Qingqing Wei
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View article: NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma Open
Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in China, often diagnosed at advanced stages. The 5-methylcytosine (m5C) RNA modification plays a crucial role in tumorigenesis, influencing cell proliferation, different…
View article: TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis
TRIM25 degrades BRD7 protein stability through the ubiquitin proteasome pathway to promote breast cancer progression and paclitaxel resistance by activating YB1/Bcl-2 transcription axis Open
Paclitaxel (PTX) is one of the most common chemotherapeutic drugs for treating breast cancer (BC), but resistance to PTX chemotherapy remains the major cause of treatment failure in BC patients. Our previous studies demonstrated that BRD7 …
View article: Editorial: Epigenetic regulation in fibrosis
Editorial: Epigenetic regulation in fibrosis Open
View article: Integrated Single-Cell Analysis Reveals the Heterogeneity of Tumor-Associated Macrophages and Their Implications for Immunotherapy in Colorectal Cancer
Integrated Single-Cell Analysis Reveals the Heterogeneity of Tumor-Associated Macrophages and Their Implications for Immunotherapy in Colorectal Cancer Open
This single-cell study established an accurate classification system of CRC TAMs, unveiling their diverse roles in modulating tumor biology and assisting in treatment options of CRC patients.
View article: X-linked lymphoproliferative disease type 1: a clinical and genetic update
X-linked lymphoproliferative disease type 1: a clinical and genetic update Open
X-linked lymphoproliferative disease (XLP), also known as Duncan’s disease, is a primary immunodeficiency disorder linked to the X chromosome. In 1998, SH2D1A, which encodes the signaling lymphocyte activation molecule (SLAM)-associated pr…
View article: Nanomaterials in petroleum engineering: Progress, current applications and emerging challenges
Nanomaterials in petroleum engineering: Progress, current applications and emerging challenges Open
The petroleum industry faces mounting challenges in exploring, extracting, and processing hydrocarbon resources as conventional reserves become depleted and operations move toward more technically demanding environments. This review examin…
View article: New Targets for Treating Cancer: Copper Death and Copper Accumulation in Cancer Cells
New Targets for Treating Cancer: Copper Death and Copper Accumulation in Cancer Cells Open
The accumulation of copper ions plays an important role in the apoptosis of cancer cells. Definition of copper death: Copper death (Cuproptosis) is a new form of programmed cell death caused by excessive copper. Copper ions can participate…
View article: Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance
Autophagy: a critical mechanism of N6-methyladenosine modification involved in tumor progression and therapy resistance Open
View article: C1-FDX is required for the assembly of mitochondrial complex I and subcomplexes of complex V in Arabidopsis
C1-FDX is required for the assembly of mitochondrial complex I and subcomplexes of complex V in Arabidopsis Open
C1-FDX (Complex I-ferredoxin) has been defined as a component of CI in a ferredoxin bridge in Arabidopsis mitochondria. However, its full function remains to be addressed. We created two c1-fdx mutants in Arabidopsis using the CRISPR-Cas9 …
View article: Honokiol inhibits arsenic trioxide-induced cardiomyopathy by modulating ferroptosis via SIRT3 signaling pathway
Honokiol inhibits arsenic trioxide-induced cardiomyopathy by modulating ferroptosis via SIRT3 signaling pathway Open
Background Our previous studies have confirmed that Honokiol exerts protective effect on cardiomyocytes and cardiac tissue against ATO-induced cardiotoxicity, which is attributed to inhibiting cardiomyocyte apoptosis via reduced oxidative …
View article: HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo
HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo Open
Autophagy has been reported to participate in renal fibrosis, but its role and underlying activation mechanism is unclear. In this study, we report the role of HIF-1 in autophagy activation in models of renal fibrosis and further investiga…
View article: The metabolic pathway regulation in kidney injury and repair
The metabolic pathway regulation in kidney injury and repair Open
Kidney injury and repair are accompanied by significant disruptions in metabolic pathways, leading to renal cell dysfunction and further contributing to the progression of renal pathology. This review outlines the complex involvement of va…
View article: Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer Open
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs also contribute to tumor progression and resistance to immune checkpoint blockade (ICB). Targeting MPs could be an effective strategy to enhance ICB effic…
View article: Efficacy and safety of baricitinib for the treatment of hospitalized adults with COVID-19: a systematic review and meta-analysis
Efficacy and safety of baricitinib for the treatment of hospitalized adults with COVID-19: a systematic review and meta-analysis Open
View article: Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Myeloid PFKFB3-mediated glycolysis promotes kidney fibrosis Open
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, p…
View article: Spatial and Temporal Evolutionary Characteristics of Landscape Pattern of a Typical Karst Watershed Based on GEE Platform
Spatial and Temporal Evolutionary Characteristics of Landscape Pattern of a Typical Karst Watershed Based on GEE Platform Open
Given the high degree of fragmentation and poor resistance to disturbance in karst landscapes, it is important to clarify the spatial and temporal dynamics of landscape patterns in karst areas when designing karst ecological protection str…
View article: PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis
PFKFB3-Mediated Glycolysis Boosts Fibroblast Activation and Subsequent Kidney Fibrosis Open
Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofruc…
View article: Two tripartite classification systems of CD86+ and CD206+ macrophages are significantly associated with tumor recurrence in stage II-III colorectal cancer
Two tripartite classification systems of CD86+ and CD206+ macrophages are significantly associated with tumor recurrence in stage II-III colorectal cancer Open
Introduction The prognostic value of tumor-associated macrophages remains unclear in colorectal cancer (CRC). Two tripartite classification systems, namely, ratio and quantity subgroups, were investigated as the prognostic stratification t…
View article: Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis
Hypermethylation suppresses microRNA-219a-2 to activate the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis Open
Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in renal fibrosis. Here, we report the regulation of microRNA-219a-2 (mir-219a-2) by DNA methylation in fibrotic kidneys, unveiling the crosstalk between…
View article: PHB3 Is Required for the Assembly and Activity of Mitochondrial ATP Synthase in Arabidopsis
PHB3 Is Required for the Assembly and Activity of Mitochondrial ATP Synthase in Arabidopsis Open
Mitochondrial ATP synthase is a multiprotein complex, which consists of a matrix-localized F1 domain (F1-ATPase) and an inner membrane-embedded Fo domain (Fo-ATPase). The assembly process of mitochondrial ATP synthase is complex and requir…
View article: Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19: a systematic review and meta-analysis
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19: a systematic review and meta-analysis Open
Several clinical trials have evaluated the efficacy and safety of baricitinib in COVID-19 patients. Recently, there have been reports on critical patients, which are different from previous research results. Studies were searched in PubMed…
View article: High Infiltration of CD203c+ Mast Cells Reflects Immunosuppression and Hinders Prognostic Benefit in Stage II-III Colorectal Cancer
High Infiltration of CD203c+ Mast Cells Reflects Immunosuppression and Hinders Prognostic Benefit in Stage II-III Colorectal Cancer Open
High AMC infiltration is associated with worse survival outcomes in stages II-III CRC. AMC density may serve as a potential biomarker for survival benefit in patients receiving adjuvant chemotherapy. This AMC-based nomogram could provide b…
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Contents Open
View article: Deciphering the vital roles and mechanism of m5C modification on RNA in cancers.
Deciphering the vital roles and mechanism of m5C modification on RNA in cancers. Open
5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect o…
View article: Extravasation of Blood and Blood Toxicity Drives Tubular Injury from RBC Trapping in Ischemic AKI
Extravasation of Blood and Blood Toxicity Drives Tubular Injury from RBC Trapping in Ischemic AKI Open
Red blood cell (RBC) trapping is common in ischemic acute kidney injury (AKI) and presents as densely packed RBCs that accumulate within and engorge the kidney medullary circulation. In this study, we tested the hypothesis that “RBC trappi…
View article: Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery
Aspirin versus LMWH for VTE prophylaxis after orthopedic surgery Open
Low molecular weight heparin (LMWH) is often used to prevent perioperative venous thrombosis after surgery, but aspirin is also recommended by academics. Studies were searched in electronic databases until February 24, 2023. We performed a…
View article: SA82 A Bayesian Network Meta-Analysis of the Tyrosine Kinase Inhibitors (TKI) for ALK-Positive Advanced Non-Small Cell Lung Cancer With or Without Brain Metastasis
SA82 A Bayesian Network Meta-Analysis of the Tyrosine Kinase Inhibitors (TKI) for ALK-Positive Advanced Non-Small Cell Lung Cancer With or Without Brain Metastasis Open
View article: PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4
PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4 Open
View article: ASK1 Inhibitor in Chronic Kidney Disease Therapy: From Bench to Bedside
ASK1 Inhibitor in Chronic Kidney Disease Therapy: From Bench to Bedside Open
View article: Susceptibility of renal fibrosis in diabetes: Role of hypoxia inducible factor‐1
Susceptibility of renal fibrosis in diabetes: Role of hypoxia inducible factor‐1 Open
Diabetes may prevent kidney repair and sensitize the kidney to fibrosis or scar formation. To test this possibility, we examined renal fibrosis induced by unilateral ureteral obstruction (UUO) in diabetic mouse models. Indeed, UUO induced …