Qiyong Huai
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View article: Design, synthesis and antitumor activity of triphenylphosphonium-linked derivatives of quinazolinone
Design, synthesis and antitumor activity of triphenylphosphonium-linked derivatives of quinazolinone Open
Cancer is the leading cause of human death. Quinazolinone heterocyclic compounds have a variety of biological activities and have been extensively studied in recent years, especially for their potential anticancer activity. The triphenylph…
View article: Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups Open
View article: Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
Antiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups Open
View article: Design, Preparation and Studies Regarding Cytotoxic Properties of Glycyrrhetinic Acid Derivatives
Design, Preparation and Studies Regarding Cytotoxic Properties of Glycyrrhetinic Acid Derivatives Open
Glycyrrhetinic acid (GA) is a natural product with certain antitumor activity. In order to enhance the cytotoxicity, a total of eighteen derivatives of GA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human bre…
View article: Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties
Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties Open
View article: Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties Open
The screening results showed that the compound 3m presented the highest inhibitory activities against SGC-7901, MCF-7 and Eca-109 cell lines with IC50 values of 7.57±0.64 μM, 5.51±0.41 μM and 5.03±0.56 μM, respectively. I…
View article: Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids
Design and Synthesis of New Anticancer Glycyrrhetinic Acids and Oleanolic Acids Open
A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-…
View article: Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives Open
A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. …
View article: Synthesis and Evaluation of Antibacterial and Antitumor Activities of Apigenin Derivatives
Synthesis and Evaluation of Antibacterial and Antitumor Activities of Apigenin Derivatives Open
View article: Synthesis and Biological Evaluation of Curcuminoid Derivatives
Synthesis and Biological Evaluation of Curcuminoid Derivatives Open
Many curcuminoid derivatives have been reported to have multiple biological activities. The aim of this study was to improve the biological activity of curcuminoids by synthesizing 16 new derivatives which combined cinnamic acids with curc…