Qi Fu
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View article: Association between triglyceride-glucose index and early vascular aging in patients with type 2 diabetes mellitus: a retrospective cross-sectional study
Association between triglyceride-glucose index and early vascular aging in patients with type 2 diabetes mellitus: a retrospective cross-sectional study Open
A higher TyG index and elevated systolic blood pressure were independently associated with the presence of EVA, whereas male sex and the absence of T2DM complications were associated with a lower likelihood of its occurrence. These finding…
View article: An interpretable machine learning model integrating computed tomography radiomics and clinical features for predicting the urosepsis after percutaneous nephrolithotomy
An interpretable machine learning model integrating computed tomography radiomics and clinical features for predicting the urosepsis after percutaneous nephrolithotomy Open
View article: Pharmacokinetics and bioequivalence of oseltamivir suspension in healthy Chinese subjects
Pharmacokinetics and bioequivalence of oseltamivir suspension in healthy Chinese subjects Open
Objective This study was conducted to evaluate the bioequivalence, pharmacokinetic profiles, and safety of a generic oseltamivir suspension compared with the branded reference product (Tamiflu®) under both fasting and fed conditions in hea…
View article: Assessment of Pharmacokinetics and Safety with Bioequivalence of the Nitroglycerin Sublingual Tablets of Two Formulations in Chinese Healthy Subjects: A Bioequivalence Study
Assessment of Pharmacokinetics and Safety with Bioequivalence of the Nitroglycerin Sublingual Tablets of Two Formulations in Chinese Healthy Subjects: A Bioequivalence Study Open
The study confirmed bioequivalence between the test and reference formulations, demonstrating equivalent absorption rates (Cmax) and extents (AUC). Rapid therapeutic plasma levels were achieved via sublingual administration, ali…
View article: Study on the effect of environmental humidity on the thermal decomposition characteristics of PVC outer sheath of high-voltage cables
Study on the effect of environmental humidity on the thermal decomposition characteristics of PVC outer sheath of high-voltage cables Open
With the continuous expansion of the city’s high-voltage cable commissioning scale, cable failure caused by electrical fires is increasingly serious problem. As a critical insulating component, the thermal decomposition characteristics of …
View article: Bidirectional mendelian randomization assessment of causality between lactate levels and multiple autoimmune diseases
Bidirectional mendelian randomization assessment of causality between lactate levels and multiple autoimmune diseases Open
View article: Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population
Cumulative blood pressure predicts risk of cardiovascular outcomes in middle-aged and older population Open
Long-term cSBP, cDBP and cMAP were associated with subsequent CVD and only found in people younger than 60 years of age, whereas cPP was associated with stroke only across all ages. Cumulative BP may provide a better prediction of cardiova…
View article: The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects
The MTNR1B Rs724030 variant is associated with islet function and women waist-to-hip ratio in healthy subjects Open
Objective This study aims to investigate the associations between MTNR1B rs724030 A>G variant and prediabetes risk, along with their correlations with clinical features, including plasma glucose and serum insulin levels during oral gluc…
View article: Integrating Deep Learning–Derived Whole-Body PET Metabolic Features with R-ISS to Improve Prognostic Prediction in Multiple Myeloma
Integrating Deep Learning–Derived Whole-Body PET Metabolic Features with R-ISS to Improve Prognostic Prediction in Multiple Myeloma Open
View article: Supplementation and Mitigating Cognitive Decline in Older Adults With or Without Mild Cognitive Impairment or Dementia: A Systematic Review
Supplementation and Mitigating Cognitive Decline in Older Adults With or Without Mild Cognitive Impairment or Dementia: A Systematic Review Open
This systematic literature review aims to answer the question of how micronutrients might influence the development and progression of dementia. In the present work, we focused on an overview of an updated review of relevant literature pub…
View article: Long-Term Cumulative Depressive Symptoms and Incident Cardiovascular Disease in Middle-Aged and Older Population: Two Cohort Studies
Long-Term Cumulative Depressive Symptoms and Incident Cardiovascular Disease in Middle-Aged and Older Population: Two Cohort Studies Open
View article: Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults - China, 2002-2018.
Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults - China, 2002-2018. Open
The results of the study corroborate the relationship between the augmented consumption frequency of meat, fruit, bean products, garlic, and tea, in conjunction with an elevated DDS, and an increased risk of developing cognitive frailty.
View article: Adverse Maternal Environments Perturb Hepatic DNA Methylome and Transcriptome Prior to the Adult-Onset Non-Alcoholic Fatty Liver Disease in Mouse Offspring
Adverse Maternal Environments Perturb Hepatic DNA Methylome and Transcriptome Prior to the Adult-Onset Non-Alcoholic Fatty Liver Disease in Mouse Offspring Open
Exposure to adverse early-life environments (AME) increases the incidence of developing adult-onset non-alcoholic fatty liver disease (NAFLD). DNA methylation has been postulated to link AME and late-onset diseases. This study aimed to inv…
View article: The coverage of SARS-CoV-2 vaccination and the willingness to receive the SARS-CoV-2 variant vaccine among employees in China
The coverage of SARS-CoV-2 vaccination and the willingness to receive the SARS-CoV-2 variant vaccine among employees in China Open
View article: Analysis of radiotherapy impact on survival in resected stage I/II pancreatic cancer patients: a population-based study
Analysis of radiotherapy impact on survival in resected stage I/II pancreatic cancer patients: a population-based study Open
Background: The application of radiotherapy (RT) in pancreatic cancer remains controversial. Aim: The aim of the study was to evaluate the efficacy of radiotherapy (neoadjuvant and adjuvant radiotherapy) for resectable I/II pancreatic canc…
View article: A novel numerical model of combination levels of C-peptide and insulin in coronary artery disease risk prediction
A novel numerical model of combination levels of C-peptide and insulin in coronary artery disease risk prediction Open
ObjectiveInsulin resistance is a major risk factor for coronary artery disease (CAD). The C-peptide-to-insulin ratio (C/I) is associated with hepatic insulin clearance and insulin resistance. The current study was designed to establish a …
View article: Analysis of Radiotherapy Impact on Survival in Resected Stage I/ii Pancreatic Cancer Patients: A Population-based Study
Analysis of Radiotherapy Impact on Survival in Resected Stage I/ii Pancreatic Cancer Patients: A Population-based Study Open
Background: The application of radiotherapy (RT) in pancreatic cancer remains controversial. The aim of the study was to evaluate the efficacy of radiotherapy (neoadjuvant and adjuvant radiotherapy) for resectable I/II pancreatic cancer. M…
View article: Urinary C-Peptide Secretion(UCPS): Can It be A New Index to Reflect Insulin Sensitivity and A Predictor in Pregnant Women?
Urinary C-Peptide Secretion(UCPS): Can It be A New Index to Reflect Insulin Sensitivity and A Predictor in Pregnant Women? Open
Background: In order to assess the correlation between pregnant women's urinary C-peptide secretion(UCPS) and insulin sensitivity, and to examine the predictors of gestational diabetes. Methods: we recruited 166 women between 20 and 28 wee…
View article: Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice
Adverse maternal environment and western diet impairs cognitive function and alters hippocampal glucocorticoid receptor promoter methylation in male mice Open
Adverse maternal environment (AME) and high-fat diet in early childhood increase the risk of cognitive impairment and depression later in life. Cognitive impairment associates with hippocampal dysfunction. A key regulator of hippocampal fu…
View article: Impaired β-cell function and decreased insulin sensitivity in subjects with normal oral glucose tolerance but isolated high glycosylated hemoglobin
Impaired β-cell function and decreased insulin sensitivity in subjects with normal oral glucose tolerance but isolated high glycosylated hemoglobin Open
The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aime…
View article: Matsuda ISI (mean ± s.e.) and HOMA-IR (mean ± s.e.) according to visceral adiposity index quartiles after adjustments for sex and age.
Matsuda ISI (mean ± s.e.) and HOMA-IR (mean ± s.e.) according to visceral adiposity index quartiles after adjustments for sex and age. Open
* P<0.001 for the comparison to the first quartile. Matsuda ISI, Matsuda Insulin Sensitivity Index; HOMA-IR, homeostasis model assessment of insulin resistance.
View article: Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury
Effect of low temperatures on BAX and BCL2 proteins in rats with spinal cord ischemia reperfusion injury Open
We evaluated changes in BAX and BCL2 expression levels after spinal cord ischemia/reperfusion injury (SCII) and hypothermia during operations in rats. Eighty rats were divided into four groups: Group A (N = 20, 18°C); Group B (N = 20, 28°C…
View article: The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and <b><i>β</i></b>-Cell Function in Newly Diagnosed Type 2 Diabetes
The Relationship between Serum 25-Hydroxy Vitamin D and Insulin Sensitivity and <b><i>β</i></b>-Cell Function in Newly Diagnosed Type 2 Diabetes Open
The aim of this study was to investigate the relationship between serum 25-hydroxy vitamin D (25-OHD) and insulin sensitivity and β -cell function in newly diagnosed type 2 diabetes. 395 newly diagnosed type 2 diabetes patients were enroll…