Wenquan Wang
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View article: Genomic-Wide Association Markers and Candidate Genes for the High-Protein Trait in Storage Roots of Cassava (Manihot esculenta)
Genomic-Wide Association Markers and Candidate Genes for the High-Protein Trait in Storage Roots of Cassava (Manihot esculenta) Open
Cassava (Manihot esculenta Crantz) is a globally important staple crop. Although its leaves are rich in crude protein, the protein content in its storage roots is typically less than 2%, which limits its nutritional value. Exploring high-p…
View article: The Reference Genome Sequence of the Scarlet Follicle, Sterculia lanceolata, reveals a paleo-polyploidization and its impact on fruit quality and fruit dehiscence
The Reference Genome Sequence of the Scarlet Follicle, Sterculia lanceolata, reveals a paleo-polyploidization and its impact on fruit quality and fruit dehiscence Open
Sterculia lanceolata, a tree species of the Malvaceae family with notable ornamental and medicinal value, has long been constrained in genetic research and breeding applications due to the lack of genomic resources. In this study, we repor…
View article: Supervising the recurrence of pancreatic ductal adenocarcinoma using CtDNA-based MIR129-2 methylation detection
Supervising the recurrence of pancreatic ductal adenocarcinoma using CtDNA-based MIR129-2 methylation detection Open
Background: Surgery remains the primary treatment for pancreatic ductal adenocarcinoma (PDAC), which has remarkably high morbidity and mortality rates. However, recurrence is prevalent after resection. The effectiveness of circulating tumo…
View article: Impact of external drainage of the main pancreatic duct and common bile duct on postoperative pancreatic fistula following pancreatoduodenectomy: protocol for a multicentre randomized clinical trial
Impact of external drainage of the main pancreatic duct and common bile duct on postoperative pancreatic fistula following pancreatoduodenectomy: protocol for a multicentre randomized clinical trial Open
Background According to a retrospective study at Zhongshan Hospital, external drainage of the main pancreatic duct (MPD) and common bile duct (CBD) is potentially superior over internal drainage. As yet there is no consensus regarding the …
View article: CassavaDB: An integrated multi-omics resource for functional genomics and molecular breeding of cassava
CassavaDB: An integrated multi-omics resource for functional genomics and molecular breeding of cassava Open
View article: Intratumoral IL-33+CD4+FoxP3+ regulatory T cell infiltration determines poor clinical outcomes and intensive immunoevasive contexture in patients with pancreatic cancer after surgical resection: a cohort study
Intratumoral IL-33+CD4+FoxP3+ regulatory T cell infiltration determines poor clinical outcomes and intensive immunoevasive contexture in patients with pancreatic cancer after surgical resection: a cohort study Open
Background: Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is constitutively expressed in barrier cells such as endothelial cells and fibroblasts. While the expression of IL-33 in regulatory T cells (Tregs) has been previous…
View article: GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing
GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencing Open
View article: Improving gene editing of CRISPR/Cas9 using the callus-specific promoter pYCE1 in cassava (Manihot esculenta Crantz)
Improving gene editing of CRISPR/Cas9 using the callus-specific promoter pYCE1 in cassava (Manihot esculenta Crantz) Open
Previous studies have demonstrated that an appropriate promoter can drive Cas9 transcription in the CRISPR/Cas9 system, which improves the efficiency of gene editing. Here, we identified and characterized callus-specific promoters to enhan…
View article: Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis
Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis Open
In summary, AtNRT2.4 plays a crucial role in local and systemic nitrate signals sensing, adjustment of root architecture, and anthocyanin accumulation, providing new insights into how plants respond to nitrogen deprivation.
View article: Transcriptome and metabolome analysis reveals the mechanism of key nutrient formation in Hainan oil-camellia (Camellia hainanica) growth cycle
Transcriptome and metabolome analysis reveals the mechanism of key nutrient formation in Hainan oil-camellia (Camellia hainanica) growth cycle Open
View article: Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits
Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits Open
View article: A C-Terminally Encoded Peptide, MeCEP6, Promotes Nitrate Uptake in Cassava Roots
A C-Terminally Encoded Peptide, MeCEP6, Promotes Nitrate Uptake in Cassava Roots Open
Cassava, an essential food crop, is valued for its tolerance to infertile soils. This study explores the role of C-terminally encoded peptides (CEPs) in cassava, mainly focusing on MeCEP6 and its function in nitrate uptake and plant growth…
View article: Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges
Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges Open
View article: Identification of the cassava NADP-ME gene family and its response and regulation in photosynthesis
Identification of the cassava NADP-ME gene family and its response and regulation in photosynthesis Open
NADP-malic enzyme (NADP-ME) is a crucial enzyme in C 4 photosynthesis, responsible for the decarboxylation of malate in bundle sheath cells, enhancing the photosynthetic efficiency of C 4 plants. Cultivated cassava exhibits high photosynth…
View article: TropiCODB: A multi-omics resource for supporting biodesign in tropical crops
TropiCODB: A multi-omics resource for supporting biodesign in tropical crops Open
View article: Comparative hormonal and transcriptomic analysis of heat stress responses in cassava and potato
Comparative hormonal and transcriptomic analysis of heat stress responses in cassava and potato Open
View article: Chromosome-level genome of <i>Spathodea campanulata</i> revealed genetic characteristics of malvidin and cyanidin accumulation in the corolla
Chromosome-level genome of <i>Spathodea campanulata</i> revealed genetic characteristics of malvidin and cyanidin accumulation in the corolla Open
View article: Functional analysis of <i>MeFER4</i> in regulating ROS homeostasis during abiotic stress responses in <i>Arabidopsis</i>
Functional analysis of <i>MeFER4</i> in regulating ROS homeostasis during abiotic stress responses in <i>Arabidopsis</i> Open
View article: HBIcloud: A comprehensive, user-centric platform for integrative multi-omics analysis
HBIcloud: A comprehensive, user-centric platform for integrative multi-omics analysis Open
The rapid expansion of multi-omics data has revolutionized biological research but introduced significant challenges in data integration and analysis, particularly for researchers without advanced computational expertise. HBIcloud addresse…
View article: MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava
MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava Open
The high content of cyanogenic glycosides (CG) in cassava tubers affects food safety. CG are involved in the plant growth and development and protect cassava leaves from herbivorous predators. However, the regulatory mechanism of CG biosyn…
View article: Advancements and strategies of genetic improvement in cassava (<i>Manihot esculenta</i> Crantz): from conventional to genomic approaches
Advancements and strategies of genetic improvement in cassava (<i>Manihot esculenta</i> Crantz): from conventional to genomic approaches Open
Cassava (Manihot esculenta Crantz) is a staple food of 800 million people in the tropical and subtropical regions of the world. Its industrial utilization for bioethanol, animal feed, and starch are still continuously expanding. It was not…
View article: The impact of lymph node involvement on adjuvant chemotherapy and survival in patients with resected invasive intraductal papillary mucinous neoplasm: a propensity score matching study based on SEER database and external validation
The impact of lymph node involvement on adjuvant chemotherapy and survival in patients with resected invasive intraductal papillary mucinous neoplasm: a propensity score matching study based on SEER database and external validation Open
Background: Limited knowledge and guidelines exist for invasive intraductal papillary mucinous neoplasm (IPMN). This study aims to explore the significance of lymph node involvement on adjuvant chemotherapy (ACT) for invasive IPMN. Materia…
View article: 103P Tislelizumab combined with chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: A multicenter, prospective, single-arm, real-world study
103P Tislelizumab combined with chemoradiotherapy for locally advanced esophageal squamous cell carcinoma: A multicenter, prospective, single-arm, real-world study Open
View article: Feasibility Evaluation of I–Shaped Horizontal Salt Cavern for Underground Natural Gas Storage
Feasibility Evaluation of I–Shaped Horizontal Salt Cavern for Underground Natural Gas Storage Open
Underground salt cavern gas storage has been widely applied due to its numerous advantages. Most of China’s salt resources are derived from lacustrine deposits. As high–quality resources in the central sedimentary area are gradually exploi…
View article: not-yet-known not-yet-known not-yet-known unknown Chromosomal reference genome of Merremia boisiana: Unveiling the Secrets of the Tropical Rainforest’s Killer Plant
not-yet-known not-yet-known not-yet-known unknown Chromosomal reference genome of Merremia boisiana: Unveiling the Secrets of the Tropical Rainforest’s Killer Plant Open
View article: HBIcloud: An Integrative Multi-Omics Analysis Platform
HBIcloud: An Integrative Multi-Omics Analysis Platform Open
As biological datasets have grown exponentially in size and complexity, there has been an increasing need for integrative tools that can handle diverse data types and facilitate comprehensive analyses. Traditional methods often require sig…
View article: HortDB V1.0: a genomic database of horticultural plants
HortDB V1.0: a genomic database of horticultural plants Open
View article: Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits
Construction of an ultrahigh-density genetic linkage map for Manihot esculenta Crantz and identification of QTL for root quantity traits Open
Single plant root weight, root number, and root length to width ratio are important agronomic traits that affect cassava yield. To explore the QTL related to quantitative traits such as cassava root weight, this study used Hyper-seq simpli…
View article: Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC)
Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC) Open
Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with increasing incidences worldwide. The overall 5-year survival rate remains low, underscoring the urgent need for effective therapies. Despite the promising efficacy of immunoth…
View article: Transcriptomics Identifies Differentially Expressed Genes Inducing Tuber Formation in Early- and Late-Maturing Potatoes
Transcriptomics Identifies Differentially Expressed Genes Inducing Tuber Formation in Early- and Late-Maturing Potatoes Open
The timing of potato tuberization is affected by potato ripeness, environmental factors, and polygene regulation. The accurate control of the transition to tuberization has both scientific and practical production value, but the key factor…