source, and adipose-derived stem cells (ADSCs) are easy to isolate and expand and pose a low risk of tumorigenicity. ADSCs therefore represent a promising source for autologous transplantation, while avo…
View article: Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response
Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response Open
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by macroscopic features such as cortical atrophy, narrowing of the gyri, widening of the sulci, and enlargement of the ventricles. At the cellular level, the pathologic…
View article: Market competitiveness and corporate ESG performance
Market competitiveness and corporate ESG performance Open
View article: Tongue swab-based molecular diagnostics for pulmonary tuberculosis and drug resistance in adults: A prospective multicenter diagnostic accuracy study
Tongue swab-based molecular diagnostics for pulmonary tuberculosis and drug resistance in adults: A prospective multicenter diagnostic accuracy study Open
PCR-based tongue swab testing offers a rapid, non-invasive alternative for TB diagnosis with high accuracy, particularly in paucibacillary cases or individuals unable to provide sputum. Although all participants in this study were able to …
View article: Genome-Wide Identification of Ginkgo biloba SPL Gene Family and Expression Analysis in Flavonoid Biosynthesis and Water Stress
Genome-Wide Identification of Ginkgo biloba SPL Gene Family and Expression Analysis in Flavonoid Biosynthesis and Water Stress Open
SQUAMOSA promoter-binding protein-like (SPL) transcription factors specific to plants are vital for regulating growth, development, secondary metabolite biosynthesis, and responses to both biotic and abiotic stresses. Despite their importa…
View article: Relationship between coagulopathy score and survival in critically ill patients with liver cirrhosis and sepsis: a retrospective study
Relationship between coagulopathy score and survival in critically ill patients with liver cirrhosis and sepsis: a retrospective study Open
View article: Analysis of recycling and emission reduction models under carbon taxes and government subsidies
Analysis of recycling and emission reduction models under carbon taxes and government subsidies Open
This study constructs a recycling and emission reduction model where a third party is responsible for recycling, and the manufacturer is responsible for remanufacturing. We compare three scenarios: no government subsidy, government subsidi…
View article: Progress in research on osteoporosis secondary to <scp>SARS</scp>‐<scp>CoV</scp>‐2 infection
Progress in research on osteoporosis secondary to <span>SARS</span>‐<span>CoV</span>‐2 infection Open
The World Health Organization has declared that COVID‐19 no longer constitutes a “public health emergency of international concern,” yet the long‐term impact of SARS‐CoV‐2 infection on bone health continues to pose new challenges for globa…
View article: Lactate-to-albumin ratio as a potential prognostic predictor in patients with cirrhosis and sepsis: a retrospective cohort study
Lactate-to-albumin ratio as a potential prognostic predictor in patients with cirrhosis and sepsis: a retrospective cohort study Open
View article: Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the <scp>5xFAD</scp> transgenic mouse model
Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the <span>5xFAD</span> transgenic mouse model Open
Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of…
View article: Immunometabolism of Liver Xenotransplantation and Prospective Solutions
Immunometabolism of Liver Xenotransplantation and Prospective Solutions Open
End‐stage liver diseases, such as hepatocellular carcinoma or acute liver failure, critically necessitate liver transplantation. However, the shortage of available organ donors fails to meet the rapidly growing transplantation demand. Due …
View article: ILC3 Function as a Double-Edged Sword in EV71 Infection
ILC3 Function as a Double-Edged Sword in EV71 Infection Open
Enterovirus 71 (EV71) is a common pathogen responsible for hand, foot, and mouth disease (HFMD), leading to severe neurological complications and even death. However, the mechanisms underlying severe EV71-induced disease remain unclear, an…
View article: Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development
Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development Open
View article: Embarking on a new journey, exploring infinite possibilities—Welcoming the 2025 edition of <i>Animal Models and Experimental Medicine</i>
Embarking on a new journey, exploring infinite possibilities—Welcoming the 2025 edition of <i>Animal Models and Experimental Medicine</i> Open
View article: An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study
An Explainable Two-Stage Machine Learning Model for Predicting the Post-Thrombolysis Complications in Stroke Patients: A Multi-Center Study Open
Current tools for predicting the thrombolysis risk in patients after stroke exhibit limited event prediction in early post-thrombolysis hemorrhagic events. This highlights an unmet medical need to improve the tools for stroke management. W…
View article: Stability Domain Construction and Tuning for External Loop Controller Parameters Based on Permanent Magnet Wind Power Generation Systems
Stability Domain Construction and Tuning for External Loop Controller Parameters Based on Permanent Magnet Wind Power Generation Systems Open
Based on the closed‐loop frequency domain model of permanent magnet synchronous generator–based wind power generation system (PMSG‐WPGS), the stability domain of the control parameters is constructed through the D‐partition method in this …
View article: Long Term Safety and Efficacy of Oral Extended-Release Ketamine: Results from the Bedroc-1 Study
Long Term Safety and Efficacy of Oral Extended-Release Ketamine: Results from the Bedroc-1 Study Open
View article: Metagenomic analysis reveals the community composition of the microbiome in different segments of the digestive tract in donkeys and cows: implications for microbiome research
Metagenomic analysis reveals the community composition of the microbiome in different segments of the digestive tract in donkeys and cows: implications for microbiome research Open
The results obtained by both sampling methods in the present study revealed that the composition and function of the intestinal microbiota in donkeys and cows exhibit species-specific and region-specific differences. These findings highlig…
View article: Distribution and diversity of classical deacylases in bacteria
Distribution and diversity of classical deacylases in bacteria Open
View article: Interleukin-6 deficiency reduces neuroinflammation by inhibiting the STAT3-cGAS-STING pathway in Alzheimer’s disease mice
Interleukin-6 deficiency reduces neuroinflammation by inhibiting the STAT3-cGAS-STING pathway in Alzheimer’s disease mice Open