Qiang Ruan
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View article: GPX8 COL1A1 RAB31 and Other Genes as Diagnostic Biomarkers for Crohns Disease: A Bioinformatics Analysis Using Machine Learning
GPX8 COL1A1 RAB31 and Other Genes as Diagnostic Biomarkers for Crohns Disease: A Bioinformatics Analysis Using Machine Learning Open
Crohn's disease, Genes, Prediction model, Machine learning.
View article: Transcriptome Analysis of Natural Albino Northern Snakehead (Channa argus var.) Provides Novel Insights into Color-Related Genes
Transcriptome Analysis of Natural Albino Northern Snakehead (Channa argus var.) Provides Novel Insights into Color-Related Genes Open
The northern snakehead (Channa argus) is an important economic fish species that holds a significant position in Chinese aquaculture due to its high nutritional value, fast growth, and anti-hypoxia capacity. There is a natural albino-mutan…
View article: Yangweishu Ameliorates Chronic Atrophic Gastritis with Stomach Yin Deficiency Syndrome Through IL-6/STAT3 Signaling Pathway
Yangweishu Ameliorates Chronic Atrophic Gastritis with Stomach Yin Deficiency Syndrome Through IL-6/STAT3 Signaling Pathway Open
YWS has a good therapeutic effect on YDCAG, which may be closely related to the inhibition of IL-6/STAT3 signaling pathway.
View article: <i>RHOBTB2</i> Variant p.<scp>Arg511Gln</scp> Causes Developmental and Epileptic Encephalopathy Type 64 in an Infant: A Case Report and Hotspot Variant Analysis
<i>RHOBTB2</i> Variant p.<span>Arg511Gln</span> Causes Developmental and Epileptic Encephalopathy Type 64 in an Infant: A Case Report and Hotspot Variant Analysis Open
Background Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of brain disorders. Variants in the Rho‐related BTB domain‐containing 2 gene ( RHOBTB2 ) can lead to DEE64, which is characterized by early‐onset epil…
View article: The Influence of Extra-Ribosomal Functions of Eukaryotic Ribosomal Proteins on Viral Infection
The Influence of Extra-Ribosomal Functions of Eukaryotic Ribosomal Proteins on Viral Infection Open
The eukaryotic ribosome is a large ribonucleoprotein complex consisting of four types of ribosomal RNA (rRNA) and approximately 80 ribosomal proteins (RPs), forming the 40S and 60S subunits. In all living cells, its primary function is to …
View article: Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis Open
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the peripheral nervous system (PNS). However, the complete pathogenesis of neural differentiation …
View article: Integrated single-cell and bulk RNA sequencing in pancreatic cancer identifies disulfidptosis-associated molecular subtypes and prognostic signature
Integrated single-cell and bulk RNA sequencing in pancreatic cancer identifies disulfidptosis-associated molecular subtypes and prognostic signature Open
Pancreatic cancer (PC) is known for its high degree of heterogeneity and exceptionally adverse outcome. While disulfidptosis is the most recently identified form of cell death, the predictive and therapeutic value of disulfidptosis-related…
View article: Identification and characterization of human cytomegalovirus-encoded circular RNAs
Identification and characterization of human cytomegalovirus-encoded circular RNAs Open
Circular RNA (circRNA) exists extensively and plays essential roles in serving as microRNA (miRNA) or protein sponges and protein scaffolding in many organisms. However, the profiles and potential functions of the virus-encoded circRNA, in…
View article: Inhibition of Human Cytomegalovirus Particle Maturation by Activation of Liver X Receptor
Inhibition of Human Cytomegalovirus Particle Maturation by Activation of Liver X Receptor Open
Human cytomegalovirus (HCMV), a herpesvirus family member, is a large, complex enveloped virus. The activation of liver X receptor (LXR) can significantly inhibit the replication of HCMV and weaken the virulence of progeny virus (unpublish…
View article: Human cytomegalovirus RNA2.7 inhibits RNA polymerase II (Pol II) Serine-2 phosphorylation by reducing the interaction between Pol II and phosphorylated cyclin-dependent kinase 9 (pCDK9)
Human cytomegalovirus RNA2.7 inhibits RNA polymerase II (Pol II) Serine-2 phosphorylation by reducing the interaction between Pol II and phosphorylated cyclin-dependent kinase 9 (pCDK9) Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen belongs to betaherpesvirus subfamily. RNA2.7 is a highly conserved long non-coding RNA accounting for more than 20% of total viral transcripts. In our study, functions of HCMV RNA2.7 we…
View article: Correction to: Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection
Correction to: Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection Open
View article: Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection
Human Cytomegalovirus Influences Host circRNA Transcriptions during Productive Infection Open
View article: Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells
Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells Open
View article: Identification and characterization of a novel group of natural anti-sense transcripts from RNA1.2 gene locus of human cytomegalovirus
Identification and characterization of a novel group of natural anti-sense transcripts from RNA1.2 gene locus of human cytomegalovirus Open
A cluster of novel NATs was transcribed from the opposite sequence of the HCMV RNA1.2 gene region.
View article: Human cytomegalovirus RNA2.7 regulates host cell cycle and facilitates viral DNA replication by inhibiting RNA polymerase II phosphorylation
Human cytomegalovirus RNA2.7 regulates host cell cycle and facilitates viral DNA replication by inhibiting RNA polymerase II phosphorylation Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen belongs to the beta herpesvirus family. RNA2.7 is a viral long non-coding RNA accounting for more than 20% of total viral transcripts at early time of infection. By construction of RNA2…
View article: Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA
Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA Open
View article: Transcriptional regulation and influence on replication of the human cytomegalovirus UL138 1.4 kb transcript
Transcriptional regulation and influence on replication of the human cytomegalovirus UL138 1.4 kb transcript Open
Human cytomegalovirus (HCMV) exists in a latent form in hematopoietic progenitors and undifferentiated cells of myeloid lineage. Protein UL138, encoded by the UL/b' region of the viral genome, serves an important role in the establishment …
View article: Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells
Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells Open
The human cytomegalovirus (HCMV) encodes ≥26 microRNAs (miRNAs). These miRNAs are utilized by HCMV to regulate its own genes in addition to the genes of the host cell, during infection. The present study first identified p21‑activated kina…
View article: Increased methylation of human papillomavirus type 16 DNA is associated with the severity of cervical lesions in infected females from northeast China
Increased methylation of human papillomavirus type 16 DNA is associated with the severity of cervical lesions in infected females from northeast China Open
Hypermethylation of the cytosine-phosphate-guanine (CpG) sites located at the 3'-major capsid protein L1 (3'L1) and the long control region (LCR) of the human papillomavirus (HPV) genome may be associated with the progression of cervical c…
View article: Viral load and integration status of HPV58 associated with cervical lesion severity in women of Northeast China
Viral load and integration status of HPV58 associated with cervical lesion severity in women of Northeast China Open
The HPV58 viral load in patients with precancerous cervical lesions or cervical cancer increases significantly with disease progression. The HPV58 E2/E6 copy number ratio in patients with cervical cancer is lower than that for less severe …
View article: Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication
Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication Open
The interaction between the host and human cytomegalovirus (HCMV) is important in determining the outcome of a viral infection. The HCMV RL13 gene product exerts independent, inhibitory effects on viral growth in fibroblasts and epithelial…
View article: Development of a fluorescence–based multiplex genotyping method for simultaneous determination of human papillomavirus infections and viral loads
Development of a fluorescence–based multiplex genotyping method for simultaneous determination of human papillomavirus infections and viral loads Open
View article: Newly identified transcripts of UL4 and UL5 genes of human cytomegalovirus
Newly identified transcripts of UL4 and UL5 genes of human cytomegalovirus Open
Human cytomegalovirus (HCMV) UL4 and UL5 genes are two members of the RL11 gene family. In an earlier study, three UL4 transcripts of about 1.7, 1.5 and 1.4 kb were found in early and late classes after infection by the Towne strain by nuc…