Qinghui Ou
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View article: CD36-Retinoic Acid- FABP5- PPARδ Signaling Axis Primes Neonatal Cardiomyocytes to Spontaneously Proliferate
CD36-Retinoic Acid- FABP5- PPARδ Signaling Axis Primes Neonatal Cardiomyocytes to Spontaneously Proliferate Open
View article: Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity Open
View article: A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine
A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine Open
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically pre…
View article: A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine
A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine Open
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically pre…
View article: XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity
XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity Open
BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited. Intramyocardial lipotoxic…
View article: Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity Open
View article: Intravenous infusions of mesenchymal stromal cells have cumulative beneficial effects in a porcine model of chronic ischaemic cardiomyopathy
Intravenous infusions of mesenchymal stromal cells have cumulative beneficial effects in a porcine model of chronic ischaemic cardiomyopathy Open
Aims The development of cell therapy as a widely available clinical option for ischaemic cardiomyopathy is hindered by the invasive nature of current cell delivery methods. Furthermore, the rapid disappearance of cells after transplantatio…
View article: PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy<i>Short Title: PAK3 provokes cardiac lipotoxicity</i>
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy<i>Short Title: PAK3 provokes cardiac lipotoxicity</i> Open
AbstractObesity-induced lipid overload in cardiomyocytes contributes to profound oxidative stress and cardiomyopathy, culminating in heart failure. In this study, we investigate a novel mechanism whereby lipids accumulate in cardiom…
View article: PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy<i>Short Title: PAK3 provokes cardiac lipotoxicity</i>
PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy<i>Short Title: PAK3 provokes cardiac lipotoxicity</i> Open
AbstractObesity-induced lipid overload in cardiomyocytes contributes to profound oxidative stress and cardiomyopathy, culminating in heart failure. In this study, we investigate a novel mechanism whereby lipids accumulate in cardiom…
View article: Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats
Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats Open
Aims Gene therapies to induce cardiomyocyte (CM) cell cycle re-entry have shown a potential to treat subacute ischaemic heart failure (IHF) but have not been tested in the more relevant setting of chronic IHF. Our group recently showed tha…
View article: Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity.
Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity. Open
View article: Restored autophagy is protective against PAK3-induced cardiac dysfunction
Restored autophagy is protective against PAK3-induced cardiac dysfunction Open
Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was augmented in failing human and mouse hearts. Furthermore, mice with cardiac-specific P…
View article: FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress
FGF21/FGFR1-β-KL cascade in cardiomyocytes modulates angiogenesis and inflammation under metabolic stress Open
Diabetes is a metabolic disorder with an increased risk of developing heart failure. Inflammation and damaged vasculature are the cardinal features of diabetes-induced cardiac damage. Moreover, systemic metabolic stress triggers discordant…
View article: Restored Autophagy is Protective Against PAK3-Induced Cardiac Dysfunction
Restored Autophagy is Protective Against PAK3-Induced Cardiac Dysfunction Open
View article: Transient gene therapy using cell cycle factors reverses renin–angiotensin–aldosterone system activation in heart failure rat model
Transient gene therapy using cell cycle factors reverses renin–angiotensin–aldosterone system activation in heart failure rat model Open
View article: PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction
PU.1 inhibition does not attenuate cardiac function deterioration or fibrosis in a murine model of myocardial infarction Open
View article: Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo
Biomimetic cardiac tissue culture model (CTCM) to emulate cardiac physiology and pathophysiology ex vivo Open
There is need for a reliable in vitro system that can accurately replicate the cardiac physiological environment for drug testing. The limited availability of human heart tissue culture systems has led to inaccurate interpretations of card…
View article: Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy
Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy Open
View article: Biomimetic Cardiac Tissue Culture Model (CTCM) to Emulate Cardiac Physiology and Pathophysiology ex vivo
Biomimetic Cardiac Tissue Culture Model (CTCM) to Emulate Cardiac Physiology and Pathophysiology ex vivo Open
Background: There is an urgent need for a reliable in vitro system that can accurately replicate the cardiac physiological environment for drug testing. The limited availability of human heart tissue culture systems has led to inaccurate i…
View article: FGF21/FGFR1-β-KL Cascade in Cardiomyocytes Modulates Angiogenesis and Inflammation Under Metabolic Stress
FGF21/FGFR1-β-KL Cascade in Cardiomyocytes Modulates Angiogenesis and Inflammation Under Metabolic Stress Open
View article: Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation
Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation Open
These findings suggest that a metabolic shift from catabolic to anabolic activity is a critical step for cardiomyocyte cell cycle entry and is required to facilitate proliferation.
View article: Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart Failure
Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart Failure Open
The regenerative capacity of the heart after myocardial infarction (MI) is limited. Our previous study showed that ectopic introduction of Cdk1/CyclinB1 and Cdk4/CyclinD1 complexes (4F) promotes cardiomyocyte proliferation in 15-20% of inf…
View article: Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity
Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity Open
View article: Heart Slice Culture System Reliably Demonstrates Clinical Drug-Related Cardiotoxicity
Heart Slice Culture System Reliably Demonstrates Clinical Drug-Related Cardiotoxicity Open
The limited availability of human heart tissue and its complex cell composition are major limiting factors for reliable testing drug efficacy, toxicity and understanding mechanism. Recently, we developed a functional human and pig heart sl…
View article: Slicing and Culturing Pig Hearts under Physiological Conditions
Slicing and Culturing Pig Hearts under Physiological Conditions Open
Many novel drugs fail in clinical studies due to cardiotoxic side effects as the currently available in vitro assays and in vivo animal models poorly predict human cardiac liabilities, posing a multi-billion-dollar burden on the pharmaceut…
View article: Physiological Biomimetic Culture System for Pig and Human Heart Slices
Physiological Biomimetic Culture System for Pig and Human Heart Slices Open
Rationale: Preclinical testing of cardiotoxicity and efficacy of novel heart failure therapies faces a major limitation: the lack of an in situ culture system that emulates the complexity of human heart tissue and maintains viability and f…
View article: Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose
Repeated Administrations of Cardiac Progenitor Cells Are Superior to a Single Administration of an Equivalent Cumulative Dose Open
Background We have recently found that 3 repeated doses (12×10 6 each) of c‐kit POS cardiac progenitor cells ( CPC s) were markedly more effective than a single dose of 12×10 6 cells in alleviating postinfarction left ventricular dysfuncti…
View article: Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration
Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration Open
Rationale: The effects of c-kit POS cardiac progenitor cells (CPCs, and adult cell therapy in general) on left ventricular (LV) function have been regarded as modest or inconsistent. Objective: To determine whether 3 CPC infusions have gre…
View article: 178. Effect of Heme Oxygenase-1 Overexpression on DNA Synthesis of Adult Cardiac Progenitor Cells Under Hypoxia
178. Effect of Heme Oxygenase-1 Overexpression on DNA Synthesis of Adult Cardiac Progenitor Cells Under Hypoxia Open
Although the studies in animals and humans have shown that the beneficial effects of adult c-kit+ cardiac progenitor cells (CPCs) on left ventricle function and remodeling post-myocardial infarction persist for several weeks and up to 1 ye…
View article: Long-Term Outcome of Administration of c-kit <sup>POS</sup> Cardiac Progenitor Cells After Acute Myocardial Infarction
Long-Term Outcome of Administration of c-kit <sup>POS</sup> Cardiac Progenitor Cells After Acute Myocardial Infarction Open
Rationale: Cardiac progenitor cells (CPCs) improve left ventricular remodeling and function after acute or chronic myocardial infarction. However, the long-term (>5 weeks) effects, potential tumorigenicity, and fate of transplanted CPCs ar…