Qosay Al‐Balas
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View article: Cytotoxic, anti-inflammatory, antioxidant, and anti-glyoxalase-I evaluation of chelating substances: In silico and in vitro study
Cytotoxic, anti-inflammatory, antioxidant, and anti-glyoxalase-I evaluation of chelating substances: In silico and in vitro study Open
Introduction Glyoxalase I is a crucial target in cancer treatment due to its involvement in detoxifying methylglyoxal. Suppressing the activity of Glyoxalase I has great potential for disrupting the pathways that allow cancer cells to surv…
View article: A Traditional Gum Exudate From <scp><i>Pistacia atlantica</i></scp> Ameliorates Etha‐Nol‐Mediated Gastric Ulcer in Rats: Possible Molecular Mechanisms
A Traditional Gum Exudate From <span><i>Pistacia atlantica</i></span> Ameliorates Etha‐Nol‐Mediated Gastric Ulcer in Rats: Possible Molecular Mechanisms Open
Pistacia atlantica (Bene) is a native Mediterranean plant that exudates a resinous therapeutic oleoresin gum used for many inflammatory‐related diseases. Therefore, the present study evaluates the acute toxicity and the gastroprotective ef…
View article: Synthesis, molecular docking, and <i>in vitro</i> activity of a novel angiotensin-converting enzyme 2 inhibitor, LMS1007: a potential molecule in Covid-19 and cancer treatments
Synthesis, molecular docking, and <i>in vitro</i> activity of a novel angiotensin-converting enzyme 2 inhibitor, LMS1007: a potential molecule in Covid-19 and cancer treatments Open
Angiotensin-converting enzyme 2 (ACE2) is a validated common protein in the pathology of several diseases, including novel coronavirus and breast cancer.
View article: Design, Synthesis and Biological Evaluation of Potent Thiazolidinedione Salicylic Acid Inhibitors Against Glyoxalase-I as Potential Anticancer Agents
Design, Synthesis and Biological Evaluation of Potent Thiazolidinedione Salicylic Acid Inhibitors Against Glyoxalase-I as Potential Anticancer Agents Open
The worldwide rise in cancer incidence and mortality rates has spurred the search for new pathways implicated in cancer development and progression. One such target is glyoxalase 1 (GLO-I), a key player in methylglyoxal detoxification and …
View article: Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques
Unraveling Potential Glyoxalase-I Inhibitors Utilizing Structure-Based Drug Design Techniques Open
Two hits with moderate activity are identified as the lead compounds against Glo-I. Both compounds possess a negatively ionized tetrazole ring as the zinc-binding moiety. These compounds will lead to the development of inhibitors with impr…
View article: Computational fragment-based drug design of potential Glo-I inhibitors
Computational fragment-based drug design of potential Glo-I inhibitors Open
In this study, a fragment-based drug design approach, particularly de novo drug design, was implemented utilising three different crystal structures in order to discover new privileged scaffolds against glyoxalase-I enzyme as anticancer ag…
View article: Novel anthraquinone amide derivatives as potential Glyoxalase-I inhibitors
Novel anthraquinone amide derivatives as potential Glyoxalase-I inhibitors Open
This study aimed to identify novel Glyoxalase-I (Glo-I) inhibitors with potential anticancer properties, focusing on anthraquinone amide-based derivatives. We synthesized a series of these derivatives and conducted in silico docking studie…
View article: Integrating ligand and structure-based discovery approaches to unravel potential novel glyoxalase-I inhibitors
Integrating ligand and structure-based discovery approaches to unravel potential novel glyoxalase-I inhibitors Open
The early 1900s discovery of the glyoxalase system revealed its numerous biological functions, including cancer. The conversion of harmful ketoaldehydes like methylglyoxal into nontoxic metabolites by this mechanism is crucial. Cells maint…
View article: Computational fragment-based drug design of potential Glo-I inhibitors
Computational fragment-based drug design of potential Glo-I inhibitors Open
In this study, a fragment-based drug design approach, particularly de novo drug design, was implemented utilising three different crystal structures in order to discover new privileged scaffolds against glyoxalase-I enzyme as anticancer ag…
View article: Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits
Islamic Perspectives on Polygenic Testing and Selection of IVF Embryos (PGT-P) for Optimal Intelligence and Other Non–Disease-Related Socially Desirable Traits Open
In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more r…
View article: The practice of defensive medicine among Jordanian physicians: A cross sectional study
The practice of defensive medicine among Jordanian physicians: A cross sectional study Open
Background Defensive medicine (DM) is a deviation from medical practice that is induced primarily by a threat of liability. While the DM behavior is well studied in the developed countries, little is known in developing countries and never…
View article: Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study
Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study Open
Manzamines are chemically related compounds extracted from the methanolic extract of Acanthostrongylophora ingens species. Seven compounds were identified by our research group and are being characterized. As their biological target is unk…
View article: Computational medicinal chemistry role in clinical pharmacy education: Ingavirin for coronavirus disease 2019 (COVID-19) discovery model
Computational medicinal chemistry role in clinical pharmacy education: Ingavirin for coronavirus disease 2019 (COVID-19) discovery model Open
Ingavirin has a promising inhibitory potential to host (ACE2 and nCoV spike protein) recognition, and hence could offer the next best mitigating effect against the current coronavirus disease (COVID-19) pandemic.
View article: Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors
Design, Synthesis and Biological Evaluation of 1,4-Benzenesulfonamide Derivatives as Glyoxalase I Inhibitors Open
Suaad Abdallah Audat,1 Qosay Ali Al-Balas,2 Buthina Abdallah Al-Oudat,2 Mo’ad Jamil Athamneh,1 Amanda Bryant-Friedrich3 1Department of Chemistry, College of Science and Arts, Jordan University of Science and Technology, Irbid, 22110, Jorda…
View article: Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein
Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein Open
Aims: Angiotensin-converting enzyme 2 (ACE2) plays an important role in the entry of coronaviruses into host cells. The current paper described how carnosine, a naturally occurring supplement, can be an effective drug candidate for coronav…
View article: Carnosine to Combat Novel Coronavirus (nCoV, COVID-19): Molecular Docking and Modeling to Co-Crystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein
Carnosine to Combat Novel Coronavirus (nCoV, COVID-19): Molecular Docking and Modeling to Co-Crystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein Open
Aims: Angiotensin-converting enzyme 2 (ACE2) plays an important role in the entry of coronaviruses into host cells. This paper described how carnosine, a naturally occurring supplement, can be an effective drug candidate for coronavirus di…
View article: Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold
Ellagic acid: A potent glyoxalase-I inhibitor with a unique scaffold Open
The glyoxalase system, particularly glyoxalase-I (GLO-I), has been approved as a potential target for cancer treatment. In this study, a set of structurally diverse polyphenolic natural compounds were investigated as potential GLO-I inhibi…
View article: Anti-Helicobacter activity of medicinal plants and probiotics as alternatives for Helicobacter pylori treatment: Review article
Anti-Helicobacter activity of medicinal plants and probiotics as alternatives for Helicobacter pylori treatment: Review article Open
Helicobacter pylori, a gram-negative bacterium, known factor for chronic active gastritis, stomach and peptic ulceration, which may progress to gastric cancer. It is also associated with other non-gastric diseases such as stroke, diabetes …
View article: Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking
Identification of Human Leukotriene A4 Hydrolase Inhibitors Using Structure-Based Pharmacophore Modeling and Molecular Docking Open
Leukotriene B4 (LTB4) is a potent, proinflammatory lipid mediator implicated in the pathologies of an array of inflammatory diseases and cancer. The biosynthesis of LTB4 is regulated by the leukotriene A4 hydrolase (LTA4H). Compounds capab…
View article: Discovery of Novel Glyoxalase-I Inhibitors Using Computational Fragment-Based Drug Design Approach
Discovery of Novel Glyoxalase-I Inhibitors Using Computational Fragment-Based Drug Design Approach Open
أستخدم في هذه الدراسة نهج تصميم الدواء المعتمد على المركبات الكيميائية الصغيرة، لتصميم مثبطات محتملة لأنزيم الجلايوكسيليز-1. يحدث فرط في إنتاج هذا الانزيم في أنواع مختلفة من السرطان، مما جعله هدفا عمليا لعلاج السرطان. استند النهج الحالي إل…
View article: Ethics of Biotechnology in relation to prevention of malaria through gene editing: An Islamic Perspective
Ethics of Biotechnology in relation to prevention of malaria through gene editing: An Islamic Perspective Open
TPS 723: Low and middle income countries: sanitation infections and other health effects, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Abstract: Background/Aim: Gene editing of mosquitos and other biotechnological adva…
View article: Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors
Multi-Armed 1,2,3-Selenadiazole and 1,2,3-Thiadiazole Benzene Derivatives as Novel Glyoxalase-I Inhibitors Open
Glyoxalase-I (Glo-I) enzyme was established to be a valid target for anticancer drug design. It performs the essential detoxification step of harmful byproducts, especially methylglyoxal. A robust computer-aided drug design approach was us…
View article: <p>Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators</p>
Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators Open
Our results show that the newly designed chrysin derivatives exert anticancer activity in human breast cancer cell lines, MDA-MB-231 and MCF-7. Therefore, they can be considered as leads for further development of more potent and selective…
View article: In vivo antimicrobial activity of the hybrid peptide H4: a follow-up study
In vivo antimicrobial activity of the hybrid peptide H4: a follow-up study Open
H4 is a novel hybrid peptide with great potential for antimicrobial drug development.
View article: A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria
A3, a Scorpion Venom Derived Peptide Analogue with Potent Antimicrobial and Potential Antibiofilm Activity against Clinical Isolates of Multi-Drug Resistant Gram Positive Bacteria Open
Current research in the field of antimicrobials is focused on developing novel antimicrobial agents to counteract the huge dilemma that the human population is mainly facing in regards to the rise of bacterial resistance and biofilm infect…
View article: Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides
Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides Open
Overall, this study indicates the success of both the hybridization and synergism strategy in developing AMPs as potential antimicrobial therapeutics with reduced toxicity profiles that could be efficiently employed to eradicate resistant …