Qiuping Liu
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View article: Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy
Aqueous humor levels of syndecan-1 and syndecan-4 associated with OCTA metrics in diabetic retinopathy Open
Purpose Attenuated endothelium glycocalyx had been shown to be related to vascular damage during diabetic retinopathy (DR). Syndecans were pivotal components of retinal glycocalyx, which could be released from the endothelial surface by a …
View article: The impact of Hashimoto’s thyroiditis on endoscopic thyroidectomy in patients with papillary thyroid carcinoma
The impact of Hashimoto’s thyroiditis on endoscopic thyroidectomy in patients with papillary thyroid carcinoma Open
Background Hashimoto’s thyroiditis (HT) is often associated with papillary thyroid carcinoma (PTC) and increases the difficulty of thyroidectomy. The clinical outcomes of applying the transoral approach and the transthoracic approach—the t…
View article: Medical World Model: Generative Simulation of Tumor Evolution for Treatment Planning
Medical World Model: Generative Simulation of Tumor Evolution for Treatment Planning Open
Providing effective treatment and making informed clinical decisions are essential goals of modern medicine and clinical care. We are interested in simulating disease dynamics for clinical decision-making, leveraging recent advances in lar…
View article: A Comprehensive Review of Plant Volatile Terpenoids, Elucidating Interactions with Surroundings, Systematic Synthesis, Regulation, and Targeted Engineering Production
A Comprehensive Review of Plant Volatile Terpenoids, Elucidating Interactions with Surroundings, Systematic Synthesis, Regulation, and Targeted Engineering Production Open
Plants require a flexible avoidance mechanism as they need to cope with external stimuli and challenges through complex specialized metabolites, among which volatile terpenoids make outstanding contributions, acting as key media signal sub…
View article: The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells
The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells Open
Review The Metabolic Underpinnings of Retinal Health and Disease: A Focus on Photoreceptor Cells Jianbo Jin 1,2, Qiuping Liu 3,*, and Cheng Li 1,2,4,* 1 Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, X…
View article: Ursolic acid ameliorates ocular surface dysfunction in dry eye via targeting EGFR/RAS/RAF/MAP2K1/MAPK1 pathway
Ursolic acid ameliorates ocular surface dysfunction in dry eye via targeting EGFR/RAS/RAF/MAP2K1/MAPK1 pathway Open
Dry eye (DE), a multifactorial ocular surface disease, is predominantly characterized by inflammation as a central pathological factor. Ursolic acid (UA), a pentacyclic triterpenoid with well-documented anti-inflammatory properties, was ev…
View article: Region‐guided focal adversarial learning for CT‐to‐MRI translation: A proof‐of‐concept and validation study in hepatocellular carcinoma
Region‐guided focal adversarial learning for CT‐to‐MRI translation: A proof‐of‐concept and validation study in hepatocellular carcinoma Open
Background Generative adversarial networks (GANs) have recently demonstrated significant potential for producing virtual images with the same characteristics as real‐life landscapes, thereby enhancing various medical tasks. Purpose To desi…
View article: Photosynthetic Induction Characteristics in Saplings of Four Sun-Demanding Trees and Shrubs
Photosynthetic Induction Characteristics in Saplings of Four Sun-Demanding Trees and Shrubs Open
Light serves as the unique driving force of photosynthesis in plants, yet its intensity varies over time and space, leading to corresponding changes in the photosynthetic rate. Here, the photosynthetic induction response under constant and…
View article: Visible-light-induced photocatalytic oxidation of C–H bonds with O <sub>2</sub> employing simple porphyrins as photocatalysts under solvent-free conditions
Visible-light-induced photocatalytic oxidation of C–H bonds with O <sub>2</sub> employing simple porphyrins as photocatalysts under solvent-free conditions Open
An efficient, low-energy consumption, low-carbon emission and sustainable oxidation of C–H bonds with O 2 was realized utilizing porphyrins as photocatalysts under irradiation of visible light, and a successful reference of learning from n…
View article: Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography
Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography Open
View article: Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma
Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma Open
Introduction Liver cirrhosis (LC) and hepatocellular carcinoma (HCC) resulting from chronic hepatitis B virus (HBV) infection are major health concerns. Identifying critical biomarkers and molecular targets is needed for early diagnosis, p…
View article: Grid-based Analysis of Three-Dimensional Choroidal Sattler's and Haller's Layer Vascularity Volume Index and its Relation to Age and Axial Length in Adults by Ultra-Widefield Swept-source Optical Coherence Tomography Angiography
Grid-based Analysis of Three-Dimensional Choroidal Sattler's and Haller's Layer Vascularity Volume Index and its Relation to Age and Axial Length in Adults by Ultra-Widefield Swept-source Optical Coherence Tomography Angiography Open
Background. This study was to evaluate the features of choroidal Sattler’s and Haller’s layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefi…
View article: Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration
Comparative study between swept-source and spectral-domain OCTA for imaging of choroidal neovascularization in age-related macular degeneration Open
AIM: To compare the differences of choroidal neovascularization (CNV) measurements between swept-source and spectral-domain optical coherence tomography angiography (SS-OCTA and SD-OCTA) in neovascular age-related macular degeneration (nAM…
View article: Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1
Sodium danshensu modulates skeletal muscle fiber type formation and metabolism by inhibiting pyruvate kinase M1 Open
Sodium Danshensu (SDSS) is extracted from Salvia miltiorrhiza and has many pharmacological effects. However, little is known about its effects on muscle fiber formation and metabolism. Here, we aimed to investigated the role and molecular …
View article: CHARACTERISTICS OF “NOTCH” IN RETINOPATHY OF PREMATURITY AFTER INTRAVITREAL RANIBIZUMAB MONOTHERAPY
CHARACTERISTICS OF “NOTCH” IN RETINOPATHY OF PREMATURITY AFTER INTRAVITREAL RANIBIZUMAB MONOTHERAPY Open
Purpose: To explore the clinical features and significance of “notch” in reactivation of retinopathy of prematurity (ROP) post–intravitreal ranibizumab (IVR) monotherapy. Methods: Ninety-six infants (173 eyes) with Type 1 or aggressive ROP…
View article: Single-cell resolution profiling of the immune microenvironment in primary and metastatic nasopharyngeal carcinoma
Single-cell resolution profiling of the immune microenvironment in primary and metastatic nasopharyngeal carcinoma Open
View article: [Comparison of initiation of antihypertensive therapy strategies for primary prevention of cardiovascular diseases in Chinese population: A decision-analytic Markov modelling study].
[Comparison of initiation of antihypertensive therapy strategies for primary prevention of cardiovascular diseases in Chinese population: A decision-analytic Markov modelling study]. Open
When initiating antihypertensive therapy in an economically developed area of China, the strategy combined with cardiovascular risk assessment is more efficient than those purely based on the SBP threshold. The cardiovascular risk assessme…
View article: Development of Coordinated Data-Acquisition Scheme for Minimizing Daylight Interference in Intelligent Lighting System
Development of Coordinated Data-Acquisition Scheme for Minimizing Daylight Interference in Intelligent Lighting System Open
View article: Cancer stem cells and their niche in cancer progression and therapy
Cancer stem cells and their niche in cancer progression and therapy Open
View article: Correction to: CXCL6: A potential therapeutic target for inflammation and cancer
Correction to: CXCL6: A potential therapeutic target for inflammation and cancer Open
View article: Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones—A systematic review
Light therapy for sleep disturbance comorbid depression in relation to neural circuits and interactive hormones—A systematic review Open
Aim To provide an overview of the evidence on the effect of light therapy on sleep disturbance and depression, identify the light-active neural and hormonal correlates of the effect of light therapy on sleep disturbance comorbid depression…
View article: Immuno-genomic-radiomics to predict response of biliary tract cancer to camrelizumab plus GEMOX in a single-arm phase II trial
Immuno-genomic-radiomics to predict response of biliary tract cancer to camrelizumab plus GEMOX in a single-arm phase II trial Open
Post hoc analysis of NCT03486678.
View article: Selective and Efficient Catalytic Oxygenation of Alkyl Aromatics Employing H2O2 Catalyzed by Simple Porphyrin Iron(II) under Mild Conditions
Selective and Efficient Catalytic Oxygenation of Alkyl Aromatics Employing H2O2 Catalyzed by Simple Porphyrin Iron(II) under Mild Conditions Open
The excessive utilization of additives in chemical reactions is a troublesome problem in industrial processes, due to their adverse effects on equipment and processes. To acquire oxidative functionalization of alkyl aromatics under additiv…
View article: Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy
Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy Open
A fundamental understanding of cancer-specific antigens is crucial for successful T-cell immunotherapy. Sarcoma antigen 1 (SAGE1) is a cancer/testis antigen that has not yet been verified for T-cell immunotherapy applications. Here, we exa…
View article: Supplementary Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy
Supplementary Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy Open
Fig. S1 shows the SAGE1 expression in NSCLC samples. Fig. S2 shows the PCR products visualized by gel electrophoresis. Fig. S3 shows the proportion of SAGE1597-606-HLA-A24 specific population before and after first stimulation in CD8+ T ce…
View article: Supplementary Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy
Supplementary Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy Open
Fig. S1 shows the SAGE1 expression in NSCLC samples. Fig. S2 shows the PCR products visualized by gel electrophoresis. Fig. S3 shows the proportion of SAGE1597-606-HLA-A24 specific population before and after first stimulation in CD8+ T ce…
View article: Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy
Data from SAGE1: a Potential Target Antigen for Lung Cancer T-Cell Immunotherapy Open
A fundamental understanding of cancer-specific antigens is crucial for successful T-cell immunotherapy. Sarcoma antigen 1 (SAGE1) is a cancer/testis antigen that has not yet been verified for T-cell immunotherapy applications. Here, we exa…
View article: Strategies to inTerrupt RAbies Transmission for the Elimination Goal by 2030 In China (STRATEGIC): a modelling study
Strategies to inTerrupt RAbies Transmission for the Elimination Goal by 2030 In China (STRATEGIC): a modelling study Open
View article: Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence
Multimodality neuroimaging in vascular mild cognitive impairment: A narrative review of current evidence Open
The vascular mild cognitive impairment (VaMCI) is generally accepted as the premonition stage of vascular dementia (VaD). However, most studies are focused mainly on VaD as a diagnosis in patients, thus neglecting the VaMCI stage. VaMCI st…
View article: Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity
Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity Open
The clinical success of T-cell receptor (TCR)-based immunotherapy depends on the efficacy and specificity of TCRs. Naturally occurring TCRs have limited anti-tumor potency due to their low affinity for tumor antigens. Affinity enhancement …