Qiuling Wu
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View article: Impact of Xpert® Carba-R-based screening for carbapenem-resistant organisms on infection-related mortality in hematopoietic stem cell transplant recipients
Impact of Xpert® Carba-R-based screening for carbapenem-resistant organisms on infection-related mortality in hematopoietic stem cell transplant recipients Open
Background The emergence of carbapenem-resistant organisms (CROs) poses a major challenge to clinical infection control in hospitals. Patients undergoing hematopoietic stem cell transplants (HSCTs) infected with CROs are at high risk of mo…
View article: Single-center experience with mitoxantrone hydrochloride liposome-based therapy for patients with myeloid sarcoma
Single-center experience with mitoxantrone hydrochloride liposome-based therapy for patients with myeloid sarcoma Open
Background: Myeloid sarcoma (MS) accounts for 3% to 8% of acute myeloid leukemia (AML) cases and is characterized by an extramedullary tumor mass composed of myeloid blasts, with or without bone marrow involvement. The heterogeneity of MS …
View article: Predictive Values of Echocardiographic Parameters Combined with Platelet Indices for the Sustained Opening of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants
Predictive Values of Echocardiographic Parameters Combined with Platelet Indices for the Sustained Opening of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants Open
Patent ductus arteriosus (PDA) is a prevalent congenital cardiac anomaly in neonates. It is characterized by substantial hemodynamic alterations owing to large shunt volumes and is referred to as hemodynamically significant PDA (hsPDA). hs…
View article: Diagnostic accuracy of automated breast volume scanning, hand-held ultrasound and molybdenum-target mammography for breast lesions: a systematic review and meta-analysis
Diagnostic accuracy of automated breast volume scanning, hand-held ultrasound and molybdenum-target mammography for breast lesions: a systematic review and meta-analysis Open
Meta-analysis found a higher diagnostic accuracy of ABVS in benign and malignant breast lesions. These results provide a reference for clinical practitioners in the selection of diagnostic methods, but considering the possible bias of the …
View article: The Efficacy and Safety of Selinexor in Combination with Ruxolitinib in Ruxolitinib-Treated Myelofibrosis Patients: The Interim Analysis of a Prospective, Open-Label, Multicenter, Parallel-Cohort, Phase 2 Study
The Efficacy and Safety of Selinexor in Combination with Ruxolitinib in Ruxolitinib-Treated Myelofibrosis Patients: The Interim Analysis of a Prospective, Open-Label, Multicenter, Parallel-Cohort, Phase 2 Study Open
Background: Myelofibrosis is a chronic hematologic malignancy characterized by constitutional symptoms, bone marrow fibrosis, extramedullary hematopoiesis resulting in splenomegaly and a propensity toward leukemic progression. Although JAK…
View article: Efficacy and Safety of Single-Dose Versus Split-Dose Mecapegfilgrastim with Etoposide for Autologous Peripheral Blood Stem Cell Mobilization: A Prospective, Randomized Clinical Trial
Efficacy and Safety of Single-Dose Versus Split-Dose Mecapegfilgrastim with Etoposide for Autologous Peripheral Blood Stem Cell Mobilization: A Prospective, Randomized Clinical Trial Open
High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (auto-HSCT) is a well-established consolidation treatment for lymphoma and multiple myeloma, reducing relapse risk and improving survival. Effective mo…
View article: Effects of self-management education integrated nursing on cancer patients with PICC placement: a systematic review and meta-analysis
Effects of self-management education integrated nursing on cancer patients with PICC placement: a systematic review and meta-analysis Open
Background: Chemotherapy plays an important role in cancer treatment. Peripherally inserted central catheter (PICC) is an important vascular access device used in cancer patients undergoing chemotherapy. Objective: This review entailed an …
View article: New <i>ABL1</i> Kinase Domain Mutations in <i>BCR::ABL1</i>‐Positive Acute Lymphoblastic Leukemia
New <i>ABL1</i> Kinase Domain Mutations in <i>BCR::ABL1</i>‐Positive Acute Lymphoblastic Leukemia Open
Background Since the development of the first‐generation Tyrosine Kinase Inhibitor (TKI), it has played a crucial role in the treatment of BCR::ABL1 ‐positive acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML). However, …
View article: Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology
Mechanism Actions of Coniferyl Alcohol in Improving Cardiac Dysfunction in Renovascular Hypertension Studied by Experimental Verification and Network Pharmacology Open
Renovascular hypertension (RH), a secondary hypertension, can significantly impact heart health, resulting in heart damage and dysfunction, thereby elevating the risk of cardiovascular diseases. Coniferol (CA), which has vascular relaxatio…
View article: Isoxanthohumol improves hepatic lipid metabolism via regulating the <scp>AMPK</scp> / <scp>PPARα</scp> and <scp>PI3K</scp> / <scp>AKT</scp> signaling pathways in hyperlipidemic mice
Isoxanthohumol improves hepatic lipid metabolism via regulating the <span>AMPK</span> / <span>PPARα</span> and <span>PI3K</span> / <span>AKT</span> signaling pathways in hyperlipidemic mice Open
Hyperlipidemia presents a significant global healthcare challenge, necessitating innovative therapeutic strategies for more effective outcomes. Recent studies have highlighted the beneficial impact of moderate beer intake on metabolic dise…
View article: Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: Unveiling their roles in the modulation of platelet activation and thrombus formation
Elucidating the distinctive regulatory effects and mechanisms of active compounds in Salvia miltiorrhiza Bunge via network pharmacology: Unveiling their roles in the modulation of platelet activation and thrombus formation Open
Salvia miltiorrhiza Bunge. (DS), as an important traditional Chinese medicine (TCM), has a long history of usage for promoting blood circulation and removing blood stasis. Modern studies have shown that the chemical components of DS have m…
View article: ALKHB5-demethylated lncRNA SNHG15 promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier SETD2
ALKHB5-demethylated lncRNA SNHG15 promotes myeloma tumorigenicity by increasing chromatin accessibility and recruiting H3K36me3 modifier SETD2 Open
To our knowledge, this study first demonstrated the prognostic significance and biological function of long noncoding RNA (lncRNA) small nucleolar RNA host gene 15 (SNHG15) in multiple myeloma (MM), and indicated a novel revelation on the …
View article: P1528: DIAGNOSTIC AND THERAPEUTIC EVALUATION OF CARBAPENEM-RESISTANT ORGANISMS BLOODSTREAM INFECTION FROM GUT COLONIZATION IN HSCT PATIENTS UNDERWENT CARBAPENEMASE GENES GUIDED THERAPY
P1528: DIAGNOSTIC AND THERAPEUTIC EVALUATION OF CARBAPENEM-RESISTANT ORGANISMS BLOODSTREAM INFECTION FROM GUT COLONIZATION IN HSCT PATIENTS UNDERWENT CARBAPENEMASE GENES GUIDED THERAPY Open
Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Recently, the worldwide spread of carbapenem-resistant organisms (CRO) arose as a rigorous medical and public health problem. Carbapenemase-producing(CP) is th…
View article: P1052: A REAL-WORLD STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SELINEXOR IN COMBINATION WITH RUXOLITINIB IN PATIENTS WITH MYELOFIBROSIS
P1052: A REAL-WORLD STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SELINEXOR IN COMBINATION WITH RUXOLITINIB IN PATIENTS WITH MYELOFIBROSIS Open
Topic: 16. Myeloproliferative neoplasms - Clinical Background: Selinexor (SEL) is a first-in-class, oral selective inhibitor of nuclear export agent that binds the karyopherin protein exportin 1 (XPO1). Myelofibrosis (MF) is a hematopoieti…
View article: P824: LNCRNA SNHG15 BINDS DDX5 TO INDUCE R-LOOP-BASED DNA DAMAGE REPAIR TO PROMOTE BTZ RESISTANCE IN MULTIPLE MYELOMA
P824: LNCRNA SNHG15 BINDS DDX5 TO INDUCE R-LOOP-BASED DNA DAMAGE REPAIR TO PROMOTE BTZ RESISTANCE IN MULTIPLE MYELOMA Open
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: So far, the introduction of immunomodulatory drugs, proteasome inhibitors, and CD38-targeting antibodies has extended survival of multiple …
View article: Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma
Comprehensive analysis of prognosis of cuproptosis-related oxidative stress genes in multiple myeloma Open
Introduction: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy. The patients’ survival outcomes vary widely. Establishing a more accurate prognostic model is necessary to improve prognostic precision and guide clinica…
View article: The application of nanopore targeted sequencing in the diagnosis and antimicrobial treatment guidance of bloodstream infection of febrile neutropenia patients with hematologic disease
The application of nanopore targeted sequencing in the diagnosis and antimicrobial treatment guidance of bloodstream infection of febrile neutropenia patients with hematologic disease Open
Traditional microbiological methodology has limited sensitivity, detection range, and turnaround times in diagnosis of bloodstream infection in Febrile Neutropenia (FN) patients. A more rapid and sensitive detection technology is urgently …
View article: A Visualized Mortality Prediction Score Model in Hematological Malignancies Patients with Carbapenem-Resistant Organisms Bloodstream Infection
A Visualized Mortality Prediction Score Model in Hematological Malignancies Patients with Carbapenem-Resistant Organisms Bloodstream Infection Open
Our score model can accurately predict 30-day mortality in HM patients with CROs BSI. Early administration of CROs-targeted therapy in the high-risk group is strongly recommended to decrease mortality.
View article: A Novel Risk Predictive Scoring Model for Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization in Hematological Malignancy Patients
A Novel Risk Predictive Scoring Model for Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization in Hematological Malignancy Patients Open
Background This study investigated the high-risk factors associated with the increased vulnerability for subsequent clinical CR-GNB infection in carbapenem-resistant Gram-negative bacteria (CR-GNB)-colonized hematological malignancy (HM) p…
View article: Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review
Acute Promyelocytic Leukemia Presenting With a Myeloid Sarcoma of the Spine: A Case Report and Literature Review Open
Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells. Certain known acute myeloid leukemia cytogenetic abnormalities, in particular t(8,21), has been associated with a higher incidence. Myeloid sarcoma, which rarely hap…
View article: Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing
Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing Open
Background Adult T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous malignant tumor with poor prognosis. However, accurate prognostic stratification factors are still unclear. Methods Data from 90 adult T-cell acute lymphoblast…
View article: PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population
PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population Open
As an important member of the Argonaute protein family, PIWI-like protein 1 (PIWIL1) plays a key role in tumor cell viability. However, the exact function of PIWIL1 in multiple myeloma (MM) and the underlying mechanism remain unclear. Here…
View article: ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m<sup>6</sup>A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype
ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m<sup>6</sup>A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype Open
N6-methyladenosine (m6A) is the most prevalent modification to RNA in higher eukaryotes. ALKBH5 is an RNA demethylase that impacts RNA export and metabolism, and its aberrant expression is associated with the generation of tumours. In this…
View article: A Novel Risk Predictive Scoring Model For Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization In Hematological Malignancies Patients
A Novel Risk Predictive Scoring Model For Predicting Subsequent Infection After Carbapenem-Resistant Gram-Negative Bacteria Colonization In Hematological Malignancies Patients Open
Purpose To investigate the high-risk factors associated with the increased vulnerability for subsequent clinical infection in Carbapenem-resistant Gram-negative bacteria (CR-GNB) colonized hematological malignancies (HMs) patients, and bui…
View article: The role of E255K/V-inclusive mutations in a Philadelphia-positive acute lymphoblastic leukemia with mutation evolution during sequential TKIs therapies
The role of E255K/V-inclusive mutations in a Philadelphia-positive acute lymphoblastic leukemia with mutation evolution during sequential TKIs therapies Open
Rationale: Until recently, the survival rate in patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) was approximately 30%. Tyrosine kinase inhibitors (TKIs), which are a new class of drugs that target BCR-ABL fusion …