Explanipedia

Early detection of pulmonary aspiration during anesthetic induction via bedside electrical impedance tomography monitoring: A case report Open

Li Yang, Qionghua Lin, Zhanqi Zhao, Jun Zhang · 2025

Pulmonary aspiration (PA) of gastric contents, a rare but life-threatening complication during anesthesia, is frequently missed by traditional diagnostic methods relying on delayed symptoms or lung imaging. Here we present a novel applicat…

Supine transfer test-induced changes in cardiac index predict fluid responsiveness in patients without intra-abdominal hypertension Open

Zhiyong Zhao, Zhongwei Zhang, Jing Liu, Zhili Xia, Qian Xing , et al. · 2023

Background The reversible maneuver that mimics the fluid challenge is a widely used test for evaluating volume responsiveness. However, passive leg raising (PLR) does have certain limitations. The aim of the study is to determine whether t…

Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis Open

Pengmei Wang, Zhongwei Zhang, Shan Zhang, Qian Xing, Zhiyong Zhao , et al. · 2023

As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune checkpoint inhibitor-related pneumonitis (ICI-pneumonitis). The incidence of ICI-pneumonitis is …

Case Report: Treatment for steroid-refractory immune-related myocarditis with tofacitinib Open

Qian Xing, Zhongwei Zhang, Biao Zhu, Qionghua Lin, Lihua Shen , et al. · 2022

Introduction Immune therapy has ushered in a new era of tumor treatment, at the expense of immune-related adverse events, including rare but fatal adverse cardiovascular events, such as myocarditis. Steroids remain the cornerstone of thera…

Changes in the Cardiac Index Induced by Unilateral Passive Leg Raising in Spontaneously Breathing Patients: A Novel Way to Assess Fluid Responsiveness Open

Zhiyong Zhao, Zhongwei Zhang, Qionghua Lin, Lihua Shen, Pengmei Wang , et al. · 2022

Background Evaluation of fluid responsiveness in intensive care unit (ICU) patients is crucial. This study was to determine whether changes in the cardiac index (CI) induced by a unilateral passive leg raising (PLR) test in spontaneously b…

The diagnostic value of endoplasmic reticulum stress-related specific proteins GRP78 and CHOP in patients with sepsis: a diagnostic cohort study Open

Fangfang Li, Qionghua Lin, Lihua Shen, Zhongwei Zhang, Pengmei Wang , et al. · 2022

Compared with traditional inflammatory markers, ERS-related specific proteins GRP78 and CHOP have better sensitivity and specificity in the diagnosis of sepsis, which is helpful for clinicians in the diagnosis of sepsis.

Changes in Cardiac Index Induced by Unilateral Passive Leg Raising: a Novel Way for Assessing Fluid Responsiveness Open

Zhiyong Zhao, Zhongwei Zhang, Qionghua Lin, Lihua Shen, Pengmei Wang , et al. · 2021

Background: To evaluate the fluid responsiveness of patients, we examined the change in cardiac index (CI) during a unilateral passive leg raising (PLR) test using the ProAQT/Pulsioflex. In addition, we compared the change of CI triggered …

Myositis-myasthenia gravis overlap syndrome complicated with myasthenia crisis and myocarditis associated with anti-programmed cell death-1 (sintilimab) therapy for lung adenocarcinoma Open

Qian Xing, Zhongwei Zhang, Qionghua Lin, Lihua Shen, Pengmei Wang , et al. · 2020

Immune checkpoint inhibitors (ICIs) have improved clinical outcomes with a number of advanced malignancies. However, diverse immune-related adverse events (iRAEs) occurred with the widespread use of ICIs, some of which are rarely and life-…

A Prospective Multicenter Clinical Observational Study on Vancomycin Efficiency and Safety With Therapeutic Drug Monitoring Open

Xiaoyu Liang, Yaxing Fan, Minjie Yang, Jing Zhang, Jufang Wu , et al. · 2018

ChiCTR-OPC-16007920.

COL11A1 is overexpressed in recurrent non-small cell lung cancer and promotes cell proliferation, migration, invasion and drug resistance Open

Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Biao Zhu , et al. · 2016

Collagen type XI α1 (COL11A1), a minor fibrillar collagen, has been demonstrated to be involved in cell proliferation, migration and the tumorigenesis of many human malignancies. Previous studies have shown that COL11A1 may be a valuable d…

SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer Open

Lihua Shen, Min Yang, Qionghua Lin, Zhongwei Zhang, Changhong Miao , et al. · 2016

Currently, chemotherapy with platinum-based drugs including cisplatin is the most effective therapy for the treatment of non-small cell lung carcinoma (NSCLC). However, the efficacy of chemotherapy is limited due to commonly developed drug…

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