David Borchelt
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View article: Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits
Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits Open
The Apolipoprotein E (APOE) isoforms APOE2, APOE3 and APOE4 differentially modulate risk of Alzheimer's disease (AD). Despite established evidence for APOE's impact on Aβ deposition, the differential effects of APOE genotypes on distinct f…
View article: Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity
Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity Open
The unfolded protein response sensor PERK exists in haplotypes A and B. PERK-B confers increased risk for tauopathies like progressive supranuclear palsy (PSP), but the mechanisms distinguishing its function from PERK-A and contributing to…
View article: Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease Open
View article: Human<i>APOE</i>allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse<i>Apoe</i>in transgenic mouse models of Alzheimer amyloidosis
Human<i>APOE</i>allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse<i>Apoe</i>in transgenic mouse models of Alzheimer amyloidosis Open
Background Apolipoprotein E (apoE) modulates the deposition of amyloid β (Aβ) aggregates in Alzheimer’s disease (AD) in an isoform-dependent manner. In transgenic mouse models of AD-amyloidosis, replacing mouse Apoe alleles with human APOE…
View article: Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation
Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation Open
The two most prominent post-translational modifications of pathologic tau are Ser/Thr/Tyr phosphorylation and Lys acetylation. Whether acetylation impacts the susceptibility of tau to templated seeding in diseases like Alzheimer’s disease …
View article: Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model Open
View article: Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer’s Disease
Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer’s Disease Open
We report a highly significant correlation between human Alzheimer’s disease (AD) brain proteome changes and those in CRND8 APP695NL/F transgenic mice. Comparing protein changes observed in the CRND8 mice with co-expression networks derive…
View article: Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau Open
View article: Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice
Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice Open
Mutations in superoxide dismutase 1 (SOD1) that are associated with amyotrophic lateral sclerosis (ALS) cause its misfolding and aggregation. Prior studies have demonstrated that the misfolded conformation of ALS-SOD1 can template with naï…
View article: Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis Open
View article: Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy Open
Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging. To provide insights into whether APOE4 genotype is related to tau-associate…
View article: Assessment of levamisole HCl and thymosin α1 in two mouse models of amyotrophic lateral sclerosis
Assessment of levamisole HCl and thymosin α1 in two mouse models of amyotrophic lateral sclerosis Open
Amyotrohpic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes generalized muscle weakness and atrophy. Neuropathologically, ALS is defined by severe loss of upper and lower motor neurons with a robust neuroinfl…
View article: Assessment of Levamisole HCl and Thymosin α1 in Two Mouse Models of Amyotrophic Lateral Sclerosis
Assessment of Levamisole HCl and Thymosin α1 in Two Mouse Models of Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes generalized muscle weakness and atrophy. Neuropathologically, ALS is defined by severe loss of upper and lower motor neurons with a robust neuroinfl…
View article: Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease
Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer’s Disease Open
The amyloid pathology characteristic of Alzheimer’s disease (AD) can be broadly classified as either fibrillary amyloid or diffuse amyloid. Fibrillary amyloid is found in cored-neuritic deposits, fibrillar deposits, and vascular deposits, …
View article: Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice Open
View article: Impact of APOE genotype on prion-type propagation of tauopathy
Impact of APOE genotype on prion-type propagation of tauopathy Open
Apolipoprotein (APOE) is a major risk factor of Alzheimer’s disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau. In AD, pathological tau is thought…
View article: TAPPing into the potential of inducible tau/APP transgenic mice
TAPPing into the potential of inducible tau/APP transgenic mice Open
Aims Our understanding of the pathological interactions between amyloidosis and tauopathy in Alzheimer's disease is incomplete. We sought to determine if the relative timing of the amyloidosis and tauopathy is critical for amyloid‐enhanced…
View article: Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis
Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis Open
View article: Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts
Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts Open
Background: Seeding of pathology related to Alzheimer’s disease (AD) and Lewy body disease (LBD) by tissue homogenates or purified protein aggregates in various model systems has revealed prion-like properties of these disorders. Typically…
View article: Soluble Brain Homogenates from Diverse Human and Mouse Sources Preferentially Seed Diffuse Aβ Plaque Pathology When Injected into Newborn Mouse Hosts
Soluble Brain Homogenates from Diverse Human and Mouse Sources Preferentially Seed Diffuse Aβ Plaque Pathology When Injected into Newborn Mouse Hosts Open
Background Seeding of pathology related to Alzheimer’s disease (AD) and Lewy body disease (LBD) by the injection of tissue homogenates, purified proteins, or recombinant proteins into model systems has revealed prion-like seeding of the pr…
View article: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model
Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model Open
View article: Astrocytic apoE4 and tau: Deadly combination for neurons
Astrocytic apoE4 and tau: Deadly combination for neurons Open
View article: Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence Open
Misfolded forms of superoxide dismutase 1 (SOD1) with mutations associated with familial amyotrophic lateral sclerosis (fALS) exhibit prion characteristics, including the ability to act as seeds to accelerate motor neuron disease in mouse …
View article: Il-10 signaling reduces survival in mouse models of synucleinopathy
Il-10 signaling reduces survival in mouse models of synucleinopathy Open
View article: Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the <scp>APPswePS1dE9</scp> mouse model
Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the <span>APPswePS1dE9</span> mouse model Open
Astrocytes regulate synaptic communication and are essential for proper brain functioning. In Alzheimer's disease (AD) astrocytes become reactive, which is characterized by an increased expression of intermediate filament proteins and cell…
View article: Remodeling Alzheimer-amyloidosis models by seeding
Remodeling Alzheimer-amyloidosis models by seeding Open
View article: Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis Open
View article: Building a Case for Withaferin A as a Treatment for FTD/ALS Syndromes
Building a Case for Withaferin A as a Treatment for FTD/ALS Syndromes Open
View article: Additional file 1 of Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence
Additional file 1 of Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence Open
Additional file 1. Excel spreadsheet that lists all of the transgenic animals, and a subset of the nontransgenic animals, used in this study, with details on the inoculum injected and incubation period postinjection. See Supplementary Mate…
View article: Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates
Novel SOD1 monoclonal antibodies against the electrostatic loop preferentially detect misfolded SOD1 aggregates Open