Canqing Yu
YOU?
Author Swipe
View article: Associations of diabetes status, duration, and onset age with the risk of lung cancer: Results from the China Kadoorie Biobank study
Associations of diabetes status, duration, and onset age with the risk of lung cancer: Results from the China Kadoorie Biobank study Open
This study examined the associations of diabetes status, duration, and age at onset with lung cancer risk in the China Kadoorie Biobank. We prospectively assessed the association between diabetes status and lung cancer risk in 510,148 canc…
View article: Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations Open
Aging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank ( n = 43,616) and validated t…
View article: The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study
The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study Open
Background Gaps concerning general adiposity and chronic obstructive pulmonary disease (COPD) are delaying policies for weight interventions in COPD prevention, especially adiposity in early adulthood and weight changes during adulthood. M…
View article: Physical and Psychological Predictors for Persistent and Recurrent Non‐Specific Neck Pain: A Systematic Review
Physical and Psychological Predictors for Persistent and Recurrent Non‐Specific Neck Pain: A Systematic Review Open
Background Patients with non‐specific neck pain often develop persistent or recurrent pain and associated disability. This review investigated which physical and psychological factors predict persistent and recurrent neck pain and disabili…
View article: Epidemiological characteristics of hand, foot and mouth disease in Pingdu, Shandong, China from 2013 to 2023 and DLNM analysis of its variation with temperature
Epidemiological characteristics of hand, foot and mouth disease in Pingdu, Shandong, China from 2013 to 2023 and DLNM analysis of its variation with temperature Open
Background The purpose of this study is to describe the epidemiological situation of HFMD in Pingdu over the past decade, and investigate the relationship between environmental factors, specifically temperature, and the incidence of hand, …
View article: Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank
Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank Open
Background Pathogens have been one of the primary sources of natural selection affecting modern humans. The footprints of historical selection events – “selective sweeps”– can be detected in the genomes of present-day individuals. Previous…
View article: Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment
Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment Open
Sonodynamic therapy (SDT) is an emerging modality for cancer treatment that induces immunogenic cell death (ICD) through reactive oxygen species (ROS) generation, thereby triggering potent antitumor immunity. However, the hypoxic and gluta…
View article: A phenome-wide spectrum of morbidity and mortality risks related to the number of offspring among 0.5 million Chinese men and women: A prospective cohort study
A phenome-wide spectrum of morbidity and mortality risks related to the number of offspring among 0.5 million Chinese men and women: A prospective cohort study Open
Background: Prospective evidence on how offspring number influences morbidity and mortality remains limited. This study investigated the associations between number of offspring and morbidity and mortality risks among 0.5 million Chinese a…
View article: Successful management with hemoperfusion and antidotal therapy of severe combined dichlorvos and rodenticide poisoning: a case report
Successful management with hemoperfusion and antidotal therapy of severe combined dichlorvos and rodenticide poisoning: a case report Open
Background This case report presents a rare instance of combined dichlorvos (organophosphate) and brodifacoum (rodenticide) poisoning. By analyzing the clinical presentation and therapeutic course, we aim to provide insights into the chall…
View article: Unveiling the mechanisms of yanhusuo’s therapeutic effects in neuropathic pain through network pharmacology, single-cell RNA sequencing, and molecular docking
Unveiling the mechanisms of yanhusuo’s therapeutic effects in neuropathic pain through network pharmacology, single-cell RNA sequencing, and molecular docking Open
Background Current therapeutic strategies for neuropathic pain (NP) encompass pharmacological agents, physical modalities, psychological support, and interventional procedures, which aim to mitigate inflammation, enhance vascular perfusion…
View article: Association of Anaemia and Anthropometric Indices Among Chinese Adults: Based on the Sixth China Chronic Disease and Risk Factor Surveillance
Association of Anaemia and Anthropometric Indices Among Chinese Adults: Based on the Sixth China Chronic Disease and Risk Factor Surveillance Open
Background: Anaemia remains a widespread global public health concern. According to previous research reports, the prevalence rate of anaemia among Chinese adults is lacking. Additionally, the association between anaemia and four common an…
View article: Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis
Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis Open
Aims To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations. Methods and results Erythrocyte fatty acids …
View article: Effectiveness of telehealth pelvic-abdominal mechanics training rehabilitation program for pelvic floor rehabilitation in puerperal women: a randomized controlled study
Effectiveness of telehealth pelvic-abdominal mechanics training rehabilitation program for pelvic floor rehabilitation in puerperal women: a randomized controlled study Open
A pelvic-abdominal mechanics training rehabilitation program during the puerperium is safe and effective. Telemedicine is an extremely recommended means of pelvic floor rehabilitation during the puerperium.
View article: Long-term cardiovascular risk after severe exacerbation of chronic obstructive pulmonary disease: a population-based cohort study
Long-term cardiovascular risk after severe exacerbation of chronic obstructive pulmonary disease: a population-based cohort study Open
Background Exacerbation of chronic obstructive pulmonary disease (ECOPD) has been linked to increased cardiovascular disease (CVD) risk within the first year, yet longer risk is unclear. We aimed to investigate the short- and long-term CVD…
View article: Interactive effects of body mass index and physical activity on sleep quality in nursing students
Interactive effects of body mass index and physical activity on sleep quality in nursing students Open
Background Sleep problems are highly prevalent among nursing students, who often experience academic stress, irregular schedules, and heavy clinical training, which may negatively affect their physical and mental health as well as learning…
View article: Adverse Childhood Experiences and Antenatal Depression: The Mediating Role of Social Support
Adverse Childhood Experiences and Antenatal Depression: The Mediating Role of Social Support Open
The findings of this study suggest that ACEs have a pervasive impact on antenatal depression. Early intervention to prevent ACEs as well as improvements to the availability of social support for pregnant women should be provided to prevent…
View article: Effect modification of long-term air pollution exposure on the association of physical activity with COPD hospitalization: a prospective cohort study of 0.5 million Chinese adults
Effect modification of long-term air pollution exposure on the association of physical activity with COPD hospitalization: a prospective cohort study of 0.5 million Chinese adults Open
Sino-British Fellowship Trust, National Key Research and Development Program of China, Kadoorie Charitable Foundation, Wellcome, Noncommunicable Chronic Diseases-National Science and Technology Major Project, National Natural Science Found…
View article: SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study
SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study Open
Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors are guideline-recommended agents for treating heart failure (HF), but the role of metabolomic biomarkers in underlying mechanisms, particularly acylcarnitines, remains unclear. Th…
View article: Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults
Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults Open
Aims Little is known about the importance of blood lipids for risk of myocardial infarction (MI) in Chinese vs. European populations. We compared the associations with MI of apolioprotein B (ApoB) vs. low-density lipoprotein cholesterol (L…
View article: Patterns and correlates of visual impairment and ocular hypertension among older adults in the general Chinese population: results from the CKB Biobank
Patterns and correlates of visual impairment and ocular hypertension among older adults in the general Chinese population: results from the CKB Biobank Open
Background While numerous ophthalmology-specific cohort studies have been conducted in China, there is a significant lack of comprehensive, population-based study on the potential determinants of visual impairment and ocular hypertension (…
View article: Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study
Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study Open
Objective Poorly differentiated thyroid cancer (PDTC) is a rare, heterogeneous carcinoma from follicular cells, characterized by poor differentiation, aggressive spread, and poor prognosis. Currently, there is no specific staging system fo…
View article: Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design
Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design Open
Background Both obesity and DNA methylation (DNAm) are influenced by genetic factors. Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are…
View article: Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries
Multi-ancestry polygenic risk scores for the prediction of type 2 diabetes and complications in diverse ancestries Open
Summary Background Polygenic risk scores (PRSs) improve type 2 diabetes (T2D) prediction beyond clinical risk factors but perform poorly in non-European populations, where T2D burden is often higher, undermining their global clinical utili…