Qing‐Xiang Amy Sang
YOU?
Author Swipe
View article: Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes
Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes Open
Recent evidence indicates the presence of micro- and nanoplastics in the human brain, with higher accumulation observed in patients with dementia. However, their mechanistic effects on the human brain at the cellular level remain underexpl…
View article: Effects of Induced Pluripotent Stem Cell-Derived Astrocytes on Cisplatin Sensitivity in Pediatric Brain Cancer Cells
Effects of Induced Pluripotent Stem Cell-Derived Astrocytes on Cisplatin Sensitivity in Pediatric Brain Cancer Cells Open
Background: ATRTs and DIPGs are deadly pediatric brain tumors with poor prognosis. These tumors can develop resistance to chemotherapies, which may be significantly influenced by their microenvironment. Since astrocytes are the most abunda…
View article: Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence Open
Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, and increasing industrial production have led to questions about their long-term impact on human and animal health. This narrat…
View article: Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells
Feeder-free differentiation of human iPSCs into natural killer cells with cytotoxic potential against malignant brain rhabdoid tumor cells Open
Natural killer (NK) cells are cytotoxic immune cells that can eliminate target cells without prior stimulation. Human induced pluripotent stem cells (iPSCs) provide a robust source of NK cells for safe and effective cell-based immunotherap…
View article: Interconversion of Cancer Cells and Induced Pluripotent Stem Cells
Interconversion of Cancer Cells and Induced Pluripotent Stem Cells Open
Cancer cells, especially cancer stem cells (CSCs), share many molecular features with induced pluripotent stem cells (iPSCs) that enable the derivation of induced pluripotent cancer cells by reprogramming malignant cells. Conversely, norma…
View article: Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells
Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells Open
View article: TCGA RNA-Seq and Tumor-Infiltrating Lymphocyte Imaging Data Reveal Cold Tumor Signatures of Invasive Ductal Carcinomas and Estrogen Receptor-Positive Human Breast Tumors
TCGA RNA-Seq and Tumor-Infiltrating Lymphocyte Imaging Data Reveal Cold Tumor Signatures of Invasive Ductal Carcinomas and Estrogen Receptor-Positive Human Breast Tumors Open
Comparative studies of immune-active hot and immune-deserted cold tumors are critical for identifying therapeutic targets and strategies to improve immunotherapy outcomes in cancer patients. Tumors with high tumor-infiltrating lymphocytes …
View article: Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells
Modeling Human Brain Tumors and the Microenvironment Using Induced Pluripotent Stem Cells Open
Brain cancer is a group of diverse and rapidly growing malignancies that originate in the central nervous system (CNS) and have a poor prognosis. The complexity of brain structure and function makes brain cancer modeling extremely difficul…
View article: Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration
Macrophage-Conditioned Media Promotes Adipocyte Cancer Association, Which in Turn Stimulates Breast Cancer Proliferation and Migration Open
Background: Breast cancer is the most common cancer in women and the leading cause of female cancer deaths worldwide. Obesity causes chronic inflammation and is a risk factor for post-menopausal breast cancer and poor prognosis. Obesity tr…
View article: Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism
Effects of Polystyrene Microplastics on Human Kidney and Liver Cell Morphology, Cellular Proliferation, and Metabolism Open
Microplastics have gained much attention due to their prevalence and abundance in our everyday lives. They have been detected in household items such as sugar, salt, honey, seafood, tap water, water bottles, and food items wrapped in plast…
View article: Human Malignant Rhabdoid Tumor Antigens as Biomarkers and Potential Therapeutic Targets
Human Malignant Rhabdoid Tumor Antigens as Biomarkers and Potential Therapeutic Targets Open
Introduction: Atypical teratoid rhabdoid tumor (ATRT) is a lethal type of malignant rhabdoid tumor in the brain, seen mostly in children under two years old. ATRT is mainly linked to the biallelic inactivation of the SMARCB1 gene. To under…
View article: Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids
Phenotypic, metabolic, and biogenesis properties of human stem cell-derived cerebellar spheroids Open
Human cerebellum consists of high density and complexity of neurons. Thus, it is challenging to differentiate cerebellar-like organoids with similar cellular markers and function to the human brain. Our previous study showed that the combi…
View article: Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-Culture From Human Stem Cells
Studying the Inflammatory Responses to Amyloid Beta Oligomers in Brain-Specific Pericyte and Endothelial Co-Culture From Human Stem Cells Open
Background: Recently, the in vitro blood–brain barrier (BBB) models derived from human pluripotent stem cells have been given extensive attention in therapeutics due to the implications they have with the health of the central nervous syst…
View article: Cytochrome P450-2D6: A novel biomarker in liver cancer health disparity
Cytochrome P450-2D6: A novel biomarker in liver cancer health disparity Open
Liver cancer morbidity and mortality rates differ among ethnic groups. In the United States, the burden of liver cancer in Asian Americans (AS) is higher compared to Caucasian Americans (CA). Research on liver cancer health disparities has…
View article: Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration
Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration Open
Background Breast cancer is the most common cancer in women and the leading cause of female cancer deaths worldwide. Obesity causes chronic inflammation and is a risk factor for post-menopausal breast cancer and poor prognosis. Obesity tri…
View article: Biogenesis of Extracellular Vesicles Produced from Human-Stem-Cell-Derived Cortical Spheroids Exposed to Iron Oxides
Biogenesis of Extracellular Vesicles Produced from Human-Stem-Cell-Derived Cortical Spheroids Exposed to Iron Oxides Open
Stem-cell-derived extracellular vesicles (EVs) are promising tools for therapeutic delivery and imaging in the medical research fields. EVs that arise from endosomal compartments or plasma membrane budding consist of exosomes and microvesi…
View article: Advancements in Human Breast Cancer Targeted Therapy and Immunotherapy
Advancements in Human Breast Cancer Targeted Therapy and Immunotherapy Open
Human breast cancer treatment regimens have evolved greatly due to the significant advances in understanding the molecular mechanisms and pathways of the common subtypes of breast cancer. In this review, we discuss recent progress in breas…
View article: Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model. Open
First established by Dr. Leland W. K. Chung's lab, the androgen-repressed prostate cancer cell (ARCaP) line is derived from the ascitic fluid of a prostate cancer (PCa) patient with widely metastatic disease. Based on its unique characteri…
View article: Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration
Macrophage conditioned media promotes adipocyte cancer-association, which in turn stimulates breast cancer proliferation and migration Open
Background Breast cancer is the most common cancer in women and the leading cause of female cancer deaths worldwide. Obesity causes chronic inflammation and is a risk factor for post-menopausal breast cancer and poor prognosis. Obesity is …
View article: Clinical investigations of immunotherapy for human primary brain tumors
Clinical investigations of immunotherapy for human primary brain tumors Open
OAE Publishing Inc. is an international scholarly publisher specializing in peer-reviewed academic journals. To promote academic exchange and knowledge sharing, OAE provides an outstanding academic platform for biomedical experts and schol…
View article: Identifying county-level factors for female breast cancer incidence rate through a large-scale population study
Identifying county-level factors for female breast cancer incidence rate through a large-scale population study Open
View article: Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways
Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways Open
Differentiating cerebellar organoids can be challenging due to complex cell organization and structure in the cerebellum. Different approaches were investigated to recapitulate differentiation process of the cerebellum from human-induced p…
View article: Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype
Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype Open
Epithelial-mesenchymal transition (EMT) is a critical early step in cancer metastasis and a complex process that involves multiple factors. In this study, we used proteomics approaches to investigate the secreted proteins (secretome) of pa…
View article: Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
View article: Additional file 5 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 5 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 5. Differential gene expression of the clusters compared to normal adjacent tissues. Differential gene expression analysis using DESeq are shown along with p-values and log2 fold change.
View article: Additional file 8 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 8 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 8. Pathway analysis using GO for the tumor-tumor comparison.
View article: Additional file 7 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 7 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 7. Pathway analysis using KEGG pathway for the tumor-normal comparison.
View article: Additional file 4 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 4 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 4. Immune cell abundance for each patient in the 8 clusters. The abundance of immune cells was identified using CIBESORT for the patients in the identified clusters.
View article: Additional file 10 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 10 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 10. Differential gene expression for the analysis of the cancer-immunity pathway. The genes important for each step of the cancer immunity pathway were organized for the identification of the IEMs in each cluster.
View article: Additional file 11 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy
Additional file 11 of Immune landscape of human prostate cancer: immune evasion mechanisms and biomarkers for personalized immunotherapy Open
Additional file 11. Statistical analysis of immune cells. The differential abundance of cells between the clusters and normal tissue samples was done using pairwise T-test in R.