Explanipedia

Opportunities and challenges in synthetic biology for manufacture of bulk chemicals Open

Xiaolin Shen, Qipeng Yuan · 2025

The application of peripheral blood immune profiling in personalized treatment of locally advanced and advanced lung cancer: a nomogram approach Open

Tianwen Yin, Yikun Li, Sun Qixin, Qipeng Yuan, Shan Zhu , et al. · 2025

Purpose Immunotherapy has revolutionized the treatment of lung cancer, yet many patients experience limited or transient benefits. Identifying those most likely to benefit remains a critical challenge. This study aims to establish a predic…

Exploring deleterious non-synonymous SNPs in FUT2 gene, and implications for norovirus susceptibility and gut microbiota composition Open

Muhammad Waleed Iqbal, Muneer Ahmad, Muhammad Shahab, Xinxiao Sun, M. M. V. Baig , et al. · 2025

Comprehensive Transcriptomic Analysis of the Isolated Candida tropicalis with Enhanced Tolerance of Furfural Inhibitor Open

Jianguang Liu, Zifu Ni, Bingyu Jiao, Yuansen Hu, Zhongke Sun , et al. · 2025

The Candida tropicalis (C. tropicalis) named YB-3 was isolated by the Atmospheric and room temperature plasma mutagenesis from 6.5 g/L furfural tolerance. The comprehensive transcriptomic analysis of YB-3 was performed. During the stress o…

Global, regional, and national epidemiology of osteoarthritis in working-age individuals: insights from the global burden of disease study 1990–2021 Open

Weiwei Ma, Honggu Chen, Qipeng Yuan, Xiaoling Chen, Huanan Li · 2025

A new coumaric acid diglucoside-sebacic acid glycoside heterozygote compound in Butea monosperma Open

Qipeng Yuan, Jun Han · 2025

Analysis of damaging non-synonymous SNPs in GPx1 gene associated with the progression of diverse cancers through a comprehensive in silico approach Open

Muhammad Waleed Iqbal, Muhammad Shahab, Guojun Zheng, Xinxiao Sun, Qipeng Yuan , et al. · 2024

Biodegradation: the best solution to the world problem of discarded polymers Open

Jun Wu, Jiajie Wang, Yicheng Zeng, Xinxiao Sun, Qipeng Yuan , et al. · 2024

The widespread use of polymers has made our lives increasingly convenient by offering a more convenient and dependable material. However, the challenge of efficiently decomposing these materials has resulted in a surge of polymer waste, po…

Preparation and Immobilization Mechanism on a Novel Composite Carrier PDA-CF/PUF to Improve Cells Immobilization and Xylitol Production Open

Le Wang, Jianguang Liu, Yan Shen, Yanli Yin, Zifu Ni , et al. · 2024

The preparation of a novel composite carrier of polydopamine-modified carbon fiber/polyurethane foam (PDA-CF/PUF) was proposed to improve cell immobilization and the fermentation of xylitol, which is an important food sweetener and multifu…

Exploring the role of flavin-dependent monooxygenases in the biosynthesis of aromatic compounds Open

Tong Shi, Xinxiao Sun, Qipeng Yuan, Jia Wang, Xiaolin Shen · 2024

Hydroxylated aromatic compounds exhibit exceptional biological activities. In the biosynthesis of these compounds, three types of hydroxylases are commonly employed: cytochrome P450 (CYP450), pterin-dependent monooxygenase (PDM), and flavi…

Role of organic additives in the preparation of polyetherimide membranes for solvent resistant nanofiltration Open

Yuan Zhang, Beibei Luo, Jiandong Li, Qipeng Yuan · 2023

The incorporation of non-solvent organic additives in the casting solution has emerged as a significant technique in membrane fabrication. This approach enables the manipulation of membrane morphology and facilitates the preparation of hig…

Rational protein engineering of a ketoacids decarboxylase for efficient production of 1,2,4-butanetriol from arabinose Open

Xiaolin Shen, Hongchao Xu, Tong Wang, Ruihua Zhang, Xinxiao Sun , et al. · 2023

Background Lignocellulose, the most abundant non-edible feedstock on Earth, holds substantial potential for eco-friendly chemicals, fuels, and pharmaceuticals production. Glucose, xylose, and arabinose are primary components in lignocellul…

Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material Open

Ran Chen, Fanglin Du, Qipeng Yuan · 2023

Absorbable hemostatic materials have great potential in clinical hemostasis. However, their single coagulation mechanism, long degradation cycles, and limited functionality mean that they have restricted applications. Here, we prepared a s…

A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi Open

Qun Yue, Jie Meng, Yue Qiu, Miaomiao Yin, Liwen Zhang , et al. · 2023

Synthetic biology requires efficient systems that support the well-coordinated co-expression of multiple genes. Here, we discover a 9-bp nucleotide sequence that enables efficient polycistronic gene expression in yeasts and filamentous fun…

Biotechnology and Bioengineering: Volume 120, Number 2, February 2023 Open

Laura Colomina‐Alfaro, Silvia Marchesan, Artemis Stamboulis, Antonella Bandiera, Anurag S. Rathore , et al. · 2023

A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi Open

István Molnár, Shuobo Shi, Yuquan Xu, Qun Yue, Jie Meng , et al. · 2023

This is supplementary files of a full publication. In the publication, we reported the discovery of a 9-bp nucleotide sequence that enables the efficient translation of more than one protein from a polycistronic mRNA in yeasts and filament…

Nanogold: a versatile therapeutic agent in oncology Open

Mater H. Mahnashia, Bandar A. Alyami, Yahya S. Alqahtani, Qipeng Yuan, Arif Ullah Khan · 2022

Nanogold is an emerging and versatile therapeutic agent since decades. Nanoogold and its’complexes can be synthesized through different ways. Its’ use in oncology as a drug delivery vehicle, phothothermal agent, Nucliec acid delivery vehic…

Co-Immobilization of Lactase and Glucose Isomerase on the Novel g-C3N4/CF Composite Carrier for Lactulose Production Open

Le Wang, Bingyu Jiao, Yan Shen, Du Rong, Qipeng Yuan , et al. · 2022

The g-C3N4/CF composite carrier was prepared by ultrasound-assisted maceration and high-temperature calcination. The enzyme immobilization using the g-C3N4/CF as the novel carrier to immobilize lactase and glucose isomerase was enhanced fo…

Biosynthesis of plant hemostatic dencichine in Escherichia coli Open

Wenna Li, Zhao Zhou, Xianglai Li, Lin Ma, Qingyuan Guan , et al. · 2022

Coculture engineering for efficient production of vanillyl alcohol in Escherichia coli Open

Meichen Yang, Hao Meng, Xianglai Li, Jia Wang, Xiaolin Shen , et al. · 2022

Vanillyl alcohol is a precursor of vanillin, which is one of the most widely used flavor compounds. Currently, vanillyl alcohol biosynthesis still encounters the problem of low efficiency. In this study, coculture engineering was adopted t…

Parallel screening and cheminformatics modeling of flavonoid activated aptasensors Open

Yu Xiu, Ni Zhang, Pranesha Prabhakaran, Sungho Jang, Qipeng Yuan , et al. · 2022

Redesigning regulatory components of quorum-sensing system for diverse metabolic control Open

Chang Ge, Zheng Yu, Huakang Sheng, Xiaolin Shen, Xinxiao Sun , et al. · 2022

Quorum sensing (QS) is a ubiquitous cell–cell communication mechanism that can be employed to autonomously and dynamically control metabolic fluxes. However, since the functions of genetic components in the circuits are not fully understoo…

Synergistic utilization of carbon sources for efficient biosynthesis of N-acetylglucosamine Open

Yanni Pei, Yuhan Wang, Xiaolin Shen, Jia Wang, Xinxiao Sun , et al. · 2022

N-acetylglucosamine (GlcNAc) is an amino monosaccharide that has a variety of bioactivities and is widely used in pharmaceutical and food industries. Production of GlcNAc by chitin hydrolysis is limited by the supply of raw materials and e…

Design of stable and self-regulated microbial consortia for chemical synthesis Open

Xianglai Li, Zhao Zhou, Wenna Li, Yajun Yan, Xiaolin Shen , et al. · 2022

Co-Immobilizing Two Glycosidases by Combined Cross-Linked Enzyme Aggregates with Enhanced Enzymatic Properties Achieves High Titer Icaritin Biosynthesis Open

Fang Liu, Bin Wei, Leiyu Cheng, Xiaojie Liu, Qipeng Yuan , et al. · 2022

Groundwater remediation using Magnesium–Aluminum alloys and in situ layered doubled hydroxides Open

Jingqi Zhang, Hanjun Hu, Jingbo Chao, Yang Tang, Pingyu Wan , et al. · 2021

Preparation of ZIF@ADH/NAD-MSN/LDH Core Shell Nanocomposites for the Enhancement of Coenzyme Catalyzed Double Enzyme Cascade Open

Le Wang, Pengxue Sun, Yiyu Yang, Hanzhen Qiao, Hailong Tian , et al. · 2021

The field of enzyme cascades in limited microscale or nanoscale environments has undergone a quick growth and attracted increasing interests in the field of rapid development of systems chemistry. In this study, alcohol dehydrogenase (ADH)…

Rewiring the microbial metabolic network for efficient utilization of mixed carbon sources Open

Ning An, Xin Chen, Huakang Sheng, Jia Wang, Xinxiao Sun , et al. · 2021

Carbon sources represent the most dominant cost factor in the industrial biomanufacturing of products. Thus, it has attracted much attention to seek cheap and renewable feedstocks, such as lignocellulose, crude glycerol, methanol, and carb…

Enhanced Oral Absorption of Icaritin by Using Mixed Polymeric Micelles Prepared with a Creative Acid-Base Shift Method Open

Cheng Tang, Xiaohong Chen, Hua Yao, Haiyan Yin, Xiaoping Ma , et al. · 2021

The purpose of this study was to develop mixed polymeric micelles with high drug loading capacity to improve the oral bioavailability of icaritin with Soluplus® and Poloxamer 407 using a creative acid-base shift (ABS) method, which exhibit…

Preparation, Characterization, and In Vivo Evaluation of Amorphous Icaritin Nanoparticles Prepared by a Reactive Precipitation Technique Open

Cheng Tang, Kun Meng, Xiao‐Ming Chen, Hua Yao, Junqiong Kong , et al. · 2021

Icaritin is a promising anti-hepatoma drug that is currently being tested in a phase-III clinical trial. A novel combination of amorphization and nanonization was used to enhance the oral bioavailability of icaritin. Amorphous icaritin nan…

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