Qishun Zhou
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View article: Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice
Phosphatidylethanolamine N-Methyltransferase Knockout Modulates Metabolic Changes in Aging Mice Open
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated with longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the bio…
View article: Phosphatidylethanolamine N-methyltransferase Knockout Modulates Metabolic Changes in Aging Mice
Phosphatidylethanolamine N-methyltransferase Knockout Modulates Metabolic Changes in Aging Mice Open
Phospholipid metabolism, including phosphatidylcholine (PC) biosynthesis, is crucial for various biological functions and is associated to longevity. Phosphatidylethanolamine N-methyltransferase (PEMT) is a protein that catalyzes the biosy…
View article: EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner
EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner Open
Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported. The hallmark of these diseases is the formation of pathological aggregates and fibrils in neural cells. M…
View article: Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism
Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism Open
Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and hav…
View article: Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism
Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism Open
Energy metabolism, including alterations in energy intake and expenditure, is closely related to aging and longevity. Metabolomics studies have recently unraveled changes in metabolite composition in plasma and tissues during aging and hav…
View article: Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation Open
Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation (LLPS) and stress granule (SGs) association of RG/RGG regions…
View article: ATP regulates RNA‐driven cold inducible RNA binding protein phase separation
ATP regulates RNA‐driven cold inducible RNA binding protein phase separation Open
Intrinsically disordered proteins and proteins containing intrinsically disordered regions are highly abundant in the proteome of eukaryotes and are extensively involved in essential biological functions. More recently, their role in the o…
View article: Oxidation of 5-methylaminomethyl uridine (mnm5U) by Oxone Leads to Aldonitrone Derivatives
Oxidation of 5-methylaminomethyl uridine (mnm5U) by Oxone Leads to Aldonitrone Derivatives Open
Oxidative RNA damage is linked to cell dysfunction and diseases. The present work focuses on the in vitro oxidation of 5-methylaminomethyl uridine (mnm5U), which belongs to the numerous post-transcriptional modifications that are found in …