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View article: Reoviridae-derived short trimerization domain for stabilizing homo-trimerization of vaccine immunogens and therapeutic proteins
Reoviridae-derived short trimerization domain for stabilizing homo-trimerization of vaccine immunogens and therapeutic proteins Open
Trimerization motifs play pivotal roles in structural biology and therapeutic protein engineering. Here, we engineered a novel short trimerization motif (rFd1303) derived from the Reoviridae family reovirus σ1 protein. Compared with the wi…
View article: XA-Novo: an accurate and high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures
XA-Novo: an accurate and high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures Open
Elucidating antibody sequences by mass spectrometry (MS)-based de novo sequencing is essential but challenging. Herein, we propose XA-Novo, an accurate, robust, high-throughput de novo sequencing solution that integrates a single-pot multi…
View article: A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants
A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants Open
The ongoing co-circulation of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains necessitates advanced methods such as high-throughput multiplex pseudovirus systems for evaluating immune responses to different va…
View article: Simplified and Rapid Workflow Enhances Throughput of<i>De Novo</i>Sequencing of COVID-19 Neutralizing Antibodies
Simplified and Rapid Workflow Enhances Throughput of<i>De Novo</i>Sequencing of COVID-19 Neutralizing Antibodies Open
During the current COVID-19 pandemic, precise antibody sequencing is crucial for the rapid development of broad-spectrum or pan-β-coronavirus neutralizing antibodies (NAbs) to prevent new variants of the coronavirus and other highly pathog…