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View article: FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway
FAM84B, amplified in pancreatic ductal adenocarcinoma, promotes tumorigenesis through the Wnt/β-catenin pathway Open
Altered expression of family with sequence similarity 84, member B (FAM84B) has been found in various human cancers. However, the expression and function of FAM84B in pancreatic ductal adenocarcinoma (PDAC) has not been studied. Here, by a…
View article: MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin β1
MiR-760 enhances sensitivity of pancreatic cancer cells to gemcitabine through modulating Integrin β1 Open
Pancreatic cancer (PC) is the most lethal tumor type among human diseases, with low survival rate. The investigation of potent molecular mechanisms involved in PC is still obscure owing to its drug resistance. The purpose of the present st…
View article: Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions
Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions Open
Gastrointestinal stromal tumors (GISTs) are the most common sarcomas in humans. Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine kinases are the initiating oncogenic events. Most metastatic GISTs respond dramatica…
View article: Low tristetraprolin expression promotes cell proliferation and predicts poor patients outcome in pancreatic cancer
Low tristetraprolin expression promotes cell proliferation and predicts poor patients outcome in pancreatic cancer Open
Tristetraprolin (also known as TTP, TIS11, ZFP36, and Nup475) is a well-characterized tumor suppressor that is down-regulated in several tumor types. In the current study, we found that TTP expression was markedly reduced in pancreatic can…
View article: Carboxy-terminal domain phosphatase 1 silencing results in the inhibition of tumor formation ability in gastric cancer cells
Carboxy-terminal domain phosphatase 1 silencing results in the inhibition of tumor formation ability in gastric cancer cells Open
Gastric cancer (GC), one of the most malignant types of cancer, is the second greatest cause of cancer-associated mortality worldwide. Novel therapeutic targets for GC treatment are therefore urgently required. Carboxy-terminal domain phos…
View article: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma
Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma Open
Our results indicate that decreased expression of CA7 correlates with disease progression and predicts poor prognosis in CRC, especially for patients with early stage tumors.
View article: <i>Retracted:</i> Tumor Protein D52-Like 2 Accelerates Gastric Cancer Cell Proliferation <i>In Vitro</i>
<i>Retracted:</i> Tumor Protein D52-Like 2 Accelerates Gastric Cancer Cell Proliferation <i>In Vitro</i> Open
Tumor protein D52-like 2 (TPD52L2) has been commonly described as a protein involved in tumorigenesis, according to its name. However, its pathological function remains under investigation. In the present study, TPD52L2 was found to be wid…