Qinggui Liu
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View article: Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis
Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis Open
Pericentral senescent hepatocytes secrete CLU to induce the proliferation and migration of mesothelial cells to endocytose fibers by its receptor LRP2, thus reducing liver fibrosis. The engineered CLUtide mimicking CLU may be promising for…
View article: The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases
The double-edged effects of IL-6 in liver regeneration, aging, inflammation, and diseases Open
View article: Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells
Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells Open
Taken together, these findings pointed that induction of senescence in liver CSCs is an effective tumor suppression method for HCC, and SIRT1 may be served as a promising target for HCC treatment.
View article: Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy
Aged-related Function Disorder of Liver is Reversed after Exposing to Young Milieu via Conversion of Hepatocyte Ploidy Open
Previous study showed that senescent hepatocytes from aged liver could be rejuvenated after repopulated in the young recipient liver. The proliferative capacity of hepatocytes was restored with the senescence reversal. However, it is unkno…
View article: Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro
Generation of insulin-secreting cells from mouse gallbladder stem cells by small molecules in vitro Open
View article: Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging Open
Although aging is a physiological process, it has raised interest in the science of aging and rejuvenation because of the increasing burden on the rapidly aging global population. With advanced age, there is a decline in homeostatic mainte…
View article: Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice
Insulin-like growth factor 2 is a key mitogen driving liver repopulation in mice Open