Ping Xu
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View article: Study of the effectiveness of different pelvic floor muscle training methods for improving urinary incontinence in patients with prostate cancer after radical prostatectomy
Study of the effectiveness of different pelvic floor muscle training methods for improving urinary incontinence in patients with prostate cancer after radical prostatectomy Open
Introduction: To compare the effects of different pelvic floor muscle training (PFMT) modes on improving iatrogenic stress urinary incontinence (SUI) recovery in prostate cancer (PCa) patients after radical prostatectomy (RP). Metho…
View article: SRA1, APOA5, and AIFM2 identified as novel genetic risk factors in recurrent hypertriglyceridemia-associated acute pancreatitis by whole-exome sequencing
SRA1, APOA5, and AIFM2 identified as novel genetic risk factors in recurrent hypertriglyceridemia-associated acute pancreatitis by whole-exome sequencing Open
View article: Alcohol promoted prostate microbial imbalance in the rat model of prostatitis
Alcohol promoted prostate microbial imbalance in the rat model of prostatitis Open
Our findings suggested that alcohol exacerbates prostatitis by disrupting the balance of prostate microbiota. This finding could provide valuable insights for improving the diagnosis and treatment for patients with alcoholic prostatitis.
View article: STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation Open
View article: Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation
Cancer marker TNFRSF1A: From single‑cell heterogeneity of renal cell carcinoma to functional validation Open
During the progression of renal cell carcinoma (RCC), tumor growth, metastasis and treatment response heterogeneity are regulated by both the tumor itself and the tumor microenvironment (TME). The aim of the present study was to investigat…
View article: Evening versus morning dosing regimen drug therapy for hypertension
Evening versus morning dosing regimen drug therapy for hypertension Open
Due to the very limited data and the defects of the trials' designs, this systematic review did not find adequate evidence to determine which time dosing drug therapy regimen has more beneficial effects on cardiovascular outcomes or advers…
View article: RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer
RNA N6-methyladenosine demethylase FTO targets MOXD1 promoting the malignant phenotype of gastric cancer Open
Background The m6A modified demethylase FTO affects the progression of gastric cancer (GC), and the role mechanism of FTO in GC is still unclear. We, here, explored the role of FTO and unrevealed the mechanisms of its function in GC. Metho…
View article: Identification of prognostic biomarkers for hepatocellular carcinoma with vascular invasion
Identification of prognostic biomarkers for hepatocellular carcinoma with vascular invasion Open
The study indicates that 7 genes may be potential prognostic biomarkers and treatment targets for HCC patients with VI.
View article: Gastric adenocarcinoma in Situs inversus totalis: a case study and literature review
Gastric adenocarcinoma in Situs inversus totalis: a case study and literature review Open
Background Situs inversus totalis (SIT) is an uncommon disorder characterized by mirror-image anatomy, which can present unique challenges and potential vascular anomalies in surgical interventions, particularly in gastric cancer patients.…
View article: [Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression].
[Long non-coding RNA ABHD11-AS1 promotes glycolysis in gastric cancer cells to accelerate tumor progression]. Open
ABHD11-AS1 promotes glycolysis in gastric cancer cells by upregulating c-Myc to accelerate gastric cancer progression.
View article: Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9‐NF‐κB signaling pathway in severe acute pancreatitis
Mesenchymal stem cells regulate M1 polarization of peritoneal macrophages through the CARD9‐NF‐κB signaling pathway in severe acute pancreatitis Open
Background Macrophages release large numbers of proinflammatory cytokines that trigger inflammatory cascade reactions, which promote the rapid development of severe acute pancreatitis (SAP) from local to systemic inflammation. The ability …
View article: The application of transbronchial cryobiopsy in interstitial lung disease: a prospective, multicenter, real-world study
The application of transbronchial cryobiopsy in interstitial lung disease: a prospective, multicenter, real-world study Open
ClinicalTrials.gov; date of registration: 09/25/2018; registration number: NCT03704233; URL: clinicaltrials.gov.
View article: KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma
KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma Open
View article: Comparison of Three Prediction Rules for Assessing the Risk of Gastric Cancer in Chinese Health Examination Populations
Comparison of Three Prediction Rules for Assessing the Risk of Gastric Cancer in Chinese Health Examination Populations Open
Background The current consensus regarding gastric cancer screening in China recommends Li’s Scoring System to assess the risk of gastric cancer. Objectives To compare the predictive capacity of three prediction rules: the ABC method, the …
View article: STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway
STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway Open
Rationale: Protein kinases are critical therapeutic targets for curing hepatocellular carcinoma (HCC). As a serine/threonine kinase, the potential roles of serine/threonine kinase 39 (STK39) in HCC remain to be explored. Methods:…
View article: Physical exercise and economic burden associated with anxiety symptoms in pregnant women during the COVID-19 pandemic
Physical exercise and economic burden associated with anxiety symptoms in pregnant women during the COVID-19 pandemic Open
Background: COVID-19 with high infectivity and high concealment has been widely spread around the world. This major public health event has caused anxiety among the public, including pregnant women. The aim of this study was to assess the …
View article: Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis
Role of CARD9 in inflammatory signal pathway of peritoneal macrophages in severe acute pancreatitis Open
Previous studies revealed that caspase recruitment domain protein 9 (CARD9) was involved in severe acute pancreatitis (SAP) inflammation and that interfering with its expression in vivo could inhibit inflammation. However, the specific mec…
View article: Differential diagnosis of coronavirus disease 2019 from community acquired - pneumonia by CT scan and follow-up
Differential diagnosis of coronavirus disease 2019 from community acquired - pneumonia by CT scan and follow-up Open
Objective: Coronavirus disease 2019 (COVID-19) is currently the most serious infectious disease in the world. An accurate diagnosis of this disease in the clinic is very important. This study aims to improve the differential ability of com…
View article: Differential diagnosis of COVID-19 from community acquired pneumonia by CT scan and follow-up
Differential diagnosis of COVID-19 from community acquired pneumonia by CT scan and follow-up Open
ObjectiveCoronavirus disease-19(COVID-19) is the most serious infectious disease outbreak in the world at present. Accurate diagnosis of this disease in clinic is very important. this study aims to improve the differential ability of COVID…
View article: Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation
Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation Open
Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the function of these lncRNAs in cancer remains largely unexplored. Here, we reported that AFDN‐DT, an lncRNA…
View article: VPS33B suppresses lung adenocarcinoma metastasis and chemoresistance to cisplatin
VPS33B suppresses lung adenocarcinoma metastasis and chemoresistance to cisplatin Open
The presence of VPS33B in tumors has rarely been reported. Downregulated VPS33B protein expression is an unfavorable factor that promotes the pathogenesis of lung adenocarcinoma (LUAD). Overexpressed VPS33B was shown to reduce the migratio…
View article: Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice
Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice Open
There is increasing clinical evidence to suggest a suppressive effect on hematopoiesis in myelodysplastic syndrome patients with iron overload. However, how iron overload influences hematopoiesis in myelodysplastic syndrome (MDS) remains u…
View article: Phosphoinositide 3‑kinase/protein kinase B regulates inflammation severity via signaling of Toll‑like receptor 4 in severe acute pancreatitis
Phosphoinositide 3‑kinase/protein kinase B regulates inflammation severity via signaling of Toll‑like receptor 4 in severe acute pancreatitis Open
Phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) has been indicated to serve an important role in the pathogenesis of inflammatory diseases. It was previously demonstrated that the PI3K/Akt inhibitor wortmannin alleviated the se…
View article: RETRACTED ARTICLE: Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer
RETRACTED ARTICLE: Dual roles of miR-374a by modulated c-Jun respectively targets CCND1-inducing PI3K/AKT signal and PTEN-suppressing Wnt/β-catenin signaling in non-small-cell lung cancer Open
MiR-374a appears to play a complex role in non-small-cell lung cancer (NSCLC). Here, we demonstrate a dual role for miR-374a in NSCLC pathogenesis. The effects and modulatory mechanisms of miR-374a on cell growth, migration, invasion, and …
View article: Retraction notice for: Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis. [Braz J Med Biol Res (2018) 51(2): e6812]
Retraction notice for: Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis. [Braz J Med Biol Res (2018) 51(2): e6812] Open
Retraction for: Braz J Med Biol Res | doi: | PMID: 5731332 The authors would like to retract the article “Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis” that was published in volume 51 no…
View article: [RETRACTED ARTICLE] Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis
[RETRACTED ARTICLE] Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis Open
Caspase recruitment domain-containing protein 9 (Card9) is located upstream of the nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) inflammatory pathways. This study investigated the therapeutic effect and pot…
View article: Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer
Decreased expression of the long non-coding RNA MLLT4 antisense RNA 1 is a potential biomarker and an indicator of a poor prognosis for gastric cancer Open
In recent years, the identification of long non-coding RNAs (lncRNAs) led to the analysis of their characteristics in cancer biology. However, the expression of lncRNAs in cancer and their clinical significance remain unclear. In the prese…
View article: Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats
Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats Open
Nitrobenzylthioinosine (NBTI), a specific inhibitor of type 1 equilibrative nucleoside transporter, could regulate the extracellular adenosine concentration and have protective roles in seizures. However, the protection mechanism of NBTI i…
View article: Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis
Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis Open
Caspase recruitment domain-containing protein 9 (Card9) is located upstream of the nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) inflammatory pathways. This study investigated the therapeutic effect and pot…
View article: CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9‐dependent NF‐κB and P38MAPKs pathway
CARD9 gene silencing with siRNA protects rats against severe acute pancreatitis: CARD9‐dependent NF‐κB and P38MAPKs pathway Open
We previously reported the up‐regulation of caspase recruitment domain 9 ( CARD9 ) expressions in severe acute pancreatitis (SAP) patients, but little is known about its regulation. In this study, small interfering RNA (siRNA) was used to …