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View article: Catalpalactone protects rats nerve function from hypoxic lesion by polarizing microglial cells toward M2 phenotype
Catalpalactone protects rats nerve function from hypoxic lesion by polarizing microglial cells toward M2 phenotype Open
We clarified the underlying mechanism of Catalpalactone treatment for ischemic lesions through promoting M2 microglial cells phenotype.
View article: An Empirical Characterization of Outages and Incidents in Public Services for Large Language Models
An Empirical Characterization of Outages and Incidents in Public Services for Large Language Models Open
People and businesses increasingly rely on public LLM services, such as ChatGPT, DALLE, and Claude. Understanding their outages, and particularly measuring their failure-recovery processes, is becoming a stringent problem. However, only li…
View article: From technique mastery to scientific thinking: how open-ended experiments shape medical students' perception of laboratory course roles in China
From technique mastery to scientific thinking: how open-ended experiments shape medical students' perception of laboratory course roles in China Open
This study revealed that medical students' perceptions of the roles of laboratory courses were influenced by experimental teaching methods. Open-ended experiments have emerged as effective tools for fostering scientific thinking. This rese…
View article: Structural, functional, and immunogenicity implications of <i>F9</i> gene recoding
Structural, functional, and immunogenicity implications of <i>F9</i> gene recoding Open
Hemophilia B is a blood clotting disorder caused by deficient activity of coagulation factor IX (FIX). Multiple recombinant FIX proteins are currently approved to treat hemophilia B, and several gene therapy products are currently being de…
View article: Effects of different cultivation strategies on soil nutrients and bacterial diversity in kiwifruit orchards
Effects of different cultivation strategies on soil nutrients and bacterial diversity in kiwifruit orchards Open
The basic principle underlying organic orchards is increased soil nutrient content, particularly organic matter content and increases soil bacterial activity and diversity.A standard organic management stratep < 0.05) soil alkaline phospha…
View article: Molecular cloning, expression, and functional features of IGF1 splice variants in sheep
Molecular cloning, expression, and functional features of IGF1 splice variants in sheep Open
Insulin-like growth factor 1 (IGF1), also known as somatomedin C, is essential for the regulation of animal growth and development. In many species, the IGF1 gene can be alternatively spliced into multiple transcripts, encoding different p…
View article: Identification of the potential roles of ring finger protein 8 in TP53‑mutant breast cancer
Identification of the potential roles of ring finger protein 8 in TP53‑mutant breast cancer Open
Breast cancer is one of the malignant tumors with the highest mortality rate. With the development of precise treatment technology for cancer, numerous molecular targets have been identified and applied in the treatment of diseases. The pr…
View article: Adeno-Associated Virus-Mediated Overexpression of LARGE Rescues α-Dystroglycan Function in Dystrophic Mice with Mutations in the Fukutin-Related Protein
Adeno-Associated Virus-Mediated Overexpression of LARGE Rescues α-Dystroglycan Function in Dystrophic Mice with Mutations in the Fukutin-Related Protein Open
Multiple genes (e.g., POMT1, POMT2, POMGnT1, ISPD, GTDC2, B3GALNT2, FKTN, FKRP, and LARGE) are known to be involved in the glycosylation pathway of α-dystroglycan (α-DG). Mutations of these genes result in muscular dystrophies with wide ph…
View article: [Significance and current development status of pediatric palliative care].
[Significance and current development status of pediatric palliative care]. Open
Pediatric palliative care refers to the comprehensive physical, mental, and psychological care provided to the children with life-threatening diseases, as well as support for their families, aiming to provide the best quality of life for c…
View article: BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice
BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice Open
Factor VIII (FVIII) replacement products enable comprehensive care in hemophilia A. Treatment goals in severe hemophilia A are expanding beyond low annualized bleed rates to include long-term outcomes associated with high sustained FVIII l…
View article: The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis
The von Willebrand factor D′D3 assembly and structural principles for factor VIII binding and concatemer biogenesis Open
D assemblies make up half of the von Willebrand factor (VWF), yet are of unknown structure. D1 and D2 in the prodomain and D′D3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerization of D3 thro…
View article: Peripheral inflammation/immune indicators of chemosensitivity and prognosis in breast cancer patients treated with neoadjuvant chemotherapy
Peripheral inflammation/immune indicators of chemosensitivity and prognosis in breast cancer patients treated with neoadjuvant chemotherapy Open
We demonstrated that a high level of baseline peripheral lymphocyte count can be a predictor for high efficacy of NAC for breast cancer patients, and low baseline peripheral neutrophil count may contribute to the favorable disease-free sur…
View article: Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B
Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B Open
Background Haemophilia B is caused by genetic aberrations in the F9 gene. The majority of these are non-synonymous mutations that alter the primary structure of blood coagulation factor IX (FIX). However, a synonymous mutation c.459G>A (Va…