Explanipedia

Geometric quantification of photonic 4D spin-orbit states Open

Liang Fang, Jinman Chen, Jia Cheng, Xiangbo Guo, Senlin Huang , et al. · 2025

High-dimensional photonic states have significantly advanced the fundamentals and applications of light. However, it remains huge challenges to quantify arbitrary states in high-dimensional Hilbert spaces with spin and orbital angular mome…

Engineered Intelligent Microenvironment Responsive Prodrug Conjugates Navigated by Bioinspired Lipoproteins for Reversing Liver Fibrosis Open

Mingzhu Fang, Boyu Su, Shilin Zhang, Fangxin Li, Yun Guo , et al. · 2025

Liver fibrosis (LF) is characterized by excessive production of reactive oxygen species (ROS), abnormal activation of hepatic stellate cells (HSCs), and subsequent extracellular matrix (ECM) deposition. The complexity of multiple interrela…

A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation Open

Boyu Su, Qinjun Chen, Xu‐Wen Li, Mingzhu Fang, Yu Wang , et al. · 2025

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tum…

Optical centroid orbiting metrology Open

Liang Fang, Jinman Chen, Qinjun Chen, Chujun Zhao · 2025

Optical interferometry has dramatically advanced the development of modern science and technology. Here we introduce an interesting centroid evolution phenomenon of orbital angular momentum (OAM) interference fields with broken rotational …

Two-dimensional Weyl nodal-line semimetal and antihelical edge states in a modified Kane-Mele model Open

Xiaokang Dai, Pei-Hao Fu, Yee Sin Ang, Qinjun Chen · 2024

The Kane-Mele model has been modified to achieve versatile topological\nphases. Previous work [Phys. Rev. Lett. 120, 156402 (2018)] introduced a\nstaggered intrinsic spin-orbit coupling effect to generate pseudohelical edge\nstates, with R…

Photocatalytic Degradation of Norfloxacin Antibiotics on ZnxCd(1-x)S/g-C3N4 Composites in Water Open

Zanen Wu, Qinjun Chen, Shibiao Wu · 2023

g-C₃N₄/Zn_xCd_(1-x)S composites were synthesized by a simple hydrothermal method. The composites were characterized by X-ray diffraction, UV-vis diffuse reflectance spectroscopy, infrared spectrosc…

Advanced nano-based strategies for mRNA tumor vaccine Open

Yangqi Qu, Jingjing Xu, Tong Zhang, Qinjun Chen, Tao Sun , et al. · 2023

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune responses. Along with the technological breakthroughs in genetic engineering and delivery sys…

Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation Open

Weiyi Xia, Chao Li, Qinjun Chen, Jiancheng Huang, Zhenhao Zhao , et al. · 2021

Macrophage‐Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke Open

Chao Li, Zhenhao Zhao, Yifan Luo, Tingting Ning, Peixin Liu , et al. · 2021

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective e…

A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy Open

Tao Sun, Guang‐Ping Zhang, Tingting Ning, Qinjun Chen, Yongchao Chu , et al. · 2021

A versatile tumor‐targeting stimuli‐responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal‐enhanced chemotherapy. A quenched photosensitizer (“off” state)…

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy Open

Qinjun Chen, Tao Sun, Chen Jiang · 2021

Isotropic or anisotropic screening in black phosphorous: can doping tip the balance? Open

Zhimin Liu, Ye Yang, Yueshao Zheng, Qinjun Chen, Yexin Feng · 2020

Black phosphorus (BP), a layered van der Waals (vdW) crystal, has unique in-plane band anisotropy and many resulting anisotropy properties such as the effective mass, electron mobility, optical absorption, thermal conductivity and plasmoni…

Penetrable Nanoplatform for “Cold” Tumor Immune Microenvironment Reeducation Open

Qinjun Chen, Yongqing He, Yu Wang, Chao Li, Yujie Zhang , et al. · 2020

Lack of tumor‐infiltration lymphocytes (TILs) and resistances by overexpressed immunosuppressive cells (principally, myeloid‐derived suppressor cells (MDSCs)) in tumor milieu are two major challenges hindering the effectiveness of immunoth…

Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer Open

Yu Zhou, Wenxi Zhou, Han Y. H. Chen, Qingbing Wang, Chao Li , et al. · 2019

Dandelion‐Like Tailorable Nanoparticles for Tumor Microenvironment Modulation Open

Qin Guo, Xi He, Chao Li, Yongqing He, Yiying Peng , et al. · 2019

Tumor‐associated macrophages (TAMs) constitute over 50% of the number of cells within the tumor, playing a major role in tumor progression and invasion. Remodeling the tumor immune microenvironment by modulating TAM polarization has been e…

Drug Delivery: Activated Platelets‐Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer (Adv. Funct. Mater. 13/2019) Open

Yujie Zhang, Xi Zhu, Han Y. H. Chen, Qinjun Chen, Wenxi Zhou , et al. · 2019

In article number 1806620, Chen Jiang and co-workers, inspired by the ability of activated platelets to track tumor metastasis, develop a novel activated plateletstargeting micelle for efficient anticancer drug delivery to primary and meta…

Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019) Open

Yifei Lü, Zhongyuan Guo, Yujie Zhang, Chao Li, Yu Zhang , et al. · 2019

An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co‐workers design a brain normalizing system to eliminate react…

Tumor Microenvironment‐Triggered Aggregated Magnetic Nanoparticles for Reinforced Image‐Guided Immunogenic Chemotherapy Open

Qinjun Chen, Lisha Liu, Yifei Lü, Han Y. H. Chen, Yujie Zhang , et al. · 2019

Anticancer therapies, which can induce cell death and elevate antitumor immune response in the meantime, are considered as effective treatments for many types of cancers. Immunogenic cell death (ICD) induced by chemodrugs is a promising an…

GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy Open

Qin Guo, Chao Li, Wenxi Zhou, Han Y. H. Chen, Yu Zhang , et al. · 2019

Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery o…

Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia Open

Yifei Lü, Zhongyuan Guo, Yujie Zhang, Chao Li, Yu Zhang , et al. · 2018

Current strategies for Alzheimer's disease (AD) treatments focus on pathologies in the late stage of the disease progression. Poor clinical outcomes are displayed due to the irreversible damages caused by early microglia abnormality which …

Dimeric Prodrug Self-Delivery Nanoparticles with Enhanced Drug Loading and Bioreduction Responsiveness for Targeted Cancer Therapy Open

Xi He, Kaimin Cai, Yu Zhang, Yifei Lü, Qin Guo , et al. · 2018

Efficient drug accumulation in tumor cells is essential for cancer therapy. Herein, we developed dimeric prodrug self-delivery nanoparticles (NPs) with enhanced drug loading and bioreduction responsiveness for triple negative breast cancer…

Sequentially Triggered Nanoparticles with Tumor Penetration and Intelligent Drug Release for Pancreatic Cancer Therapy Open

Xi He, Han Y. H. Chen, Lisha Liu, Yu Zhang, Yifei Lü , et al. · 2018

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive malignancy with a five year survival rate of <5%. The aberrant expression of extracellular matrix (ECM) in the tumor stroma forms a compact physical barrier, which that leads t…

Macrophage-Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy Open

Yu Zhang, Kaimin Cai, Chao Li, Qin Guo, Qinjun Chen , et al. · 2018

Various delivery vectors have been integrated within biologically derived membrane systems to extend their residential time and reduce their reticuloendothelial system (RES) clearance during systemic circulation. However, rational design i…

Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy Open

Xi He, Jinxiao Zhang, Chao Li, Yu Zhang, Yifei Lü , et al. · 2018

Efficient drug accumulation in tumor is essential for chemotherapy. We developed redox-responsive diselenide-based high-loading prodrug nanoparticles (NPs) for targeted triple negative breast cancer (TNBC) treatment. Method: Redox-r…

Platinum-Based Nanovectors Engineered with Immuno-Modulating Adjuvant for Inhibiting Tumor growth and Promoting Immunity Open

Lisha Liu, Qinjun Chen, Chunhui Ruan, Han Y. H. Chen, Yu Zhang , et al. · 2018

Although there is ample evidence that the chemotherapeutic drugs trigger an immune response, the efficient tumor rejection or regression is not guaranteed probably due to the massive immunosuppression within the tumor microenvironment. Thu…

Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma Open

Chunhui Ruan, Lisha Liu, Yifei Lü, Yu Zhang, Xi He , et al. · 2017

Photo-induced change of refractive index and transparency in Bi2Te3 films Open

Zengji Yue, Qinjun Chen, Amit Kumar Sahu, Xiaolin Wang, Miṅ Gu · 2017

We report on an 800 nm femtosecond laser beam induced giant refractive index modulation and enhancement of near-infrared transparency in topological insulator material Bi2Te3 thin films. An ultrahigh refractive index of up to 5.9 was obser…

Thermoelectric signals of state transition in polycrystalline SmB<sub>6</sub> Open

Zengji Yue, Qinjun Chen, Xiaolin Wang · 2016

Topological Kondo insulator SmB6 has attracted quite a lot of attention from the condensed matter physics community. A number of unique electronic properties, including low-temperature resistivity anomaly, 1D electronic transport and 2D Fe…

New insight into two-step near-infrared quantum cutting in Pr^3+ singly doped oxyfluoride glass-ceramics Open

Dechao Yu, Qinjun Chen, Hui Hong Lin, Y. Z. Wang, Qinyuan Zhang · 2015

Efficient near-infrared (NIR) quantum cutting (QC) in RE3+/Yb3+ requires the UV-blue photon excited RE3+ donor has intermediate energy level to separate the energy gaps (~10000 cm−1) resonant to Yb3+absorption. Thus the unique Pr3+/Yb3+ re…

Qinjun Chen YOU? Author Swipe