Qiuling Fan
YOU?
Author Swipe
View article: In vivo pharmacokinetic evaluation of molnupiravir in patients with severe chronic kidney disease
In vivo pharmacokinetic evaluation of molnupiravir in patients with severe chronic kidney disease Open
Introduction Molnupiravir (MPV) is an oral, potent ribonucleoside analog that inhibits the replication of SARS-CoV-2 and is indicated for the treatment of adults with COVID-19. Patients with COVID-19 are at an elevated risk of adverse outc…
View article: METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy Open
METTL3 targets TUG1/PGC-1α and ameliorates mitochondrial dysfunction in diabetic nephropathy in an IGF2BP2-dependent manner.
View article: Diagnostic value of the correlation between urinary MDM2 and podocyte mitotic catastrophe in diabetic kidney disease
Diagnostic value of the correlation between urinary MDM2 and podocyte mitotic catastrophe in diabetic kidney disease Open
We observed that PMC and elevated urinary MDM2/Cr levels emerged early in DKD. Additionally, we developed a diagnostic panel combining urinary MDM2/Cr and SP/Cr, which might serve as a predictive tool for early DKD diagnosis and prevention.
View article: Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease
Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease Open
This study presents a validated, noninvasive, multi-center Scr-based machine learning model for assessing kidney fibrosis severity in CKD. The integration of a clinical nomogram and ML approach offers a novel, practical alternative to biop…
View article: Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs
Pulsed electromagnetic fields treatment ameliorates cardiac function after myocardial infarction in mice and pigs Open
PEMF treatment exhibits considerable promise as a noninvasive physical therapy modality, warranting further investigation into its potential implications for managing patients with IHD.
View article: Corrigendum to “The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota” [Volume 10, Issue 2, February 2025, Pages 522-534]
Corrigendum to “The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota” [Volume 10, Issue 2, February 2025, Pages 522-534] Open
[This corrects the article DOI: 10.1016/j.ekir.2024.11.022.].
View article: N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1
N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1 Open
Our findings suggest that the m6A modification of GLIS1, activated by METTL3 and reduced in a YTHDF1-dependent manner, leads to kidney aging by regulating the metabolic shift from FAO to glycolysis. This mechanism provides a promising ther…
View article: The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota
The Bromodomain and Extraterminal Protein Inhibitor Apabetalone Ameliorates Kidney Injury in Diabetes by Regulating Cholesterol Accumulation and Modulating the Gut Microbiota Open
Therefore, we suggest that apabetalone showed significant antihyperlipidemic and antifibrotic effects, closely associated with alterations in the gut microbiota and cholesterol metabolism. The results of this investigation provide fresh pe…
View article: The Selective Endothelin Receptor Antagonist SC0062 in IgA Nephropathy
The Selective Endothelin Receptor Antagonist SC0062 in IgA Nephropathy Open
Key Points Patients with IgA nephropathy and significant proteinuria are at high risk of progressive kidney function loss and kidney failure. We report the results of a clinical trial assessing the selective endothelin receptor antagonist …
View article: Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice
Lactococcus strains with psychobiotic properties improve cognitive and mood alterations in aged mice Open
Aging often accompanies cognitive and mood disturbances. Emerging evidence indicates that specific probiotics mitigate cognitive and mood dysfunctions. Strains within Lactococcus , a subgroup of probiotics, including Lactococcus lactis and…
View article: Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis
Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis Open
Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with pyroptosis, a type of inflammation-regulated cell death. The purpose of this work was to ascertain the effects of apabetalone, which targets BRD4, a …
View article: Association of dietary live microbe intake with diabetic kidney disease in patients with type 2 diabetes mellitus in US adults: a cross-sectional study of NHANES 1999–2018
Association of dietary live microbe intake with diabetic kidney disease in patients with type 2 diabetes mellitus in US adults: a cross-sectional study of NHANES 1999–2018 Open
Aims Several studies have reported dietary microorganisms’ beneficial effects on human health. We aimed to detect the potential association between dietary live microbe intake and diabetic kidney disease (DKD) in patients with type 2 diabe…
View article: The supplementation of the multi-strain probiotics WHHPRO™ alleviates high-fat diet-induced metabolic symptoms in rats via gut-liver axis
The supplementation of the multi-strain probiotics WHHPRO™ alleviates high-fat diet-induced metabolic symptoms in rats via gut-liver axis Open
Metabolic syndrome (MS) has emerged as one of the major global health concerns, accompanied by a series of related complications, such as obesity and type-2 diabetes. The gut-liver axis (GLA) is a bidirectional communication between the gu…
View article: GLIS1 alleviates cell senescence and renal fibrosis through PGC1-α mediated mitochondrial quality control in kidney aging
GLIS1 alleviates cell senescence and renal fibrosis through PGC1-α mediated mitochondrial quality control in kidney aging Open
Mitochondrial dysfunction is implied as a crucial factor in age-related chronic kidney disease. It is confirmed that Gli-like transcription factor 1 (GLIS1) is involved in age-related renal fibrosis, however, the correlation between mitoch…
View article: The relevance of the non-invasive biomarkers lncRNA GAS5/miR-21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy
The relevance of the non-invasive biomarkers lncRNA GAS5/miR-21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy Open
Background To investigate the diagnostic value of serum lncRNA growth arrest-specific transcript 5 (lncRNA GAS5) and microRNA-21 (miR-21) in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and elucidate their r…
View article: <i>Leuconostoc mesenteroides</i> WHH1141 ameliorates ovalbumin‐induced food allergy in mice
<i>Leuconostoc mesenteroides</i> WHH1141 ameliorates ovalbumin‐induced food allergy in mice Open
Food allergy (FA) is acknowledged as a significant public health and food safety issue, due to its manifestation as an amplified immune reaction to food antigens. Recently, probiotics within Lactobacillus and Bifidobacterium have been high…
View article: Improvements of Age-Related Cognitive Decline in Mice by Lactobacillus helveticus WHH1889, a Novel Strain with Psychobiotic Properties
Improvements of Age-Related Cognitive Decline in Mice by Lactobacillus helveticus WHH1889, a Novel Strain with Psychobiotic Properties Open
A gradual decline in cognitive function occurs with age. Accumulating evidence suggests that certain probiotic strains exert beneficial effects on age-related cognitive decline. Our previous study revealed that Lactobacillus helveticus WHH…
View article: Revisiting Scalarization in Multi-Task Learning: A Theoretical Perspective
Revisiting Scalarization in Multi-Task Learning: A Theoretical Perspective Open
Linear scalarization, i.e., combining all loss functions by a weighted sum, has been the default choice in the literature of multi-task learning (MTL) since its inception. In recent years, there is a surge of interest in developing Special…
View article: The relevance of the non-invasive biomarkers lncRNA GAS5/miR- 21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy
The relevance of the non-invasive biomarkers lncRNA GAS5/miR- 21 ceRNA regulatory network in the early identification of diabetes and diabetic nephropathy Open
Background To investigate the diagnostic value of serum lncRNA growth arrest-specific transcript 5 (lncRNA GAS5) and microRNA-21 (miR-21) in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and elucidate their r…
View article: Engineering of cyclodextrin glycosyltransferase improves the conversion efficiency of rebaudioside A to glucosylated steviol glycosides and increases the content of short-chain glycosylated steviol glycoside
Engineering of cyclodextrin glycosyltransferase improves the conversion efficiency of rebaudioside A to glucosylated steviol glycosides and increases the content of short-chain glycosylated steviol glycoside Open
Background Compared with steviol glycosides, the taste of glucosylated steviol glycosides is better and more similar to that of sucrose. At present, cyclodextrin glucanotransferase (CGTase) is primarily used to catalyze the conversion of s…
View article: METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification
METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification Open
Background: m6A modification plays an important role in various biological processes and can regulate the function of non-coding RNA. Our research group found the m6A level of lncRNA TUG1 was reduced in HK-2 cells cultured with high glucos…
View article: METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification
METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification Open
Background: m6A modification plays an important role in various biological processes and can regulate the function of non-coding RNA. Our research group found the m6A level of lncRNA TUG1 was reduced in HK-2 cells cultured with high glucos…
View article: YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway
YY1-induced upregulation of LncRNA-ARAP1-AS2 and ARAP1 promotes diabetic kidney fibrosis via aberrant glycolysis associated with EGFR/PKM2/HIF-1α pathway Open
Objectives: Dimeric pyruvate kinase (PK) M2 (PKM2) plays an important role in promoting the accumulation of hypoxia-inducible factor (HIF)-1α, mediating aberrant glycolysis and inducing fibrosis in diabetic kidney disease (DKD). The aim of…
View article: Bibliometric and visualized analysis of sodium–Glucose cotransporter 2 inhibitors
Bibliometric and visualized analysis of sodium–Glucose cotransporter 2 inhibitors Open
Background: Sodium—glucose cotransporter 2 inhibitors have proved to be extremely effective and reliable in reducing hyperglycemia, and have also been used for the treatment of cardiovascular and renal disease in patients with or without t…
View article: Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018
Association between the composite dietary antioxidant index and chronic kidney disease: evidence from NHANES 2011–2018 Open
There is growing evidence that antioxidant-rich diets protect against chronic kidney disease (CKD).
View article: Genetically predicted body fat mass and distribution with diabetic kidney disease: A two-sample Mendelian randomization study
Genetically predicted body fat mass and distribution with diabetic kidney disease: A two-sample Mendelian randomization study Open
The aim of this study is to apply a Mendelian randomization (MR) design to investigate the potential causal associations between the body mass index (BMI), body fat mass such as trunk fat mass and waist circumference (WC), and diabetic kid…