Qingzhen Liu
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View article: Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P
Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P Open
Conclusion: HIF-2α ameliorated lipid metabolism disorders and podocyte damage in DKD by downregulating S1P, providing a novel insight for HIF-2α against DKD.
View article: Effects and Mechanisms of Paeoniflorin in Relieving Neuropathic Pain: Network Pharmacological Analysis and Experimental Validation
Effects and Mechanisms of Paeoniflorin in Relieving Neuropathic Pain: Network Pharmacological Analysis and Experimental Validation Open
Neuropathic pain (NP) is a prevalent condition that can lead to a variety of complications, significantly impacting patients' quality of life. Previous studies have confirmed that paeoniflorin (PF) demonstrates both therapeutic pain relief…
View article: Astrocytic N-myc downstream-regulated gene 2 is involved in neural injury induced by sepsis-associated encephalopathy
Astrocytic N-myc downstream-regulated gene 2 is involved in neural injury induced by sepsis-associated encephalopathy Open
SAE is a systemic inflammatory response syndrome resulting from severe infection, which can progress to multiorgan dysfunction and mortality. Astrocytic-specific NDRG2, a stress response gene, has been implicated in regulating astrocyte re…
View article: Therapeutic Hypothermia Increases the Expression of RNA-binding Protein Motif 3 and Attenuates Cognitive Deficits Following Cardiac Arrest in Rats
Therapeutic Hypothermia Increases the Expression of RNA-binding Protein Motif 3 and Attenuates Cognitive Deficits Following Cardiac Arrest in Rats Open
View article: Increasing the dose of recombinant human thrombopoietin can enhance platelet engraftment after allogeneic haematopoietic stem cell transplantation: A <scp>NICHE</scp> cohort study
Increasing the dose of recombinant human thrombopoietin can enhance platelet engraftment after allogeneic haematopoietic stem cell transplantation: A <span>NICHE</span> cohort study Open
View article: Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the <scp>TXNIP</scp>/<scp>NLRP3</scp>/<scp>IL</scp>‐1β Signaling Pathway
Epigallocatechin‐3‐Gallate Ameliorates Diabetic Kidney Disease by Inhibiting the <span>TXNIP</span>/<span>NLRP3</span>/<span>IL</span>‐1β Signaling Pathway Open
Recent research indicates that the activation of the NLRP3 inflammasome is crucial in the development of diabetic kidney disease (DKD). Epigallocatechin‐3‐gallate (EGCG), the predominant catechin in green tea, has been noted for its anti‐i…
View article: The antagonistic activity of Streptomyces spiroverticillatus (No. HS1) against of poplar canker pathogen Botryosphaeria dothidea
The antagonistic activity of Streptomyces spiroverticillatus (No. HS1) against of poplar canker pathogen Botryosphaeria dothidea Open
View article: Short-term effect of low-dose roxadustat combined with erythropoiesis-stimulating agent treatment for erythropoietin-resistant anemia in patients undergoing maintenance hemodialysis
Short-term effect of low-dose roxadustat combined with erythropoiesis-stimulating agent treatment for erythropoietin-resistant anemia in patients undergoing maintenance hemodialysis Open
Background Erythropoietin resistance is present in some patients with chronic kidney disease, especially in those undergoing hemodialysis, and is often treated using roxadustat rather than iron supplements and erythropoiesis-stimulating ag…
View article: FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease
FN1 and TGFBI are key biomarkers of macrophage immune injury in diabetic kidney disease Open
The pathogenesis of diabetic kidney disease (DKD) is complex, and the existing treatment methods cannot control disease progression well. Macrophages play an important role in the development of DKD. This study aimed to search for biomarke…
View article: The antagonistic activity of Streptomyces scopuliridis (No. HS1) against of poplar canker pathogen Botryosphaeria dothidea
The antagonistic activity of Streptomyces scopuliridis (No. HS1) against of poplar canker pathogen Botryosphaeria dothidea Open
Background Poplar canker caused by Botryosphaeria dothidea is one of the most severe plant disease that is also associated with death of poplars worldwide. In this study, the biocontrol efficacy and mechanisms of action of Streptomyces sco…
View article: Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients
Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients Open
Necroptosis is a programmed form of necrotic cell death that serves as a host gatekeeper for defense against invasion by certain pathogens. Previous studies have uncovered the essential role of necroptosis in tumor progression and implied …
View article: Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice
Antidepressant effects of repeated s-ketamine administration as NMDAR Antagonist: Involvement of CaMKIIα and mTOR signaling in the hippocampus of CUMS mice Open
With the approval of s-ketamine nasal spray as a novel antidepressant, its robust antidepressant effects have been intensively examined in clinical trials. However, the therapeutic efficacy and mechanisms of repeated intermittent drug admi…
View article: Effects of exposure to the inhalational anaesthetic sevoflurane on the male reproductive system in rats
Effects of exposure to the inhalational anaesthetic sevoflurane on the male reproductive system in rats Open
Objectives The purpose of this study was to explore the effects of inhalational anaesthetics on the male reproductive system in neonatal rats. Methods Postnatal day 6 (P6) male rat pups were assigned to 2 groups of 40 rats each. The contro…
View article: Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder—Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder—Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity Open
Posttraumatic stress disorder (PTSD) is a persistent and severe psychological and mental disorder resulting from experiences of serious trauma or stress and is suffered by many individuals. Previous studies have shown that pretreatment wit…
View article: Study of 60 Adult Patients to Compare Standard Postoperative Clinical Assessment with Train-of-Four Ratio ≥0.9 on Patient Outcomes Using Postoperative Spirometry and Neuromuscular Function Measurements Following Extubation
Study of 60 Adult Patients to Compare Standard Postoperative Clinical Assessment with Train-of-Four Ratio ≥0.9 on Patient Outcomes Using Postoperative Spirometry and Neuromuscular Function Measurements Following Extubation Open
BACKGROUND Postoperative tracheal extubation requires optimal timing to ensure patient safety and normal muscle function. The train-of-four ratio (TOFR) of the fourth muscle response compared with the first indicates a non-depolarizing neu…
View article: Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report
Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report Open
In the context of the current Omicron epidemic and high vaccination rate in the population, it is feasible to receive PB-HSC from infected donors even for immunocompromised patients. This also provides some references for our later donor s…
View article: Hematopoietic Stem Cell Transplantation from an Infected Sars-Cov2haploidentical Donor: A Case Report
Hematopoietic Stem Cell Transplantation from an Infected Sars-Cov2haploidentical Donor: A Case Report Open
View article: Autophagy: A New Mechanism for Esketamine as a Depression Therapeutic
Autophagy: A New Mechanism for Esketamine as a Depression Therapeutic Open
Depression is a serious physical and mental disease, with major depressive disorder (MDD) being a hard-to-treat, life-threatening form of the condition. Currently, esketamine (ESK) is used in the clinical treatment of MDD, but the drug mec…
View article: Mesenchymal Stem Cells Modified with Angiotensin Converting Enzyme 2 are Superior in Ameliorating Inflammation and Oxidative Stress in Diabetic Nephropathy
Mesenchymal Stem Cells Modified with Angiotensin Converting Enzyme 2 are Superior in Ameliorating Inflammation and Oxidative Stress in Diabetic Nephropathy Open
Background The purpose of this study is to detect the effect of angiotensin converting enzyme 2 (ACE2)-modified mesenchymal stem cells (MSCs) on inflammation and oxidative stress in diabetic nephropathy (DN) and investigate the underlying …
View article: Systematic identification of autophagy-related proteins in Aedes albopictus
Systematic identification of autophagy-related proteins in Aedes albopictus Open
Autophagy is a conserved cellular process playing a role in maintenance of cellular homeostasis and response to changing nutrient conditions via degradation and recirculation of cellular redundant components. Autophagy-related proteins (At…
View article: Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats
Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats Open
Post-traumatic stress disorder (PTSD) is a mental disorder characterized by hippocampal neuron loss and cognitive dysfunction. The aim of the present study was to investigate the potential functional outcomes of transplantation of induced …
View article: PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity
PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity Open
BACKGROUND The pathogenesis of chemotherapy-induced neuropathy, a dose-dependent adverse effect of cisplatin, involves mitochondrial dysfunction. PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy removes damaged mitochondria…
View article: Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in <i>Aedes albopictus</i>
Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in <i>Aedes albopictus</i> Open
Aedes albopictus is a primary vector of hundreds of pathogens. Strong environmental adaptability and extensive global distribution of Aedes albopictus make it a severe threat to human health. Autophagy is a cellular process involved in mai…
View article: A hybrid FCW-EMD and KF-BA-SVM based model for short-term load forecasting
A hybrid FCW-EMD and KF-BA-SVM based model for short-term load forecasting Open
This paper proposes a hybrid short-term load forecasting method, which is based on the fuzzy combination weights as well as the empirical mode decomposition process (FCW-EMD), and support vector machine optimized via the Bat algorithm as w…
View article: Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus
Differences in the expression of long noncoding RNAs at different time points in the PTSD-like syndrome rat hippocampus Open
The aim of this study was to characterize the expression profiles at different time points in the PTSD-like syndrome rat hippocampus and perform analyses. PTSD rat models were made as reported by Rau, and we collected the hippocampus at di…
View article: Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility
Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility Open
Voltage-dependent anion channel (VDAC) is a multifunctional channel protein across the outer mitochondrial membrane of somatic cells and participates in many physiological and pathophysiological processes. Up to now, only a few studies, in…
View article: Effect of pioglitazone on neuropathic pain and spinal expression of TLR-4 and cytokines
Effect of pioglitazone on neuropathic pain and spinal expression of TLR-4 and cytokines Open
The molecular mechanisms underlying neuropathic pain have yet to be elucidated. The present study aimed to examine the modulation of neuroimmune activation in the spinal cord by the synthetic peroxisome proliferator-activated receptor gamm…
View article: siRNA-mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin-stimulated primary cultured microglia
siRNA-mediated silencing of phosphodiesterase 4B expression affects the production of cytokines in endotoxin-stimulated primary cultured microglia Open
Phosphodiesterase 4 (PDE4) has four subtypes: PDE4A, PDE4B, PDE4C and PDE4D. The expression of PDE4 subtypes in microglial cells and the specific contribution of each subtype to inflammation remain unclear. In this study, the expression of…
View article: Identification and isolation of kidney-derived stem cells from transgenic rats with diphtheria toxin-induced kidney damage
Identification and isolation of kidney-derived stem cells from transgenic rats with diphtheria toxin-induced kidney damage Open
Adult stem cells have been well characterized in numerous organs, with the exception of the kidneys. Therefore, the present study aimed to identify and isolate kidney-derived stem cells. A total of 12 Fischer 344 transgenic rats expressing…
View article: The Strica Homolog AaCASPS16 Is Involved in Apoptosis in the Yellow Fever Vector, Aedes albopictus
The Strica Homolog AaCASPS16 Is Involved in Apoptosis in the Yellow Fever Vector, Aedes albopictus Open
Caspases are a family of cysteine proteases playing essential roles during apoptosis. Seven caspases identified in Drosophila were Dronc, Dredd, Strica, Dcp-1, Decay, Drice and Damm. Among them, Strica is an insect-specific caspase contain…