Qin Du
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View article: Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial
Tegoprazan-based versus esomeprazole-based triple therapy plus bismuth for first-line Helicobacter pylori eradication: A nationwide, multicenter, double-blind, double-dummy, randomized controlled trial Open
Background: Although triple therapy plus bismuth (TTPB), comprising a proton pump inhibitor (PPI), two antibiotics, and bismuth, is widely used to eradicate Helicobacter pylori ( H. pylori ), eradication rates have been suboptimal. Potassi…
View article: Assessing the categories and influencing factors of the professional identity among new nurses: a latent profile analysis
Assessing the categories and influencing factors of the professional identity among new nurses: a latent profile analysis Open
The professional identity of new nurses exhibits considerable heterogeneity, with 71.4% falling into the low-identification/apathetic category. Managers should focus on supporting nurses with lower professional identity. Psychological resi…
View article: p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization
p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization Open
Temporomandibular joint osteoarthritis (TMJOA), sometimes combined with type 2 diabetes (T2DM-TMJOA), has a restricting effect on quality of life and currently has few efficacious treatment options. As such, this project sought to determin…
View article: Research on the Categories and Influencing Factors of the Professional Identity of New Nurses: A Latent Profile Analysis
Research on the Categories and Influencing Factors of the Professional Identity of New Nurses: A Latent Profile Analysis Open
Background: This study aims to explore the latent classes of professional identity among new nurses and to identify the factors influencing their professional identity. Methods: A convenience sampling method was employed to recruit 256 new…
View article: Vonoprazan-based quadruple therapy is non-inferior to esomeprazole-based quadruple therapy for Helicobacter pylori eradication: A multicenter, double-blind, randomized, phase 3 study
Vonoprazan-based quadruple therapy is non-inferior to esomeprazole-based quadruple therapy for Helicobacter pylori eradication: A multicenter, double-blind, randomized, phase 3 study Open
Background: Owing to the high prevalence of antibiotic resistance in Helicobacter pylori ( H. pylori ) in China, bismuth-containing quadruple therapies have been recommended for H. pylori eradication. This study compared the efficacy and s…
View article: Paediatric varicella epidemiology in urban Beijing, China, 2014–2023
Paediatric varicella epidemiology in urban Beijing, China, 2014–2023 Open
Data on the clinical epidemiology of varicella in Beijing, China, remain limited. Here, we present an analysis of paediatric varicella cases from 2014 to 2023, including 10,049 cases from two children's hospitals. A gradual decline in the …
View article: Environmental drivers of herbaceous plant diversity in the understory community of a warm-temperate forest
Environmental drivers of herbaceous plant diversity in the understory community of a warm-temperate forest Open
Herbaceous plants are an essential component of forest diversity and driver of ecosystem processes. However, because the growth forms and life-history strategies of herbaceous plants differ from those of woody plants, it is unclear whether…
View article: Real-Time Evaluation of Helicobacter pylori Infection by Convolution Neural Network During White-Light Endoscopy: A Prospective, Multicenter Study (With Video)
Real-Time Evaluation of Helicobacter pylori Infection by Convolution Neural Network During White-Light Endoscopy: A Prospective, Multicenter Study (With Video) Open
INTRODUCTION: Convolutional neural network during endoscopy may facilitate evaluation of Helicobacter pylori infection without obtaining gastric biopsies. The aim of the study was to evaluate the diagnosis accuracy of a computer-aided deci…
View article: The dilemma and the way out of the construction of the law profession in the context of new liberal arts based on an intelligent legal learning system
The dilemma and the way out of the construction of the law profession in the context of new liberal arts based on an intelligent legal learning system Open
Due to society’s practical demands, the legal profession’s growth within the context of the new liberal arts is necessary to improve teaching mechanisms and the comprehensive development of interdisciplinarity. In this paper, from the two …
View article: Optimal Cutoffs for the Diagnosis of Sarcopenia in Older Chinese Adults
Optimal Cutoffs for the Diagnosis of Sarcopenia in Older Chinese Adults Open
Background The optimal criteria for sarcopenia in the older Chinese population have not been defined. Consequently, this study aims to determine the optimal cutoffs of grip strength, appendicular skeletal muscle index (ASMI) using bioelect…
View article: Brain structural and functional connectivity alterations are associated with fatigue in neuromyelitis optica spectrum disorder
Brain structural and functional connectivity alterations are associated with fatigue in neuromyelitis optica spectrum disorder Open
Background Many patients with neurological disorders experience chronic fatigue, but the neural mechanisms involved are unclear. Objective Here we investigated whether the brain structural and functional connectivity alterations were invol…
View article: Mucosal Healing Effectiveness and Safety of Anaprazole, a Novel PPI, vs. Rabeprazole in Patients With Duodenal Ulcers: A Randomized Double-Blinded Multicenter Phase II Clinical Trial
Mucosal Healing Effectiveness and Safety of Anaprazole, a Novel PPI, vs. Rabeprazole in Patients With Duodenal Ulcers: A Randomized Double-Blinded Multicenter Phase II Clinical Trial Open
Background: Proton pump inhibitors (PPIs) are validated gastric acid suppressors and have been widely used to treat patients with active duodenal ulcers. Although existing PPIs have shown great efficacy, many scientists are still devoted t…
View article: A method to alleviate false-positive results of the Elecsys HIV combi PT assay
A method to alleviate false-positive results of the Elecsys HIV combi PT assay Open
To explore the effects of urea dissociation on reducing false-positive results of the Elecsys HIV combi PT assay. A retrospective analysis was used to evaluate the false-positive rate of the Elecsys HIV combi PT assay. Six false-positive s…
View article: Ecological planning strategies for urban parks based on biodiversity conservation and promotion: a case study of Qingxiushan Forest Park in Nanning City
Ecological planning strategies for urban parks based on biodiversity conservation and promotion: a case study of Qingxiushan Forest Park in Nanning City Open
Urban biodiversity plays an important role in maintaining urban ecosystem, beautifying urban environment, improving economic benefits and human well-being, and urban park, as an important habitat of urban biology, is an important part of u…
View article: Mechanism of heparin interference in detection of LIAISON® Rubella IgM
Mechanism of heparin interference in detection of LIAISON® Rubella IgM Open
Plasma with heparin cannot be used to the detection of LIAISON® Rub-M. Heparin may participate in the reaction by binding with rubella virus antigen and anti-human IgM-specific antibodies coated on the surface of magnetic particle, thus af…
View article: <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methylation signature as a predictor of stomach adenocarcinoma outcomes and its association with immune checkpoint molecules
<i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) RNA methylation signature as a predictor of stomach adenocarcinoma outcomes and its association with immune checkpoint molecules Open
Objective Although N 6 -methyladenosine (m 6 A) RNA methylation is the most common mRNA modification process, few studies have examined the role of m 6 A in stomach adenocarcinomas (STADs). Methods In this retrospective study, we analyzed …
View article: Diagnostic value of the γ-glutamyltransferase and alanine transaminase ratio, alpha-fetoprotein, and protein induced by vitamin K absence or antagonist II in hepatitis B virus-related hepatocellular carcinoma
Diagnostic value of the γ-glutamyltransferase and alanine transaminase ratio, alpha-fetoprotein, and protein induced by vitamin K absence or antagonist II in hepatitis B virus-related hepatocellular carcinoma Open
Hepatocellular carcinoma is a common type of malignancy with a poor prognosis. Identification and utilisation of markers for monitoring and diagnosis are urgently needed. Alpha-fetoprotein (AFP) and Protein Induced by Vitamin K Absence or …
View article: A Method To Prevent SARS-CoV-2 IgM False Positives in Gold Immunochromatography and Enzyme-Linked Immunosorbent Assays
A Method To Prevent SARS-CoV-2 IgM False Positives in Gold Immunochromatography and Enzyme-Linked Immunosorbent Assays Open
We set out to investigate the interference factors that led to false-positive novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgM detection results using gold immunochromatography assay (GICA) and enzyme-linked immunosor…
View article: Biodiversity protection and ecological restoration of Guilin Karst quarry
Biodiversity protection and ecological restoration of Guilin Karst quarry Open
The abandoned quarry as a witness left by industrial history has greatly damaged the mining area and the surrounding ecological environment, causing severe disturbances on the surface, soil erosion and biodiversity decline. Therefore, the …
View article: Analysis of Urban Greenway Planning Strategies by The Orientation of Healthy City
Analysis of Urban Greenway Planning Strategies by The Orientation of Healthy City Open
In the first half-year of 2020, the COVID-19 (Coronavirus disease 2019) outbreak spread rapidly around the world. Under the impact of the crisis of Public Health Emergency, the development of healthy cities and people’s lives must be exper…
View article: Long-term follow-up of <i>Helicobacter pylori</i> reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study
Long-term follow-up of <i>Helicobacter pylori</i> reinfection and its risk factors after initial eradication: a large-scale multicentre, prospective open cohort, observational study Open
Helicobacter pylori (H. pylori) recurrence remains a significant public health concern. The study aimed to assess H. pylori reinfection rate and identify its risk factors in China. This prospective open cohort, observational study was perf…
View article: Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma
Diagnostic value of gamma-glutamyltransferase/aspartate aminotransferase ratio, protein induced by vitamin K absence or antagonist II, and alpha-fetoprotein in hepatitis B virus-related hepatocellular carcinoma Open
The γ-GT/AST ratio may be better than PIVKA-II and AFP in the diagnosis of early-stage HBV-related HCC, and its combination with PIVKA-II and AFP can improve the diagnostic value for HBV-related HCC.
View article: Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition
Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition Open
Our findings demonstrate that CSCs characterized by elevated mitochondrial ROS level potentiate cancer metastasis. Mechanistically, elevated mitochondrial ROS via fatty acid β-oxidation, activates the MAPK cascades, resulting in the epithe…
View article: Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA
Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA Open
The serological detection of antibodies to Treponema pallidum is essential to the diagnosis of syphilis. However, for the presence of cross-reaction, the specific antibody tests [e.g., enzyme-linked immunosorbent assay (ELISA)] always have…
View article: Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA v1
Urea-mediated dissociation alleviate the false-positive Treponema pallidum-specific antibodies detected by ELISA v1 Open
The serological detection of antibodies to Treponema pallidum is essential to the diagnosis of syphilis. However, for the presence of cross-reaction, the specific antibody tests [e.g., enzyme-linked immunosorbent assay (ELISA)] always have…
View article: Landscape renewal of urban public space under the concept of sustainable development: a case study of Guilin city
Landscape renewal of urban public space under the concept of sustainable development: a case study of Guilin city Open
With the theory of “sustainable development” as the theoretical support, the public space landscape of Guilin City is taken as the research object, and from the perspective of landscape architecture, the public space landscape and the non-…
View article: Study on Application of Native Plants in Park Greening in Guilin
Study on Application of Native Plants in Park Greening in Guilin Open
With the Guangxi Guilin being listed as an innovative demonstration zone for the national sustainable development agenda in 2018, the urban construction processes in Guilin continued to advance. In the construction of city image, garden pl…