Qing Tian
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View article: Dual Subclavian-Brachiocephalic Artery Tortuosity and Its Impact on Procedural Efficiency in Trans-Radial Access Cerebral Angiography: A Retrospective Cohort Study
Dual Subclavian-Brachiocephalic Artery Tortuosity and Its Impact on Procedural Efficiency in Trans-Radial Access Cerebral Angiography: A Retrospective Cohort Study Open
Background: While trans-radial access (TRA) offers advantages in cerebral angiography, its efficiency is compromised by uncharacterized neurovascular anatomical barriers. This study investigates the impact of arterial tortuosity on procedu…
View article: Multimodal single-cell analysis reveals the prognostic role of myeloid subpopulation–driven PI3K/AKT signaling in hepatocellular carcinoma
Multimodal single-cell analysis reveals the prognostic role of myeloid subpopulation–driven PI3K/AKT signaling in hepatocellular carcinoma Open
Background: Hepatocellular carcinoma (HCC) represents a major global health burden, characterized by rising incidence, marked heterogeneity, and poor prognosis. Reliable biomarkers for prognostic stratification and therapeutic targeting re…
View article: Multi-Omics Integration Reveals Electroacupuncture Ameliorates Cognitive Impairment in Alzheimer’s Disease via Gut–Brain Axis
Multi-Omics Integration Reveals Electroacupuncture Ameliorates Cognitive Impairment in Alzheimer’s Disease via Gut–Brain Axis Open
Background: Alzheimer’s disease (AD) lacks effective therapeutic strategies. Electroacupuncture (EA) offers promising neuroprotective effects, but its underlying mechanisms remain unclear. Objective: To explore the mechanisms of EA’s neuro…
View article: Single-Cell Transcriptome Analysis Reveals the Expression Pattern of PDCD10 in Myeloid Cells of Hepatocellular Carcinoma and Its Correlation with Oxidative Stress, Immune Infiltration, and Immunotherapy Prognosis
Single-Cell Transcriptome Analysis Reveals the Expression Pattern of PDCD10 in Myeloid Cells of Hepatocellular Carcinoma and Its Correlation with Oxidative Stress, Immune Infiltration, and Immunotherapy Prognosis Open
Background: Hepatocellular carcinoma (HCC) is a highly malignant cancer with a poor prognosis. Its progression is significantly influenced by cellular heterogeneity, which complicates the understanding of its molecular mechanisms and contr…
View article: Lunar Surface Terrestrial Micro-Ecosystem Experimental System
Lunar Surface Terrestrial Micro-Ecosystem Experimental System Open
This paper briefly reviews the current state of domestic and international research on life science experiments related to lunar missions. It proposes a technical scheme for constructing a small terrestrial ecological experimental system o…
View article: PFedDST: Personalized Federated Learning with Decentralized Selection Training
PFedDST: Personalized Federated Learning with Decentralized Selection Training Open
Distributed Learning (DL) enables the training of machine learning models across multiple devices, yet it faces challenges like non-IID data distributions and device capability disparities, which can impede training efficiency. Communicati…
View article: Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk
Exploring genetic associations and drug targets for mitochondrial proteins and schizophrenia risk Open
View article: Integration of QuEChERS pretreatment and advanced liquid chromatography/mass spectrometry analysis for the broad-spectrum screening and simultaneous quantification of 15 mycotoxins in Citrus reticulata peel
Integration of QuEChERS pretreatment and advanced liquid chromatography/mass spectrometry analysis for the broad-spectrum screening and simultaneous quantification of 15 mycotoxins in Citrus reticulata peel Open
View article: Quantifying Topographic Shadow Effects on Vegetation Aspect Asymmetry in the Northern Hemisphere
Quantifying Topographic Shadow Effects on Vegetation Aspect Asymmetry in the Northern Hemisphere Open
View article: Breakthrough in enclosed aquatic ecosystems in space: Supporting zebrafish survival for 43 days
Breakthrough in enclosed aquatic ecosystems in space: Supporting zebrafish survival for 43 days Open
View article: The Mediating Role of Perceived Organizational Support in the Relationship Between Transformational Leadership and Knowledge Sharing Behavior of University Teachers in Universities
The Mediating Role of Perceived Organizational Support in the Relationship Between Transformational Leadership and Knowledge Sharing Behavior of University Teachers in Universities Open
In the era of knowledge economy, knowledge sharing has become a crucial social behavior that underpins the existence and development of a knowledge society. Encouraging university teachers to actively share their knowledge is essential for…
View article: Application Value and Safety Analysis of Warfarin, Rivaroxaban, and Dabigatran Ester in Elderly Patients With Atrial Fibrillation
Application Value and Safety Analysis of Warfarin, Rivaroxaban, and Dabigatran Ester in Elderly Patients With Atrial Fibrillation Open
Background This study aimed to evaluate the application value and safety of Warfarin, Rivaroxaban, and Dabigatran in elderly patients with atrial fibrillation. Methods A total of 180 elderly patients with atrial fibrillation admitted to ou…
View article: A staged approach using machine learning and uncertainty quantification to predict the risk of hip fracture
A staged approach using machine learning and uncertainty quantification to predict the risk of hip fracture Open
View article: Multi-dimension Transformer with Attention-based Filtering for Medical Image Segmentation
Multi-dimension Transformer with Attention-based Filtering for Medical Image Segmentation Open
The accurate segmentation of medical images is crucial for diagnosing and treating diseases. Recent studies demonstrate that vision transformer-based methods have significantly improved performance in medical image segmentation, primarily …
View article: Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy
Osteosarcoma-targeted Cu and Ce based oxide nanoplatform for NIR II fluorescence/magnetic resonance dual-mode imaging and ros cascade amplification along with immunotherapy Open
Background As the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis. Distinctive kinds of nanoplatform with high therapeutical effect and precise diagnosis for …
View article: Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice
Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice Open
Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive. In the f…
View article: Metastatic sacral chordoma to the liver: A case report
Metastatic sacral chordoma to the liver: A case report Open
View article: PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis
PPAN modulates mouse male germ cell development via maintaining nucleolar homeostasis Open
View article: An enhanced respiratory mechanics model based on double-exponential and fractional calculus
An enhanced respiratory mechanics model based on double-exponential and fractional calculus Open
We address mathematical modelling of respiratory mechanics and put forward a model based on double-exponential and fractional calculus for parameter estimation, model simulation, and evaluation based on actual data. Our model has been impl…
View article: Multi-view information fusion using multi-view variational autoencoder to predict proximal femoral fracture load
Multi-view information fusion using multi-view variational autoencoder to predict proximal femoral fracture load Open
Background Hip fracture occurs when an applied force exceeds the force that the proximal femur can support (the fracture load or “strength”) and can have devastating consequences with poor functional outcomes. Proximal femoral strengths fo…
View article: The unintended consequences of photodynamic therapy in cholangiocarcinoma: A case of septic shock
The unintended consequences of photodynamic therapy in cholangiocarcinoma: A case of septic shock Open
View article: Tau overload associated insufficient lysosomal hydrolysis activity through deacidification of lysosomes
Tau overload associated insufficient lysosomal hydrolysis activity through deacidification of lysosomes Open
Neuronal tau overload and lysosomal dysfunction are two pathological features in Alzheimer’s disease. Here, by ultra-high-resolution-fluorescence imaging and ultrastructural imaging, the lysosomes were observed larger in size, less numerou…
View article: Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia
Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia Open
The dried and ripe fruits of Alpinia oxyphylla and ripe fruits of Alpinia oxyphylla Miquel (AO) have the effects of tonifying kidney-essence and nourishing intelligence and thus have been widely used in treating dementia. Alzheimer’s disea…
View article: Arginine Reduces Glycation in γ2 Subunit of AMPK and Pathologies in Alzheimer’s Disease Model Mice
Arginine Reduces Glycation in γ2 Subunit of AMPK and Pathologies in Alzheimer’s Disease Model Mice Open
The metabolism disorders are a common convergence of Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM). The characteristics of AD are senile plaques and neurofibrillary tangles (NFTs) composed by deposits of amyloid−β (Aβ) and p…
View article: Multi-view information fusion using multi-view variational autoencoders to predict proximal femoral strength
Multi-view information fusion using multi-view variational autoencoders to predict proximal femoral strength Open
The aim of this paper is to design a deep learning-based model to predict proximal femoral strength using multi-view information fusion. Method: We developed new models using multi-view variational autoencoder (MVAE) for feature representa…
View article: Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes
Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes Open
Background Enhancer of zeste homologue 2 (EZH2), the core member of polycomb repressive complex 2 (PRC2), has multiple splicing modes and performs various physiological functions. However, function and mechanism of alternative splicing at …
View article: Transcriptome and DNA methylome analysis of peripheral blood samples reveals incomplete restoration and transposable element activation after 3-month recovery of COVID-19
Transcriptome and DNA methylome analysis of peripheral blood samples reveals incomplete restoration and transposable element activation after 3-month recovery of COVID-19 Open
Comprehensive analyses showed that SARS-CoV-2 infection caused COVID-19 and induced strong immune responses and sometimes severe illnesses. However, cellular features of recovered patients and long-term health consequences remain largely u…
View article: A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Chuanxiong Rhizoma in Alzheimer’s Disease
A Tau Pathogenesis-Based Network Pharmacology Approach for Exploring the Protections of Chuanxiong Rhizoma in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is the most common cause of neurodegenerative dementia and one of the top medical concerns worldwide. Currently, the approved drugs to treat AD are effective only in treating the symptoms, but do not cure or preven…
View article: Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts
Pathway-based metabolomics study of sarcopenia-related traits in two US cohorts Open
We aimed to validate two metabolites, aspartic acid and glutamic acid, which were associated with sarcopenia-related traits, muscle mass and strength, in our previous untargeted metabolomics study and to identify novel metabolites from fiv…
View article: Key Phytochemicals and Biological Functions of Chuanxiong Rhizoma Against Ischemic Stroke: A Network Pharmacology and Experimental Assessment
Key Phytochemicals and Biological Functions of Chuanxiong Rhizoma Against Ischemic Stroke: A Network Pharmacology and Experimental Assessment Open
Presently, the treatment options for ischemic stroke (IS) are limited due to the complicated pathological process of the disease. Chuanxiong Rhizome (CR), also known as Conioselinum anthriscoides “Chuanxiong” (rhizome), is the most widely …