Qirong Xu
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View article: Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa
Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa Open
Overall, this study shed light on the functional importance of alternative splicing-generated circFTO and its coded FTO-36aa during myocardial hypertrophy. The findings provide fundamental insights into the mechanisms of m6A met…
View article: Multi-Functional Targeted Zwitterionic Block Copolymer Micelles Efficiently Transport Pznf580, Promoting Huvecs Proliferation and Migration
Multi-Functional Targeted Zwitterionic Block Copolymer Micelles Efficiently Transport Pznf580, Promoting Huvecs Proliferation and Migration Open
View article: Resection of a giant intraspinal and extraspinal schwannoma with cystic change using a two-step surgery: a case report
Resection of a giant intraspinal and extraspinal schwannoma with cystic change using a two-step surgery: a case report Open
View article: Global burden of ischemic stroke attributable to high body-mass index in 204 countries and territories, 1990–2019
Global burden of ischemic stroke attributable to high body-mass index in 204 countries and territories, 1990–2019 Open
Background A high body mass index (hBMI) is one of the major risk factors for ischemic stroke (IS), although independent estimates of the global burden and trend of IS attributable to hBMI are unclear. Methods Study data was extracted from…
View article: Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy via encoding a novel protein FTO-36aa
Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy via encoding a novel protein FTO-36aa Open
Background: Pathological cardiac hypertrophy poses a significant threat to human health by leading to ventricular remodeling. CircRNAs play a potential role in the dysregulation of cardiac hypertrophy and recent evidence highlights their t…
View article: Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation
Polyethylenimine-modified graphene quantum dots promote endothelial cell proliferation Open
Endothelial cell proliferation plays an important role in angiogenesis and treatment of related diseases. The aim of this study was to evaluate the effect of polyethylenimine (PEI)-modified graphene quantum dots (GQDs) gene vectors on endo…
View article: Exploring Dysregulated Ferroptosis-Related Genes in Septic Myocardial Injury Based on Human Heart Transcriptomes: Evidence and New Insights
Exploring Dysregulated Ferroptosis-Related Genes in Septic Myocardial Injury Based on Human Heart Transcriptomes: Evidence and New Insights Open
This study provides human septic heart transcriptome-based evidence and brings new insights into the role of ferroptosis in SMI, which is significant for expanding the understanding of the pathobiological mechanisms of SMI and exploring pr…
View article: Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy
Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy Open
Background: Myocardial ischemia/reperfusion injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanism of ischemia/reperfusion injury remains unclear. Mitochondria dysfunct…
View article: Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis
Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis Open
This study is designed to explore the role of long non-coding RNAs (lncRNAs) NCK1-AS1 in proliferative and invasive activities of esophageal squamous cell carcinoma (ESCC) cells by binding to microRNA-133b (miR-133b) to regulate ENPEP. Dif…
View article: Notch1 protectives against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and mitophagy
Notch1 protectives against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and mitophagy Open
Background Myocardial ischemia/reperfusion injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanism of ischemia/reperfusion injury remains unclear. Mitochondria dysfuncti…
View article: Notch1 protectives against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and mitophagy
Notch1 protectives against ischemic reperfusion injury via suppressing PTEN-Pink1 mediated mitochondrial dysfunction and mitophagy Open
Background Myocardial ischemia/reperfusion injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanism of ischemia/reperfusion injury remains unclear. Mitochondria dysfuncti…
View article: Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis
Long non-coding RNA NCK1-AS1 functions as a ceRNA to regulate cell viability and invasion in esophageal squamous cell carcinoma via microRNA-133b/ENPEP axis Open
This study is designed to explore the role of long non-coding RNAs (lncRNAs) NCK1-AS1 in proliferative and invasive activities of esophageal squamous cell carcinoma (ESCC) cells by binding to microRNA-133b (miR-133b) to regulate ENPEP. Dif…
View article: Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer
Long non-coding RNA MEG3 mediates the miR-149-3p/FOXP3 axis by reducing p53 ubiquitination to exert a suppressive effect on regulatory T cell differentiation and immune escape in esophageal cancer Open
Background Long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) has been implicated in the progression of esophageal cancer (EC). However, the specific mechanism of the involvement of MEG3 in EC development in relation to the re…
View article: Significance of tumor mutation burden and immune infiltration in thymic epithelial tumors
Significance of tumor mutation burden and immune infiltration in thymic epithelial tumors Open
Background Thymic epithelial tumors (TETs) are relatively rare malignant thoracic tumors. Tumor mutation burden (TMB) and immune infiltration play important roles in tumorigenesis. Methods Research data was obtained using the Cancer Genome…
View article: Inhibition of mitochondrial autophagy protects donor lungs for lung transplantation against ischaemia‐reperfusion injury in rats via the mTOR pathway
Inhibition of mitochondrial autophagy protects donor lungs for lung transplantation against ischaemia‐reperfusion injury in rats via the mTOR pathway Open
Impaired mitochondrial function is a key factor attributing to lung ischaemia‐reperfusion (IR) injury, which contributes to major post‐transplant complications. Thus, the current study was performed to investigate the role of mitochondrial…
View article: <scp>NSD</scp>2 promotes ventricular remodelling mediated by the regulation of H3K36me2
<span>NSD</span>2 promotes ventricular remodelling mediated by the regulation of H3K36me2 Open
Histone lysine methylation plays an important role in the regulation of ventricular remodelling. NSD 2 is involved in many types of tumours through enhancing H3K36me2 expression. However, the role of NSD 2 in the regulation of histone lysi…
View article: Role of autophagy and its signaling pathways in ischemia/reperfusion injury.
Role of autophagy and its signaling pathways in ischemia/reperfusion injury. Open
This study was conducted to investigate the mechanism of autophagy and its signaling pathways in ischemia/reperfusion injury (IRI). Pulmonary microvascular endothelial cells (PMVECs) were used to construct I/R models. The cells were then t…
View article: Genetic risk of lung cancer associated with a single nucleotide polymorphism from EXO1: a meta analysis.
Genetic risk of lung cancer associated with a single nucleotide polymorphism from EXO1: a meta analysis. Open
This first meta-analysis demonstrates that the A allele of EXO1 rs1047840 may confer modulating effects on the risk of lung cancer and could be used as a marker for early detection and primary prevention.
View article: Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition
Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition Open
Background/Aims: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are lethal diseases in humans, and the current treatments have limited therapeutic effects. Cordyceps militaris (CM) is a caterpillar-grown traditional…