Qiuyan Guo
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View article: Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis
Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis Open
View article: Global research on the utilization of population pharmacokinetic model: a bibliometric analysis from 2000 to 2024
Global research on the utilization of population pharmacokinetic model: a bibliometric analysis from 2000 to 2024 Open
Objective Population pharmacokinetic (PPK) model is capable of identifying the factors that influence the variability of pharmacokinetic (PK) profiles and the degree of their influence, effectively reduces unexplained variability, and demo…
View article: The regulation of CgDM9CP-7 for maintaining the homeostasis of hemolymph microbiota in oyster Crassostrea gigas
The regulation of CgDM9CP-7 for maintaining the homeostasis of hemolymph microbiota in oyster Crassostrea gigas Open
View article: CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers
CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers Open
Driver CNV genes were identified to reveal the underlying cause of heterogeneity in DGC and IGC. Furthermore, specific driver CNV genes were identified as potential therapeutic targets, facilitating personalized treatment.
View article: Integrated UPLC-Q-TOF-MS, network pharmacology and experimental approach to evaluate the effects of blood stasis constitution ointment on lung cancer
Integrated UPLC-Q-TOF-MS, network pharmacology and experimental approach to evaluate the effects of blood stasis constitution ointment on lung cancer Open
Background Blood stasis constitution ointment (BSCO) is based on the classic formulas Xuefu Zhuyu and Buyang Huanwu decoctions described in Yilin Gaicuo by Wang Qingren of the Qing Dynasty. These formulas have been used to effectively trea…
View article: Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis
Effects of plant active substances in rheumatoid arthritis—a systematic review and network meta-analysis Open
Background Plant active substances are extensively utilized in treating rheumatoid arthritis (RA). Despite numerous experimental and clinical studies on plant active substances their efficacy remains largely unsubstantiated. The widespread…
View article: Tissue‐resident memory T cells in diseases and therapeutic strategies
Tissue‐resident memory T cells in diseases and therapeutic strategies Open
Tissue‐resident memory T (T RM ) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, T RM cells are located…
View article: MRdb: a comprehensive database of univariate and multivariate Mendelian randomization with large-scale GWAS summary data
MRdb: a comprehensive database of univariate and multivariate Mendelian randomization with large-scale GWAS summary data Open
Recent advancements highlight the importance of large-scale causal inference in elucidating disease mechanisms and guiding public health strategies. Mendelian randomization (MR) has become a cornerstone method for identifying causal relati…
View article: Microfluidic Fabrication of Peptide Modified Carrier-Free Self-Assembled Crizotinib-Metal Nanodrugs for Near-Infrared Imaging and Dual-Pathway Therapy of Non-Small Cell Lung Cancer
Microfluidic Fabrication of Peptide Modified Carrier-Free Self-Assembled Crizotinib-Metal Nanodrugs for Near-Infrared Imaging and Dual-Pathway Therapy of Non-Small Cell Lung Cancer Open
View article: LnCeCell 2.0: an updated resource for lncRNA-associated ceRNA networks and web tools based on single-cell and spatial transcriptomics sequencing data
LnCeCell 2.0: an updated resource for lncRNA-associated ceRNA networks and web tools based on single-cell and spatial transcriptomics sequencing data Open
We describe LnCeCell 2.0 (http://bio-bigdata.hrbmu.edu.cn/LnCeCell), an updated resource for lncRNA-associated competing endogenous RNA (ceRNA) networks and web tools based on single-cell and spatial transcriptomics sequencing (stRNA-seq) …
View article: <i>Cordyceps sinensis</i> ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress
<i>Cordyceps sinensis</i> ameliorates idiopathic pulmonary fibrosis in mice via inhibiting mitochondrion‐mediated oxidative stress Open
Idiopathic pulmonary fibrosis (IPF) represents a chronic interstitial lung disease with an unclear underlying mechanism and currently lacks a definitive treatment. Cordyceps sinensis (CS), renowned for its pharmacological properties in tra…
View article: Correction: Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma
Correction: Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma Open
View article: Application of carrier free nanomaterials in healthcare
Application of carrier free nanomaterials in healthcare Open
Nanodrugs offer a means of delivering drugs that can enhance their bioavailability. However, the practical application of nanomedicines is hindered by the use of carrier materials in their construction, which can make them potentially toxi…
View article: Ferroptosis: A double-edged sword
Ferroptosis: A double-edged sword Open
View article: The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases
The biomedical application of inorganic metal nanoparticles in aging and aging-associated diseases Open
View article: Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway Open
View article: Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis
Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis Open
Glycyrrhetinic acid (GA) shows great efficiency against non-small cell lung cancer (NSCLC), but the detailed mechanism is unclear, which has limited its clinical application. Herein, we investigated the potential targets of GA against NSCL…
View article: Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism
Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism Open
This study demonstrated that BBR exerts a protective effect on acute gastric ulcer by promoting tricarboxylic acid cycle-mediated arachidonic acid metabolism.
View article: Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and macrophage polarization
Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and macrophage polarization Open
Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional medicine for the prevention, treatment, and prognostication of various diseases, because of its pleiotropic pharmacological properties. However, the potent…
View article: Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma
Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma Open
View article: Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy
Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy Open
Sorafenib is the most widely used first-line drug for the treatment of the advanced hepatocellular carcinoma (HCC). Unfortunately, sorafenib resistance often limits its therapeutic efficacy. To evaluate the efficacy of artesunate against s…
View article: METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing Open
Background Endometriosis (EMs), the ectopic planting of functional endometrium outside of the uterus, is a leading cause of infertility and pelvic pain. As a fundamental mRNA modification, N6-methyladenosine (m6A) participates in various p…
View article: Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation
Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation Open
Rheumatoid arthritis (RA) is characterized by bone destruction in the afflicted joints, and during the process of bone destruction, osteoclasts play a crucial role. Tanshinone IIA (Tan IIA) has shown anti-inflammatory effects in RA. Howeve…
View article: Research progress on pharmacological actions and molecular mechanisms of Anemoside B4
Research progress on pharmacological actions and molecular mechanisms of Anemoside B4 Open
Anemoside B4 (AB4), as an important ingredient of Chinese herb Pulsatilla Chinensis, has been used in Chinese ancient medicine for thousands of years with exact therapeutic effects of anti-inflammation and anti-tumor. Due to its high poten…
View article: Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice
Single-cell transcriptome analysis uncovers underlying mechanisms of acute liver injury induced by tripterygium glycosides tablet in mice Open
View article: Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis Open
View article: Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy
Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy Open
Cancer has been considered as complex malignant consequence of genetic mutations that control the cellular proliferation, differentiation and homeostasis, thus making tumor treatment extremely challenging. To date, a variety of cargo molec…
View article: Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery
Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery Open
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradatio…
View article: Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss
Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss Open
View article: Preparation and application of calcium phosphate nanocarriers in drug delivery
Preparation and application of calcium phosphate nanocarriers in drug delivery Open