Anna H. Wu
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View article: Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development
Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development Open
Recent research suggests higher circulating lymphocyte counts may protect against colorectal cancer (CRC). However, the role of specific lymphocyte subtypes and activation states remain unclear. CD4+ T cells—a highly dynamic lymphocyte sub…
View article: Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction
Pathway polygenic risk scores (pPRS) for the analysis of gene-environment interaction Open
A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk …
View article: Case Study for Developing a UXR Point of View for FinOps Product Innovation
Case Study for Developing a UXR Point of View for FinOps Product Innovation Open
In the dynamic landscape of Cloud financial management, we are sharing a case study exploring the development of a User Experience Research (UXR) Point of View (PoV) to drive FinOps product innovation. We demonstrate how qualitative and qu…
View article: Data from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study
Data from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study Open
Background:Consistent evidence supports a reduction in breast cancer risk with a high healthy lifestyle index (HLI) score; however, this relationship has not been well studied in multiethnic populations.Methods:Within the multiethnic cohor…
View article: Supplemental Table 4 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study
Supplemental Table 4 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study Open
Supplemental Table 4 shows adjusted hazard ratios and 95% confidence intervals for the association between the HLI (operationalized using EPIC scoring) and invasive breast cancer risk among postmenopausal women overall and by race and ethn…
View article: Supplemental Table 2 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study
Supplemental Table 2 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study Open
Supplemental Table 2 shows adjusted hazard ratios and 95% confidence intervals for the association between the five-component Healthy Lifestyle Index and hormone-receptor-positive and negative invasive breast cancer risk among postmenopaus…
View article: Supplemental Table 1 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study
Supplemental Table 1 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study Open
Supplemental Table 1 shows adjusted hazard ratios and 95% confidence intervals for the association between the Healthy Lifestyle Index without sleep and sedentary behavior components and breast cancer risk among postmenopausal women overal…
View article: Supplemental Table 3 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study
Supplemental Table 3 from Healthy Lifestyle Index and Breast Cancer Risk among Postmenopausal Women: The Multiethnic Cohort Study Open
Supplemental Table 3 shows the adjusted hazard ratios and 95% confidence intervals for the association between individual HLI components and risk of invasive breast cancer overall and by race and ethnicity among postmenopausal women in MEC
View article: Table S3 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Table S3 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
This table shows the associations between epidemiologic risk factors and HGSC subtypes, restricted to White cases and controls
View article: Figure S1 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Figure S1 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
Distribution of subtype proportions by subtype assignment
View article: Table S2 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Table S2 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
This table shows the associations between epidemiologic factors and HGSC subtypes restricted to HGSC cases with probability of subtype assignment >80%.
View article: Data from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Data from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
Background:Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology o…
View article: Table S1 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Table S1 from Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
This table shows the availability of epidemiologic factors used in the analyses across the different studies.
View article: Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development
Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development Open
Background Recent research has identified a potential protective effect of higher numbers of circulating lymphocytes on colorectal cancer (CRC) development. However, the importance of different lymphocyte subtypes and activation states in …
View article: Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes
Patterns of Associations with Epidemiologic Factors by High-Grade Serous Ovarian Cancer Gene Expression Subtypes Open
Background: Ovarian high-grade serous carcinomas (HGSC) comprise four distinct molecular subtypes based on mRNA expression patterns, with differential survival. Understanding risk factor associations is important to elucidate the etiology …
View article: Diet and survival after a diagnosis of ovarian cancer: a pooled analysis from the Ovarian Cancer Association Consortium
Diet and survival after a diagnosis of ovarian cancer: a pooled analysis from the Ovarian Cancer Association Consortium Open
Adherence to a more healthy, less-inflammatory diet may confer a survival benefit for individuals with early-stage ovarian cancer.
View article: Identifying adipocyte-derived exosomal miRNAs as potential novel prognostic markers for radiotherapy of esophageal squamous cell carcinoma
Identifying adipocyte-derived exosomal miRNAs as potential novel prognostic markers for radiotherapy of esophageal squamous cell carcinoma Open
BACKGROUND Radiation resistance limits radiotherapy efficacy in esophageal squamous cell carcinoma (ESCC). The tumor microenvironment, particularly adipocytes, plays a role in promoting cancer progression. Extracellular vesicles and microR…
View article: Analyzing Global Inequality Reflected in National Policies During the COVID-19 Pandemic
Analyzing Global Inequality Reflected in National Policies During the COVID-19 Pandemic Open
With the growth of the global economy and population, global inequality is becoming increasingly prominent. This inequality is not only reflected in income, education, healthcare, etc., but also affects economic development and social stab…
View article: Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction
Pathway Polygenic Risk Scores (pPRS) for the Analysis of Gene-environment Interaction Open
A polygenic risk score (PRS) is used to quantify the combined disease risk of many genetic variants. For complex human traits there is interest in determining whether the PRS modifies, i.e. interacts with, important environmental (E) risk …
View article: Risk factors for second primary breast cancer by laterality, age, and race and ethnicity
Risk factors for second primary breast cancer by laterality, age, and race and ethnicity Open
Background Epidemiological studies of risk factors for second primary breast cancer (SBC) have been conducted primarily in non-Hispanic White (NHW) women. Methods A racially and ethnically diverse population-based pooled cohort of 9639 wom…
View article: Lead Acetate Exposure and Cerebral Amyloid Accumulation: Mechanistic Evaluations in APP/PS1 Mice
Lead Acetate Exposure and Cerebral Amyloid Accumulation: Mechanistic Evaluations in APP/PS1 Mice Open
Our findings suggest that PbAc induced CAA/AD pathogenesis via the PAI-1 signaling in the APP/PS1 mouse model, and the inhibition of PAI-1 could be a potential therapeutic target for PbAc-mediated CAA/AD disorders. https://doi.org/10.1289/…
View article: Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer
Genetic Variation and Regulation of MICA Alters Natural Killer Cell-Mediated Immunosurveillance in Early-Onset Colorectal Cancer Open
The incidence of colorectal cancer (CRC) among individuals under age 50, or early-onset CRC (EOCRC), has been rising over the past few decades for unclear reasons, and the etiology of the disease remains largely unknown. Known genetic risk…
View article: Supplementary Figure 1 from Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium
Supplementary Figure 1 from Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium Open
Supplementary Figure 1 shows a flowchart of exclusions to obtain the study population, with the number of cases and controls eligible for the analysis.
View article: Supplementary Table 4 from Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium
Supplementary Table 4 from Folate intake and ovarian cancer risk among women with endometriosis: a case-control study from the Ovarian Cancer Association Consortium Open
Supplementary Table 4 shows the association between glycemic index, glycemic load, grain intake and risk of ovarian cancer for women with and without endometriosis.