Qiu-Gui Zhang
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View article: Testing and analysis of automotive gearshift performance based on gear shift analysis
Testing and analysis of automotive gearshift performance based on gear shift analysis Open
With the increasing demand for vehicle handling comfort in the market, the development of gear shifting performance test systems for automobile transmission has become one of the keys to improving the competitiveness of automobile products…
View article: Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma <i>via</i> AMPK-FOXO1-ULK1 signaling axis-mediated autophagy
Histone deacetylase inhibitors promote epithelial-mesenchymal transition in Hepatocellular Carcinoma <i>via</i> AMPK-FOXO1-ULK1 signaling axis-mediated autophagy Open
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related deaths globally because of high metastasis and recurrence rates. Elucidating the molecular mechanisms of HCC recurrence and metastasis and developing effecti…
View article: Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells
Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-β1-induced epithelial-mesenchymal transitions in hepatoma cells Open
Hepatocellular carcinoma (HCC) remains the third cause of cancer-related mortality. Resection and transplantation are the only curative treatments available but are greatly hampered by high recurrence rates and development of metastasis, t…
View article: microRNA-889 is downregulated by histone deacetylase inhibitors and confers resistance to natural killer cytotoxicity in hepatocellular carcinoma cells
microRNA-889 is downregulated by histone deacetylase inhibitors and confers resistance to natural killer cytotoxicity in hepatocellular carcinoma cells Open
View article: The application of the fibroblast activation protein α-targeted immunotherapy strategy
The application of the fibroblast activation protein α-targeted immunotherapy strategy Open
Cancer immunotherapy has primarily been focused on attacking tumor cells. However, given the close interaction between tumor cells and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME), CAF-targeted strategies could …
View article: Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma
Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma Open
Fibroblast activation protein α (FAPα) is a potential target for cancer therapy. However, elimination of FAPα+ fibroblasts activates secretion of IFN-γ and TNF-α. IFN-γ can in turn induce expression indolamine-2,3-dioxygenase (IDO), thereb…