Qingyu Yao
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View article: An engineering-reinforced hypoxia-preconditioned exosome-integrated hydrogel delays intervertebral disc degeneration via the PPARγ-autophagy axis
An engineering-reinforced hypoxia-preconditioned exosome-integrated hydrogel delays intervertebral disc degeneration via the PPARγ-autophagy axis Open
The local delivery of exosomes (Exo) through hydrogels is considered an effective method for treating intervertebral disc degeneration (IVDD). Based on the limitations of the hypoxic microenvironment in intervertebral disc (IVD), this stud…
View article: Clinical features and management of postoperative lumbar intervertebral space infections following spinal endoscopy: a retrospective analysis
Clinical features and management of postoperative lumbar intervertebral space infections following spinal endoscopy: a retrospective analysis Open
Background Postoperative lumbar intervertebral space infections following spinal endoscopy are infrequent but severe complications that can markedly affect patient recovery and treatment outcomes. Early diagnosis remains challenging due to…
View article: Comparison of Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo‐<scp>ULBD</scp>) and Posterior Lumbar Interbody Fusion (<scp>PLIF</scp>) in Managing Multi‐Segmental Lumbar Spinal Stenosis: Technique and Early Outcomes
Comparison of Endoscopic Unilateral Laminectomy for Bilateral Decompression (Endo‐<span>ULBD</span>) and Posterior Lumbar Interbody Fusion (<span>PLIF</span>) in Managing Multi‐Segmental Lumbar Spinal Stenosis: Technique and Early Outcomes Open
Objectives Lumbar spinal stenosis is a common degenerative spine condition that leads to severe pain and disability. Surgical intervention is often required when conservative treatments fail, but the choice between different surgical techn…
View article: Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia Open
These findings underscored the significance of cilia on ependymal cells and the evolving microenvironment post-syringomyelia, providing valuable insights for clinical treatment strategies for this condition.
View article: In-Human Assessment of Radio Frequency Induced Heating for Implants during MRI
In-Human Assessment of Radio Frequency Induced Heating for Implants during MRI Open
Radio frequency induced heating of medical implants during magnetic resonance imaging (MRI) poses a serious threat to patient safety, and in vivo assessment of heating permits individualized on-site safety assessment. Based on the proton r…
View article: Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis
Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis Open
Peripheral nerve stimulation is an effective neuromodulation method in patients with lower extremity movement disorders caused by stroke, spinal cord injury, or other diseases. However, most current studies on rehabilitation using sciatic …
View article: The Natural History of Chiari Malformation-Syringomyelia: Evidence of Bidirectional Flow of Central Canal Fluid within the Spinal Cord
The Natural History of Chiari Malformation-Syringomyelia: Evidence of Bidirectional Flow of Central Canal Fluid within the Spinal Cord Open
View article: Population <scp>PK</scp>/<scp>PD</scp> model of tacrolimus for exploring the relationship between accumulated exposure and quantitative scores in myasthenia gravis patients
Population <span>PK</span>/<span>PD</span> model of tacrolimus for exploring the relationship between accumulated exposure and quantitative scores in myasthenia gravis patients Open
Tacrolimus is an important immunosuppressant used in the treatment of myasthenia gravis (MG). However, the population pharmacokinetic (PK) characteristics together with the exposure‐response of tacrolimus in the treatment of MG remain larg…
View article: Identification of two tandem genes associated with primary rosette branching in flowering Chinese cabbage
Identification of two tandem genes associated with primary rosette branching in flowering Chinese cabbage Open
Branching is an important agronomic trait determining plant architecture and yield; however, the molecular mechanisms underlying branching in the stalk vegetable, flowering Chinese cabbage, remain unclear. The present study identified two …
View article: Neurological deterioration after posterior fossa decompression for adult syringomyelia: Proposal for a summarized treatment algorithm
Neurological deterioration after posterior fossa decompression for adult syringomyelia: Proposal for a summarized treatment algorithm Open
Background Patients with syringomyelia who present with new neurological symptoms after posterior fossa decompression (PFD) are not uncommon. However, systematic reports on different pathologies are few in the literature. Objective The pur…
View article: An integrated PK/PD model investigating the impact of tumor size and systemic safety on animal survival in SW1990 pancreatic cancer xenograft
An integrated PK/PD model investigating the impact of tumor size and systemic safety on animal survival in SW1990 pancreatic cancer xenograft Open
View article: Spinal Obstruction-Related vs. Craniocervical Junction-Related Syringomyelia: A Comparative Study
Spinal Obstruction-Related vs. Craniocervical Junction-Related Syringomyelia: A Comparative Study Open
Background No prior reports have focused on spinal cord injury (SCI) characteristics or inflammation after destruction of the blood–spinal cord barrier by syringomyelia. This study aimed to determine the differences in syringomyelia-relate…
View article: Longitudinal and time‐to‐event modeling for prognostic implications of radical surgery in retroperitoneal sarcoma
Longitudinal and time‐to‐event modeling for prognostic implications of radical surgery in retroperitoneal sarcoma Open
Retroperitoneal sarcoma (RPS) is a rare malignancy which can be difficult to manage due to the variety of clinical behaviors. In this study, we aimed to develop a parametric modeling framework to quantify the relationship between postopera…
View article: SPECT Imaging of Acute Disc Herniation by Targeting Integrin α5β1 in Rat Models
SPECT Imaging of Acute Disc Herniation by Targeting Integrin α5β1 in Rat Models Open
Objective Traditional morphological imaging of intervertebral disc herniation (IVDH) is challenging in early disease diagnosis. Aiming at the early diagnosis of IVD by non-invasive molecular imaging targeting of integrin α5β1, we performed…
View article: Oblique Lumbar Interbody Fusion Using a Stand-Alone Construct for the Treatment of Adjacent-Segment Lumbar Degenerative Disease
Oblique Lumbar Interbody Fusion Using a Stand-Alone Construct for the Treatment of Adjacent-Segment Lumbar Degenerative Disease Open
Objective Adjacent-segment disease (ASD) is common in patients undergone previous lumbar fusion. A typical revision treatment from posterior approach requires management of postoperative scar tissue and previously implanted instrumentation…
View article: Spinal obstruction-related versus craniocervical junction related syringomyelia: a comparative study of spinal cord injury
Spinal obstruction-related versus craniocervical junction related syringomyelia: a comparative study of spinal cord injury Open
Background No prior reports have focused on spinal cord injury (SCI) characteristics or inflammation after destruction of the blood-spinal cord barrier by syringomyelia. To compare the difference of syringomyelia-related central SCI betwee…
View article: Prognostic factors and nomogram prediction of survival probability in primary spinal cord astrocytoma patients
Prognostic factors and nomogram prediction of survival probability in primary spinal cord astrocytoma patients Open
OBJECTIVE Knowledge on the management of spinal cord astrocytoma (SCA) remains scarce. Here, the authors constructed and validated a predictive nomogram, often used for individualized prognosis and evaluations, to estimate cancer-specific …
View article: Correction to: A novel classification and its clinical significance in Chiari I malformation with syringomyelia based on high‑resolution MRI
Correction to: A novel classification and its clinical significance in Chiari I malformation with syringomyelia based on high‑resolution MRI Open
View article: Wireless Epidural Electrical Stimulation in Combination With Serotonin Agonists Improves Intraspinal Metabolism in Spinal Cord Injury Rats
Wireless Epidural Electrical Stimulation in Combination With Serotonin Agonists Improves Intraspinal Metabolism in Spinal Cord Injury Rats Open
View article: Markerless Rat Behavior Quantification With Cascade Neural Network
Markerless Rat Behavior Quantification With Cascade Neural Network Open
Quantifying rat behavior through video surveillance is crucial for medicine, neuroscience, and other fields. In this paper, we focus on the challenging problem of estimating landmark points, such as the rat's eyes and joints, only with ima…
View article: Quantitative Reduction of Basilar Invagination With Atlantoaxial Dislocation by a Posterior Approach
Quantitative Reduction of Basilar Invagination With Atlantoaxial Dislocation by a Posterior Approach Open
Quantitative posterior reduction by individualized cage and adjusting ΔPOCA is feasible for treating BI with AAD.
View article: Chronic extradural compression of spinal cord leads to syringomyelia in rat model
Chronic extradural compression of spinal cord leads to syringomyelia in rat model Open
Background Syringomyelia is a common spinal cord lesion. However, whether CSF blockage is linked to the formation and enlargement of syringomyelia is still controversial. The current model of syringomyelia needs modification to more closel…
View article: Preclinical PK/PD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer
Preclinical PK/PD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer Open
View article: Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia
Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia Open
Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one of the most devastating complications of gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective actions in vario…
View article: Identification of RFC5 as a novel potential prognostic biomarker in lung cancer through bioinformatics analysis
Identification of RFC5 as a novel potential prognostic biomarker in lung cancer through bioinformatics analysis Open
Lung cancer is the leading cause of mortalities among all types of cancer. Therefore, the screening of biomarkers that are related with the progression of lung cancer is crucial for early diagnosis and efficient therapy of lung cancer. In …
View article: Time-dependent pharmacokinetics of dexamethasone and its efficacy in human breast cancer xenograft mice: a semi-mechanism-based pharmacokinetic/pharmacodynamic model
Time-dependent pharmacokinetics of dexamethasone and its efficacy in human breast cancer xenograft mice: a semi-mechanism-based pharmacokinetic/pharmacodynamic model Open
View article: Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer
Dopamine D2 receptor antagonist sulpiride enhances dexamethasone responses in the treatment of drug-resistant and metastatic breast cancer Open
View article: Low-dose bevacizumab induces radiographic regression of vestibular schwannomas in neurofibromatosis type 2: A case report and literature review
Low-dose bevacizumab induces radiographic regression of vestibular schwannomas in neurofibromatosis type 2: A case report and literature review Open
The current case study aimed to explore the efficacy of a low-dose bevacizumab regimen in inhibiting tumor growth and minimizing adverse effects. A 55-year-old man with neurofibromatosis type 2 (NF2) suffered bilateral vestibular schwannom…