Qin Chen
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View article: MSC-encapsulated porous microparticle eye drops for autoimmune dry eye disease treatment in NOD mice
MSC-encapsulated porous microparticle eye drops for autoimmune dry eye disease treatment in NOD mice Open
Dry eye disease (DED) is characterized by chronic inflammation and an unstable tear film. Stem cells have shown potential for DED treatment, but the main challenge lies in improving cell delivery effectiveness. Here, we developed eye drops…
View article: Evaluating Psychological Competency via Chinese Q&A in Large Language Models
Evaluating Psychological Competency via Chinese Q&A in Large Language Models Open
Recently, the application of large language models (LLMs) in psychology has gained increasing attention. However, their psychological competence still requires further investigation. This study explores this issue through the lens of Chine…
View article: Diagnosis models to predict peripheral arterial disease: a systematic review and meta analysis
Diagnosis models to predict peripheral arterial disease: a systematic review and meta analysis Open
View article: Prevalence of Tuberculosis among migrants under national screening programs: a systematic review and meta-analysis
Prevalence of Tuberculosis among migrants under national screening programs: a systematic review and meta-analysis Open
View article: LINC02593 impedes cell senescence via COP1-mediated p53 degradation in cervical cancer
LINC02593 impedes cell senescence via COP1-mediated p53 degradation in cervical cancer Open
Evasion of cellular senescence is one of the hallmarks of cervical carcinoma (CC) to maintain malignant development. Even though the regulators driving CC cell senescence are widely recognized, the underlying upstream mechanisms are still …
View article: Deciphering the Threshold and Segmented Nonlinear Association Between Systemic Inflammation Response Index and Spinal Bone Density: Insights From a Large-Scale Population Study
Deciphering the Threshold and Segmented Nonlinear Association Between Systemic Inflammation Response Index and Spinal Bone Density: Insights From a Large-Scale Population Study Open
Study Design Cross-sectional study. Objective To examine the association between SIRI and spinal BMD and assess the influence of age, hypertension, and diabetes. Methods We analyzed data from 13,950 participants aged ≥20 years. SIRI was ca…
View article: CL-MoE: Enhancing Multimodal Large Language Model with Dual Momentum Mixture-of-Experts for Continual Visual Question Answering
CL-MoE: Enhancing Multimodal Large Language Model with Dual Momentum Mixture-of-Experts for Continual Visual Question Answering Open
Multimodal large language models (MLLMs) have garnered widespread attention from researchers due to their remarkable understanding and generation capabilities in visual language tasks (e.g., visual question answering). However, the rapid p…
View article: Wnt/β-catenin signaling pathway: an attractive potential therapeutic target in osteosarcoma
Wnt/β-catenin signaling pathway: an attractive potential therapeutic target in osteosarcoma Open
Osteosarcoma (OS) is the most common bone malignancy in children and adolescents, and although current neoadjuvant chemotherapy has shown efficacy against OS, the long-term survival rate for patients with OS remains low, highlighting the n…
View article: Prevalence and Prognostic Significance of Sarcopenia in Gynecologic Oncology: A Systematic Review and Meta‐Analysis
Prevalence and Prognostic Significance of Sarcopenia in Gynecologic Oncology: A Systematic Review and Meta‐Analysis Open
Background Sarcopenia in gynaecologic oncology patients has garnered increasing attention, but its prevalence has not been comprehensively summarized. This study aims to integrate the prevalence of sarcopenia in this population through sys…
View article: Is Self-management associated with the Risk of Adverse Outcomes in Patients with Lower Extremity Arterial Disease Who Underwent Endovascular Revascularization? A Prospective Longitudinal Observational Study
Is Self-management associated with the Risk of Adverse Outcomes in Patients with Lower Extremity Arterial Disease Who Underwent Endovascular Revascularization? A Prospective Longitudinal Observational Study Open
View article: Natural Compound Emodin Protects Against Mptp Neurotoxicity Via P53-Ferroptosis Inhibition
Natural Compound Emodin Protects Against Mptp Neurotoxicity Via P53-Ferroptosis Inhibition Open
View article: The Association Between D-Dimer Levels and Recurrence in Patients with Early-Stage Cervical Cancer after Surgical Treatment
The Association Between D-Dimer Levels and Recurrence in Patients with Early-Stage Cervical Cancer after Surgical Treatment Open
High levels of D-dimer were associated with increased recurrence risk of CC in patients at the early stage of surgical treatment.
View article: Different peripheral nerve blocks for patients undergoing total knee arthroplasty: a network meta-analysis of randomized controlled trials
Different peripheral nerve blocks for patients undergoing total knee arthroplasty: a network meta-analysis of randomized controlled trials Open
cACB combined with IPACK/GNB may be the most favorable block after TKA, continuous blocks may be better than single-shot blocks, and combined blocks may be better than separate blocks.
View article: Selenium supplementation elevated SELENBP1 to inhibit fibroblast activation in pulmonary arterial hypertension
Selenium supplementation elevated SELENBP1 to inhibit fibroblast activation in pulmonary arterial hypertension Open
Pulmonary arterial hypertension (PAH) is a life-threatening disease induced by abnormal activation of pulmonary adventitial fibroblasts (PAFs) in the early stage. The association between selenium deficiency and PAH is not yet fully underst…
View article: CT morphological features and histogram parameters to predict micropapillary or solid components in stage IA lung adenocarcinoma
CT morphological features and histogram parameters to predict micropapillary or solid components in stage IA lung adenocarcinoma Open
Objectives This study aimed to construct prediction models based on computerized tomography (CT) signs, histogram and morphology features for the diagnosis of micropapillary or solid (MIP/SOL) components of stage IA lung adenocarcinoma (LU…
View article: Frontier and hot topics in home enteral nutrition based on CiteSpace bibliometric analysis
Frontier and hot topics in home enteral nutrition based on CiteSpace bibliometric analysis Open
Background The benefits of home enteral nutrition (HEN) are increasingly recognized, with more scholars focusing on this field. This study aimed to comprehensively identify collaborative networks, analyze, and track research trends, focus …
View article: Enhancing Event Causality Identification with Rationale and Structure-Aware Causal Question Answering
Enhancing Event Causality Identification with Rationale and Structure-Aware Causal Question Answering Open
Document-level Event Causality Identification (DECI) aims to identify causal relations between two events in documents. Recent research tends to use pre-trained language models to generate the event causal relations. Whereas, these methods…
View article: Two case reports: EML4-ALK rearrangement large cell neuroendocrine carcinoma and literature review
Two case reports: EML4-ALK rearrangement large cell neuroendocrine carcinoma and literature review Open
Anaplastic lymphoma kinase gene (ALK) rearrangement is present in only approximately 5% of non-small cell lung cancers (NSCLCs) and is scarce in LCNEC patients. The conventional first-line treatment options are chemotherapy combined with i…
View article: NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification
NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification Open
View article: An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD
An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD Open
Sustained retina drug delivery and rational drug combination are considered essential for enhancing the efficacy of therapy for wet age-related macular degeneration (wAMD) due to the conservative structure of the posterior ocular segment a…
View article: Table of Contents
Table of Contents Open
View article: Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention
Rapid and Economical Drug-Eluting IOL Preparation via Thermoresponsive Agarose Coating for Effective Posterior Capsular Opacification Prevention Open
Posterior capsular opacification (PCO), the highest incidence complication after cataract surgery, is mainly due to the attachment, proliferation, and migration of the residual lens epithelial cells (LECs). Although the drug-eluting IOLs h…
View article: Imaging of the Pancreas in New-Onset Diabetes: A Prospective Pilot Study
Imaging of the Pancreas in New-Onset Diabetes: A Prospective Pilot Study Open
INTRODUCTION: The aim of this study was to assess the feasibility of cross-sectional imaging for detection of pancreatic cancer (PDAC) in patients with new-onset hyperglycemia and diabetes (NOD). METHODS: We conducted a prospective pilot s…
View article: Correction: Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer
Correction: Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers
Highly parallel and efficient single cell mRNA sequencing with paired picoliter chambers Open
ScRNA-seq has the ability to reveal accurate and precise cell types and states. Existing scRNA-seq platforms utilize bead-based technologies uniquely barcoding individual cells, facing practical challenges for precious samples with limited…
View article: LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating <i>PLCD3</i> Expression
LncRNA PLCD3-OT1 Functions as a CeRNA to Prevent Age-Related Cataract by Sponging miR-224-5p and Regulating <i>PLCD3</i> Expression Open
PLCD3-OT1 and PLCD3 may become potential therapeutic targets for the prognosis, diagnosis, and treatment of ARC.
View article: <p>Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification</p>
Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification Open
These findings suggested that such multifunctionalized drug-eluting IOLs can effectively reduce the posterior hyperplasia and SR formation when intraocular implantation has a major impact on reducing PCO incidence. Thus they have a great p…
View article: 356 Minocycline inhibits keratinocyte proliferation via modulating Ca2+/lysosome/IL1α system
356 Minocycline inhibits keratinocyte proliferation via modulating Ca2+/lysosome/IL1α system Open
View article: Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation Open
Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activatio…
View article: Table of Contents
Table of Contents Open