Qiumin Tan
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View article: Capicua Refines Mossy Fiber–CA3 Axon Targeting in the Late Postnatal Hippocampus
Capicua Refines Mossy Fiber–CA3 Axon Targeting in the Late Postnatal Hippocampus Open
Proper brain wiring relies on the precise distribution of axonal projections to specific subcellular domains of their target neurons. These spatially confined connections establish the anatomical foundation for neural circuit assembly. The…
View article: Loss of <scp>NFIA</scp> Impairs Adult Hippocampal Neurogenesis
Loss of <span>NFIA</span> Impairs Adult Hippocampal Neurogenesis Open
Adult hippocampal neurogenesis (AHN) is the process by which new neurons are continuously generated from neural stem and progenitor cells (NSPCs) in the adult dentate gyrus. AHN plays a pivotal role in cognitive functions, including learni…
View article: Capicua regulates the survival of Cajal-Retzius cells in the postnatal hippocampus
Capicua regulates the survival of Cajal-Retzius cells in the postnatal hippocampus Open
Programmed cell death is crucial for organ morphogenesis and tissue homeostasis. Understanding programmed cell death in the developing brain is essential for comprehending both normal brain development and neurological disorders. In this s…
View article: Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice Open
View article: <scp>MATR3</scp> pathogenic variants differentially impair its cryptic splicing repression function
<span>MATR3</span> pathogenic variants differentially impair its cryptic splicing repression function Open
Matrin‐3 (MATR3) is an RNA‐binding protein implicated in neurodegenerative and neurodevelopmental diseases. However, little is known regarding the role of MATR3 in cryptic splicing within the context of functional genes and how disease‐ass…
View article: Differential effects of MATR3 variants on its cryptic splicing repression function
Differential effects of MATR3 variants on its cryptic splicing repression function Open
MATR3 is an RNA-binding protein implicated in neurodegenerative and neurodevelopmental diseases. However, little is known regarding the role of MATR3 in cryptic splicing within the context of functional genes and how disease-associated var…
View article: A Versatile Strategy for Genetic Manipulation of Cajal–Retzius Cells in the Adult Mouse Hippocampus
A Versatile Strategy for Genetic Manipulation of Cajal–Retzius Cells in the Adult Mouse Hippocampus Open
Cajal–Retzius (CR) cells are transient neurons with long-lasting effects on the architecture and circuitry of the neocortex and hippocampus. Contrary to the prevailing assumption that CR cells completely disappear in rodents shortly after …
View article: Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice Open
Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility …
View article: Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice Open
Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility …
View article: Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis
Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis Open
B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 cell development at the adult stage. We report that cap…
View article: Capicua regulates the development of adult-born neurons in the hippocampus
Capicua regulates the development of adult-born neurons in the hippocampus Open
New neurons continuously arise from neural progenitor cells in the dentate gyrus of the adult hippocampus to support ongoing learning and memory formation. To generate functional adult-born neurons, neural progenitor cells proliferate to e…
View article: Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS
Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS Open
View article: Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis
Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis Open
Significance Over 200 genomic loci have been found associated with the risk of developing multiple sclerosis (MS). Despite this important body of data, limited information exists on the cellular pathways and molecular mechanisms underlying…
View article: Raw immunofluorescence and immunohistochemistry images of MATR3 S85C knock-in mice
Raw immunofluorescence and immunohistochemistry images of MATR3 S85C knock-in mice Open
This data record contains a total of 252 data files.These are: Image_file_names.xlsx data file, containing descriptions for the 251 raw image files.136 x .tif image files (these are H&E images of muscles)19 x .lsm files
View article: Function of pea amino acid permease AAP6 in nodule nitrogen metabolism and export, and plant nutrition
Function of pea amino acid permease AAP6 in nodule nitrogen metabolism and export, and plant nutrition Open
Legumes fix atmospheric nitrogen through a symbiotic relationship with bacteroids in root nodules. Following fixation in pea (Pisum sativum L.) nodules, nitrogen is reduced to amino acids that are exported via the nodule xylem to the shoot…
View article: PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1
PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1 Open
Spinocerebellar ataxia type 1 (SCA1) is caused by the expansion of a trinucleotide repeat that encodes a polyglutamine tract in ataxin-1 (ATXN1). The expanded polyglutamine in ATXN1 increases the protein's stability and results in its accu…
View article: ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism Open
View article: Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma
Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma Open
Capicua (CIC) regulates a transcriptional network downstream of the RAS/MAPK signaling cascade. In Drosophila , CIC is important for many developmental processes, including embryonic patterning and specification of wing veins. In humans, C…
View article: Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans
Disruption of the ATXN1–CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans Open
View article: Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models
Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models Open
Splicing regulation is an important step of post-transcriptional gene regulation. It is a highly dynamic process orchestrated by RNA-binding proteins (RBPs). RBP dysfunction and global splicing dysregulation have been implicated in many hu…