Qiang Du
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View article: Effect of Thiamine Supplementation on Mortality in Septic Patients: A Meta-Analysis of Randomized Controlled Trials
Effect of Thiamine Supplementation on Mortality in Septic Patients: A Meta-Analysis of Randomized Controlled Trials Open
Background Sepsis is a life-threatening condition characterized by a dysregulated host response to infection and leads to high mortality rates. Thiamine has been proposed as a potential therapeutic agent in sepsis. However, the effect of t…
View article: COVID-19 infection was associated with poor sperm quality: a cross-sectional and longitudinal clinical observation study
COVID-19 infection was associated with poor sperm quality: a cross-sectional and longitudinal clinical observation study Open
To ascertain whether COVID-19 infection affects sperm quality and measure the scale of the effects. A cross sectional study and a longitudinal study were conducted during the SARS-CoV-2 pandemic (from September 7th 2022 to late January 202…
View article: The effect of cigarette smoking on the serum levels of calcium and 25 hydroxy vitamin D in patients with postmenopausal osteoporosis
The effect of cigarette smoking on the serum levels of calcium and 25 hydroxy vitamin D in patients with postmenopausal osteoporosis Open
Objectives Deficiency of calcium and vitamin D is a common finding in postmenopausal osteoporosis (PMOP). However, the effect of cigarette smoking on the serum levels of calcium and 25-hydroxyvitamin D [25(OH)D] remains inconclusive. Metho…
View article: Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells
Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells Open
This study aims to investigate the effect of angiopoietin like 8 (ANGPTL8) on gestational diabetes mellitus (GDM) and insulin resistance (IR). The GDM model was induced by high fat diet in mice, and IR was observed. The expression and secr…
View article: Construction and Validation of Novel Nomograms for Predicting Prognosis of Pancreatic Ductal Adenocarcinoma After Surgery According to Different Primary Cancer Locations
Construction and Validation of Novel Nomograms for Predicting Prognosis of Pancreatic Ductal Adenocarcinoma After Surgery According to Different Primary Cancer Locations Open
Background/Aims Pancreatic ductal adenocarcinoma (PDAC) can occur in different parts of the pancreas. This study aimed to identify clinicopathological characteristics independently correlated with the prognosis of PDAC of the pancreatic he…
View article: Gender and Socioeconomic Disparities in Global Burden of Epilepsy: An Analysis of Time Trends From 1990 to 2017
Gender and Socioeconomic Disparities in Global Burden of Epilepsy: An Analysis of Time Trends From 1990 to 2017 Open
Objective: The objective of the study is to investigate the gender and socioeconomic disparities in the global burden of epilepsy by prevalence and disability-adjusted life-years (DALYs). Methods: The global, regional, and national gender-…
View article: Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study
Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study Open
National Natural Science Foundation of China and Guangzhou Science and Technology Project.
View article: <p>CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway</p>
CD276 Promotes Vasculogenic Mimicry Formation in Hepatocellular Carcinoma via the PI3K/AKT/MMPs Pathway Open
CD276 may promote VM formation by activating the PI3K/AKT/MMPs pathway and inducing the EMT process in HCC. CD276 may serve as a promising candidate for the anti-VM treatment of HCC.
View article: Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice
Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice Open
Hypothalamic astrocytes are important contributors that activate gonadotropin-releasing hormone (GnRH) neurons and promote GnRH/LH (luteinizing hormone) surge. However, the potential roles and mechanisms of astrocytes during the early repr…
View article: Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer
Receptor‑interacting serine/threonine‑protein kinase 1 promotes the progress and lymph metastasis of gallbladder cancer Open
Receptor‑interacting serine/threonine‑protein kinase 1 (RIP‑1) is highly expressed in gallbladder cancer, and is very important in promoting tumor proliferation and invasion. The underlying mechanism in this promotion is the RIP‑1‑nuclear …
View article: Expression and prognostic value of soluble CD97 and its ligand CD55 in intrahepatic cholangiocarcinoma
Expression and prognostic value of soluble CD97 and its ligand CD55 in intrahepatic cholangiocarcinoma Open
The incidence rate of intrahepatic cholangiocarcinoma is rising, and treatment options are limited. Therefore, new biological markers of intrahepatic cholangiocarcinoma are needed. Immunohistochemistry and enzyme-linked immunosorbent assay…
View article: Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins
Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins Open
As a highly conserved metabolic pathway, the Wnt signaling pathway is involved in cell differentiation, proliferation and several other processes. In normal cells, this pathway is suppressed, and abnormal activation is often associated wit…
View article: TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway
TNF-alpha promotes lymphangiogenesis and lymphatic metastasis of gallbladder cancer through the ERK1/2/AP-1/VEGF-D pathway Open
Taken together, our data suggest that TNF-α can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1/VEGF-D pathway.
View article: Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal-regulated kinase 1/2 signaling pathway
Chrysin inhibits human airway smooth muscle cells proliferation through the extracellular signal-regulated kinase 1/2 signaling pathway Open
Asthma is a chronic airway inflammatory disease characterized by an increased mass of airway smooth muscle (ASM). Chrysin (5,7-dihydroxyflavone), a natural flavonoid, has been shown to exert multiple biological activities, including anti-i…
View article: Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma
Serum vascular endothelial growth factors C and D as forecast tools for patients with gallbladder carcinoma Open
Gallbladder carcinoma (GBC) is the most common cancer of the biliary tract. Lymph node metastasis (LNM) is the major diffusion route of GBC and is a prognosis factor. The aim of study was to assess the potential of the serum VEGF-C and VEG…