Explanipedia

Corrigendum to ‘Artificial intelligence-augmented ultrasound diagnosis of follicular-patterned thyroid neoplasms: a multicenter retrospective study’ [EClinicalMedicine Volume 86 (2025)/103351] Open

Hui Shen, Shufang Pei, Yue Huang, Chifa Zhang, Dan Yang , et al. · 2025

[This corrects the article DOI: 10.1016/j.eclinm.2025.103351.].

VSIG2 hinders gastric cancer progression by suppressing ANXA2-mediated NF-κB pathway activation Open

Qingfeng Ni, Yan Wang, Xinyue Bian, Qiuchan Qu, Bo Shen , et al. · 2025

As the fifth most common cancer and the third leading cause of cancer death worldwide, gastric cancer (GC) has long been a serious global health challenge. The purpose of this study was to explore the expression of V-set and immunoglobulin…

Irradiation-Induced Facile Synthesis and Characterization of Red Blood Cell-Like Polystyrene Particles Open

Wenhui Fan, Shuya Zhang, Qingfeng Ni, Yue Rong, Tianping Wang , et al. · 2025

This study developed a green γ-ray irradiation-assisted polymerization-self-assembly synergy strategy to fabricate red blood cell (RBC)-like morphology in an additive/template-free aqueous system at room temperature. By tuning the styrene/…

Noninvasive Deep Learning System for Preoperative Diagnosis of Follicular-Like Thyroid Neoplasms Using Ultrasound Images Open

Hui Shen, Yue Huang, Wenxiao Yan, Chifa Zhang, Ting Liang , et al. · 2025

Objective: To propose a deep learning (DL) system for the preoperative diagnosis of follicular-like thyroid neoplasms (FNs) using routine ultrasound images. Summary Background Data: Preoperative diagnosis of malignancy in nodules suspiciou…

Artificial intelligence-augmented ultrasound diagnosis of follicular-patterned thyroid neoplasms: a multicenter retrospective study Open

Hui Shen, Shufang Pei, Yue Huang, Suqing Wu, Chifa Zhang , et al. · 2025

UltraTwin: Towards Cardiac Anatomical Twin Generation from Multi-view 2D Ultrasound Open

Junxuan Yu, Yaofei Duan, Rongbo Ling, Wenqin Luo, Ang Zhang , et al. · 2025

Echocardiography is routine for cardiac examination. However, 2D ultrasound (US) struggles with accurate metric calculation and direct observation of 3D cardiac structures. Moreover, 3D US is limited by low resolution, small field of view …

Single-cell transcriptomic data reveal the cellular heterogeneity of glutamine metabolism in gastric premalignant lesions and early gastric cancer Open

Qingfeng Ni, Jiawei Yu, Yuanjie Niu, Zhenwei Han, Boyang Hu , et al. · 2025

Glutamine metabolism is a hallmark of cancer metabolism. This study aims to perform a comprehensive and systematic single-cell profile of glutamine metabolism in premalignant and malignant gastric lesions. We use single-cell transcriptomic…

Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6 Open

Weiwei Jiang, Liangliang Kong, Qingfeng Ni, Yeting Lu, Wenzhou Ding , et al. · 2023

[This corrects the article DOI: 10.1371/journal.pone.0101530.].

Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway Open

Qingfeng Ni, Hai Zhang, Xiaoli Shi, Xiangcheng Li · 2023

Comparison of nomogram with machine learning techniques for prediction of overall survival in patients with retroperitoneal liposarcoma Open

Peng Wang, Mingjie Xie, Xingchao Wang, Jiawei Yu, Erlin Chen , et al. · 2022

Background Retroperitoneal liposarcoma (RP-LPS) is a rare and overlooked tumor type. Because of the rarity and diversity RP-LPS histological subtypes, the diagnosis, treatment and prediction of survival, pose great challenges. This study c…

Exosomal microRNA-23a-3p contributes to the progression of cholangiocarcinoma by interaction with Dynamin3 Open

Qingfeng Ni, Hai Zhang, Xiaoli Shi, Xiangcheng Li · 2022

Cholangiocarcinoma (abbreviated as CCA) accounts for about 3% of digestive tract tumors, which is a rare disease with relatively low incidence. Herein, we firstly discovered overexpression of microRNA-23a-3p (abbreviated as miR-23a-3p) in …

Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis Open

Yan Zhang, Li Ding, Qingfeng Ni, Ran Tao, Jun Qin · 2021

Gastric cancer (GC) is one of the most common aggressive cancers. The discovery of an effective biomarker is necessary for GC diagnosis. In this study, we confirmed that Paired box gene 4 (PAX4) is up-regulated in GC tissues and cells via …

Protective effects of upregulated HO-1 gene against the apoptosis of human retinal pigment epithelial cells in vitro Open

Hong Yu, Yu-Ping Liang, Weiqi Chen, Liuxia You, Qingfeng Ni , et al. · 2021

AIM: To investigate the protective effect of heme oxygenase-1 (HO-1) against H2O2-induced apoptosis in human ARPE-19 cells. METHODS: The lentiviral vector expressing HO-1 was prepared and transfected into apoptotic ARPE-19 cells induced by…

MicroRNA-95-3p serves as a contributor to cisplatin resistance in human gastric cancer cells by targeting EMP1/PI3K/AKT signaling Open

Qingfeng Ni, Yan Zhang, Ran Tao, Xiaolong Li, Jianwei Zhu · 2021

MicroRNAs (miRNAs) are thought to be involved in the development of cisplatin (DDP) resistance in gastric cancer (GC). Using RNA sequencing analysis (RNA-seq), we found that miR-95-3p is associated with DDP resistance in GC. We discovered …

MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling Open

Zhouyang Cheng, Qingfeng Ni, Lei Qin, Yang Shi · 2021

Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a …

MiR-660-5p promotes the progression of hepatocellular carcinoma by interaction with YWHAH via PI3K/Akt signaling pathway Open

Yunyu Wu, Yan Zhang, Feng Wang, Qingfeng Ni, Mei Li · 2020

Currently, more and more studies show that aberrantly expressed microRNAs (miRNAs) are important driving factors for the pathogenesis of hepatocellular carcinoma (HCC). Based on the TCGA and GEO databases, miR-660-5p was identified as a po…

MicroRNA-92a promotes proliferation and invasiveness of gastric cancer cell by targeting FOXO1 gene Open

Jiawei Yu, Qingfeng Ni, Shu Zhang, Ruheng Hua, Ran Tao , et al. · 2020

The aim of this study is to investigate the effect of miRNA-92a on GC cell proliferation, migration and invasiveness, and the mechanism(s) involved. Four GC cell lines (SGC-7901, BGC-823, MKN45 and HGC-27) and normal human gastric epitheli…

miR‐92b promotes gastric cancer growth by activating the DAB2IP‐mediated PI3K/AKT signalling pathway Open

Qingfeng Ni, Yan Zhang, Jiawei Yu, Ruheng Hua, Quhui Wang , et al. · 2019

Objectives miR‐92b has been reported to play critical roles in several carcinomas; however, our understanding of the mechanisms by which miR‐92b stimulates gastric cancer (GC) is incomplete. The aim of this study was to investigate the cli…

Syndecan-2 in colorectal cancer plays oncogenic role via epithelial-mesenchymal transition and MAPK pathway Open

Ruheng Hua, Jiawei Yu, Xiyue Yan, Qingfeng Ni, Xiaofei Zhi , et al. · 2019

CDCA3 is a potential prognostic marker that promotes cell proliferation in gastric cancer Open

Yan Zhang, Wei Yin, Wei Cao, Peisheng Chen, Longjun Bian , et al. · 2019

Gastric cancer (GC) is an aggressive and highly lethal gastrointestinal cancer, with an exceedingly poor prognosis. In the present study, the carcinogenic mechanism of human GC and the role of cell division cycle‑associated 3 (CDCA3) were …

High expression of Nectin-4 is associated with unfavorable prognosis in gastric cancer Open

Yan Zhang, Jiaxuan Zhang, Qin Shen, Wei Hsian Yin, Hua Huang , et al. · 2018

Nectins are Ca²⁺-independent immunoglobulin-like cell adhesion molecules that belong to a family of four members that function in a number of biological cellular activities. Nectin-4 is overexpressed in several types of human ca…

Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis Open

Xiaofei Zhi, Baofei Jiang, Junbo Yu, Oluf Dimitri Røe, Jun Qin , et al. · 2016

The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival (DFS) and over…

MicroRNA-497 regulates cell proliferation in hepatocellular carcinoma Open

Wenzhou Ding, Qingfeng Ni, Yeting Lu, LIANG-LIANG KONG, Jianjun Yu , et al. · 2015

Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. MicroRNA-497 (miR-497) is known to be downregulated in several types of human cancer; however, the expression, function and underlying mechanisms of miR-497 in …

Cortactin promotes colon cancer progression by regulating ERK pathway Open

Qingfeng Ni, Jiawei Yu, Fei Qian, Naizhi Sun, Jianjia Xiao , et al. · 2015

Cortactin is upregulated in various cancers including breast cancer, head and neck squamous cell carcinoma and gastric cancer. However, the role of cortactin in the pathogenesis of colon cancer remains unclear. mRNA expression of cortactin…

Targeting MACC1 by RNA interference inhibits proliferation and invasion of bladder urothelial carcinoma in T24 cells. Open

Lin Xu, Xiang Ding, Qingfeng Ni, Shaoju Jin · 2015

The purpose of this article is to research on whether MACC1 can serve as a potential target for gene therapy of human bladder urothelial carcinoma (BUC). In this study, the expression of MACC1 gene was knocked down by RNA interference (RNA…

The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and their clinicopathological significance. Open

Lin Xu, Guojian Gu, Qingfeng Ni, Nan Li, Kangkang Yu , et al. · 2015

Overexpression of AEG-1 and Cyclin D1 are markedly correlated with TNM stage and recurrence of BUC. Cyclin D1 are markedly correlated with grade of BUC. Detection of AEG-1 and Cyclin D1 may be helpful to evaluate prognosis and infiltrative…

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