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View article: The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study
The association between C-reactive protein-to-lymphocyte ratio and telomere length: A cross-sectional population-based study Open
The association of inflammation and telomere length (TL) have drawn much attention. However, the association between the C-reactive protein-to-lymphocyte ratio (CLR) and TL has never been reported before. The authors aimed to investigate t…
View article: HA/PCL scaffolds regulate bone regeneration by stimulating macrophage M2 phlarization
HA/PCL scaffolds regulate bone regeneration by stimulating macrophage M2 phlarization Open
Given that there are few reports on the immune modulation properties of 3D printed HA/PCL scaffolds with different hydroxyapatite(HA) ratios. Here, we applied 3D printing to prepare PCL scaffolds with different HA contents: P, HP (2:10), H…
View article: Immunomodulation and bone repair of 3D printed Seb/PCL scaffolds containing PDA coating
Immunomodulation and bone repair of 3D printed Seb/PCL scaffolds containing PDA coating Open
3D-printed polycaprolactone (PCL) scaffolds are widely used for bone tissue engineering but suffer from deficiencies such as difficulty in cell adhesion, lack of osteogenic activity, and immunomodulatory capacity. Enhancing the biological …
View article: Recent advances in understanding the role of Wnt5a in prostate cancer and bone metastasis
Recent advances in understanding the role of Wnt5a in prostate cancer and bone metastasis Open
Prostate cancer (PCa) is a leading cause of cancer-related mortality in men, with a high propensity for bone metastasis that significantly impairs patient quality of life. The Wnt5a signaling pathway plays a pivotal role in the progression…
View article: 3D printing hydroxyapatite/nanoclay/polycaprolactone composite scaffold for immune regulation and promoting bone defect healing
3D printing hydroxyapatite/nanoclay/polycaprolactone composite scaffold for immune regulation and promoting bone defect healing Open
Excessive inflammation is one of the major causes of failure in the clinical repair of critical-sized bone defects, and the immune microenvironment plays a pivotal role in osteogenesis. An appropriate local immune response following biomat…
View article: 3D printing of different fibres towards HA/PCL scaffolding induces macrophage polarization and promotes osteogenic differentiation of BMSCs
3D printing of different fibres towards HA/PCL scaffolding induces macrophage polarization and promotes osteogenic differentiation of BMSCs Open
With the rise of bone tissue engineering (BET), 3D-printed HA/PCL scaffolds for bone defect repair have been extensively studied. However, little research has been conducted on the differences in osteogenic induction and regulation of macr…
View article: Latent profiles and determinants of postoperative sleep quality in elective surgery patients
Latent profiles and determinants of postoperative sleep quality in elective surgery patients Open
It is crucial to determine the potential subgroups of sleep disturbances in patients undergoing elective surgery based on the importance of symptom clusters and individual characteristics in order to develop targeted symptom management pla…
View article: Polydopamine-modified 3D printed polycaprolactone scaffolds promote bone regeneration
Polydopamine-modified 3D printed polycaprolactone scaffolds promote bone regeneration Open
Polycaprolactone (PCL) is one of the most widely used 3D printing materials with good biocompatibility and mechanical properties, but its hydrophobic properties are detrimental to cell adhesion and proliferation. Studies have shown that po…
View article: Latent profile analysis and influencing factors of postoperative sleep quality among elective surgery patients
Latent profile analysis and influencing factors of postoperative sleep quality among elective surgery patients Open
It is crucial to determine the potential subgroups of sleep disorders in patients undergoing elective surgery based on the importance of symptom clusters and individual characteristics in order to develop targeted symptom management plans.…
View article: 3D-Printed mesoporous bioglass/ polycaprolactone scaffolds induce macrophage polarization toward M2 phenotype and immunomodulates osteogenic differentiation of BMSCs
3D-Printed mesoporous bioglass/ polycaprolactone scaffolds induce macrophage polarization toward M2 phenotype and immunomodulates osteogenic differentiation of BMSCs Open
Bioceramic composite polycaprolactone (PCL) scaffolds are widely used in bone defect repair studies. Among them, bioactive glass (BG) is considered an excellent bone-based repair material due to its unique inorganic amorphous structure, bi…
View article: Different therapeutic regimens in the treatment of metastatic prostate cancer
Different therapeutic regimens in the treatment of metastatic prostate cancer Open
Dear Editor, With great interest, we read an article entitled 'Different therapeutic regimens in the treatment of metastatic prostate cancer' in your precious journal1. This meta-analysis included 17 observational studies to conduct a netw…
View article: Salvianolic Acid B Suppresses ER Stress‐Induced NLRP3 Inflammasome and Pyroptosis via the AMPK/FoxO4 and Syndecan‐4/Rac1 Signaling Pathways in Human Endothelial Progenitor Cells
Salvianolic Acid B Suppresses ER Stress‐Induced NLRP3 Inflammasome and Pyroptosis via the AMPK/FoxO4 and Syndecan‐4/Rac1 Signaling Pathways in Human Endothelial Progenitor Cells Open
Mounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress responses can activate the inflammasome, which generally results in endothelial dysfunction, a major pathogenetic factor of chronic inflammatory diseases such as…
View article: Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines
Perillaldehyde inhibits bone metastasis and receptor activator of nuclear factor-κB ligand (RANKL) signaling-induced osteoclastogenesis in prostate cancer cell lines Open
Perillaldehyde (PAH), one of the active ingredients of the traditional Chinese medicine (TCM) plant Perilla frutescens, is widely used and exerts crucial anti-cancer activities. The aim of current study is to illustrate the potential mecha…
View article: Circ_HECW2 regulates LPS‐induced apoptosis of chondrocytes via miR‐93 methylation
Circ_HECW2 regulates LPS‐induced apoptosis of chondrocytes via miR‐93 methylation Open
Introduction Circ_HECW2 plays a key role in lipopolysaccharide (LPS)‐induced signal transduction, which is critical in osteoarthritis (OA). Thus, we analyzed the role of Circ_HECW2 in osteoarthritis. Methods The expression of Circ_HECW2 an…
View article: Incidence and Prognosis of Bone Metastases in Common Solid Cancers at Initial Diagnosis: A Population-Based Study
Incidence and Prognosis of Bone Metastases in Common Solid Cancers at Initial Diagnosis: A Population-Based Study Open
Background Bone is one of the most common sites of advanced tumors. However, there is currently a lack of population-based surveys for the incidence and prognosis of bone metastases in common solid cancers.Methods Patients with 12 types of…
View article: miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2
miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2 Open
MicroRNAs (miRs) are involved in several physiological processes, including chondrogenic differentiation, however, their expression and roles in the chondrogenic differentiation of human adipose‑derived stem cells (hADSCs) remain to be ful…
View article: Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling
Transcriptional downregulation of miR-133b by REST promotes prostate cancer metastasis to bone via activating TGF-β signaling Open
High avidity of bone metastasis is an important characteristic in prostate cancer (PCa). Downexpression of miR-133b has been reported to be implicated in the development, progression and recurrence in PCa. However, clinical significance an…
View article: miR‑328‑3p enhances the radiosensitivity of osteosarcoma and regulates apoptosis and cell viability via H2AX
miR‑328‑3p enhances the radiosensitivity of osteosarcoma and regulates apoptosis and cell viability via H2AX Open
Osteosarcoma is a kind of high-risk sarcoma of the skeleton typically observed in people under 25 years old. Currently, radiotherapy is widely applied in cancer treatment. However, osteosarcoma is radioresistant and accordingly new, more e…
View article: Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer
Downregulation of miR‑19a‑3p promotes invasion, migration and bone metastasis via activating TGF‑β signaling in prostate cancer Open
Constitutive activation of TGF‑β signaling pathway is a well-documented mechanism responsible for the bone metastasis of prostate cancer (PCa). MicroRNAs (miRNAs) have been reported to be crucial for the activation of TGF‑β signaling via t…
View article: miR-30b regulates chondrogenic differentiation of mouse embryo‑derived stem cells by targeting SOX9
miR-30b regulates chondrogenic differentiation of mouse embryo‑derived stem cells by targeting SOX9 Open
The present study aimed to investigate the mechanisms underlying microRNA (miRNA)-mediated regulation of chondrogenic differentiation. Mouse embryo-derived stem cells C3H10T1/2 were cultured and chondrogenic differentiation was induced usi…