Quancheng Kan
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View article: A Single-cell and Spatially Resolved Cell Atlas of Human Esophageal Squamous Cell Carcinoma
A Single-cell and Spatially Resolved Cell Atlas of Human Esophageal Squamous Cell Carcinoma Open
Tumor heterogeneity and the suppressive microenvironment are key challenges that limit the effectiveness of cancer treatment. In this study, we systematically elucidated the molecular characteristics and mechanisms underlying the suppressi…
View article: The effectiveness and safety of azvudine treatment in COVID‐19 patients with kidney disease based on a multicenter retrospective cohort study
The effectiveness and safety of azvudine treatment in COVID‐19 patients with kidney disease based on a multicenter retrospective cohort study Open
Kidney disease has been the main risk factor of poor prognosis for COVID‐19 patients. The effectiveness and safety of azvudine treatment in COVID‐19 patients with kidney disease have not been reported. Herein, we conducted a nine‐center an…
View article: METTL1/WDR4-mediated m<sup>7</sup>G Hypermethylation of SCLT1 mRNA Promotes Gefitinib Resistance in Non-small Cell Lung Cancer
METTL1/WDR4-mediated m<sup>7</sup>G Hypermethylation of SCLT1 mRNA Promotes Gefitinib Resistance in Non-small Cell Lung Cancer Open
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have produced durable complete responses, but the eventual development of acquired resistance presents a huge challenge in the treatment of non-small cell lung cancer …
View article: Effectiveness and Safety of Oral Azvudine for Elderly Hospitalized Patients With COVID‐19: A Multicenter, Retrospective, Real‐World Study
Effectiveness and Safety of Oral Azvudine for Elderly Hospitalized Patients With COVID‐19: A Multicenter, Retrospective, Real‐World Study Open
Azvudine is recommended as a priority treatment for patients with Coronavirus Disease 2019 (COVID‐19) during Omicron wave in China, but its efficacy and safety in elderly patients is unknown. In this multicenter, retrospective study, we id…
View article: Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway
Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway Open
Introduction Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and …
View article: A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years
A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years Open
Azvudine and nirmatrelvir/ritonavir (Paxlovid) are recommended for COVID-19 treatment in China, but their safety and efficacy in the elderly population are not fully known. In this multicenter, retrospective, cohort study, we identified 51…
View article: NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation
NSUN2/YBX1 promotes the progression of breast cancer by enhancing HGH1 mRNA stability through m5C methylation Open
Background RNA m 5 C methylation has been extensively implicated in the occurrence and development of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across diverse tumor types. However, the precise impact of N…
View article: Single-Cell and Spatial Resolved Multi-Omics Decipher the Interactions of Col17a1+ Tumor and Postn+ Fibroblasts in Esophageal Squamous Cell Carcinoma
Single-Cell and Spatial Resolved Multi-Omics Decipher the Interactions of Col17a1+ Tumor and Postn+ Fibroblasts in Esophageal Squamous Cell Carcinoma Open
View article: ·A Retrospective Cohort Study of the Efficacy and Safety of Oral Azvudine Versus Paxlovid in Elderly Hospitalized COVID-19 Patients Aged Over 60 Years
·A Retrospective Cohort Study of the Efficacy and Safety of Oral Azvudine Versus Paxlovid in Elderly Hospitalized COVID-19 Patients Aged Over 60 Years Open
View article: Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer Open
Background RNA 5-methylcytosine (m 5 C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m 5 C modification in tumor drug resistance remain unclear. Methods The c…
View article: RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling <i>YRDC</i> Translation in NSCLC Cells
RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling <i>YRDC</i> Translation in NSCLC Cells Open
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control of non-small cell lung cancer (NSCLC). Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful treatment. Howeve…
View article: Corrigendum to “Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune Encephalomyelitis.” [Experimental and Molecular Pathology. 2014; 97(3):470–6. doi: 10.1016/j.yexmp.2014.10.004.]
Corrigendum to “Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune Encephalomyelitis.” [Experimental and Molecular Pathology. 2014; 97(3):470–6. doi: 10.1016/j.yexmp.2014.10.004.] Open
View article: RNA structural dynamics modulate EGFR-TKIs resistance through controlling<i>YRDC</i>translation in NSCLC cells
RNA structural dynamics modulate EGFR-TKIs resistance through controlling<i>YRDC</i>translation in NSCLC cells Open
SUMMARY Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control of non-small cell lung cancer (NSCLC). The rapidly acquired TKIs resistance accounts for a major hurdle in successful tre…
View article: Correction to: Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity
Correction to: Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity Open
View article: NSUN2-Mediated mRNA m <b>5</b> C Modification Regulates the Progression of Hepatocellular Carcinoma
NSUN2-Mediated mRNA m <b>5</b> C Modification Regulates the Progression of Hepatocellular Carcinoma Open
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors. However, its characteristics and functions in hepatocellular carcinoma (HC…
View article: Development and Verification of a Combined Immune- and Metabolism-Related Prognostic Signature for Hepatocellular Carcinoma
Development and Verification of a Combined Immune- and Metabolism-Related Prognostic Signature for Hepatocellular Carcinoma Open
Immune escape and metabolic reprogramming are becoming important characteristics of tumor biology, which play critical roles in tumor initiation and progression. However, the integrative analysis of immune and metabolic characteristics for…
View article: NSUN2-mediated mRNA m<sup>5</sup>C Modification Regulates the Progression of Hepatocellular Carcinoma
NSUN2-mediated mRNA m<sup>5</sup>C Modification Regulates the Progression of Hepatocellular Carcinoma Open
RNA modification affects many biological processes and physiological diseases. The 5-methylcytosine (m 5 C) modification regulates the progression of multiple tumors. However, its characteristics and functions in hepatocellular carcinoma (…
View article: The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma
The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma Open
Immunotherapy, closely associated with immune infiltration and tumor mutation burden (TMB), is emerging as a promising strategy for treating tumors, but its low response rate in hepatocellular carcinoma (HCC) remains a major challenge. Her…
View article: Metformin attenuated sepsis-related liver injury by modulating gut microbiota
Metformin attenuated sepsis-related liver injury by modulating gut microbiota Open
Increased evidence shows that gut microbiota acts as the primary regulator of the liver; however, its role in sepsis-related liver injury (SLI) in the elderly is unclear. This study assessed whether metformin could attenuate SLI by modulat…
View article: MiR-93-5p regulates tumorigenesis and tumor immunity by targeting PD-L1/CCND1 in breast cancer
MiR-93-5p regulates tumorigenesis and tumor immunity by targeting PD-L1/CCND1 in breast cancer Open
Taken together, miR-93-5p could regulate tumorigenesis and tumor immunity by targeting PD-L1/CCND1 in BRCA and our research provides a rationale for therapy with miR-93-5p to overcome immune escape and improve risk stratifica…
View article: High miR‑3609 expression is associated with better prognosis in TNBC based on mining using systematic integrated public sequencing data
High miR‑3609 expression is associated with better prognosis in TNBC based on mining using systematic integrated public sequencing data Open
MicroRNAs (miRNAs/miRs) are small endogenous RNAs that regulate gene expression post-transcriptionally. Abnormal miR-3609 expression is associated with the occurrence of pancreatic cancer, glioma and other diseases, such as polycystic ovar…
View article: Corrigendum: Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis
Corrigendum: Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis Open
[This corrects the article DOI: 10.3389/fimmu.2021.709155.].
View article: Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis
Corticosteroids for Treating Sepsis in Adult Patients: A Systematic Review and Meta-Analysis Open
Objective Corticosteroids are a common option used in sepsis treatment. However, the efficacy and potential risk of corticosteroids in septic patients have not been well assessed. This review was performed to assess the efficacy and safety…
View article: RNA N6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications
RNA N6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications Open
Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N 6 -methyladenosine (m 6 A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNA…
View article: Association Between Prior Calcium Channel Blocker Use and Mortality in Septic Patients: A Meta-Analysis of Cohort Studies
Association Between Prior Calcium Channel Blocker Use and Mortality in Septic Patients: A Meta-Analysis of Cohort Studies Open
Background: The aim of this study was to comprehensively review the literature and synthesize the evidence concerning the relationship between prior calcium channel blocker (CCB) use and mortality in patients with sepsis. Methods: The Medi…
View article: Corticosteroids Had no Effect on 28-Days Mortality in Adult Patients with sepsis: A Systematic Review and Meta-Analysis
Corticosteroids Had no Effect on 28-Days Mortality in Adult Patients with sepsis: A Systematic Review and Meta-Analysis Open
Objective: Corticosteroids are a common option used in the treatment of sepsis. However, the efficacy and potential risk of corticosteroids in septic patients have not been well assessed. We performed this review to assess the efficacy and…
View article: Alterations in the human oral and gut microbiomes and lipidomics in COVID-19
Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 Open
Objective To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore …
View article: Association between intake of sweetened beverages with all-cause and cause-specific mortality: a systematic review and meta-analysis
Association between intake of sweetened beverages with all-cause and cause-specific mortality: a systematic review and meta-analysis Open
Background Conclusions remain controversial between the consumption of sugar and artificially sweetened beverages (SSBs and ASBs) and mortality. Methods We systematically searched the PubMed, Embase, Cochrane Library and Web of Science dat…
View article: Involvement of long non‐coding RNAs in the progression of esophageal cancer
Involvement of long non‐coding RNAs in the progression of esophageal cancer Open
Esophageal cancer (EC) is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide. Therefore, exploring the pathogenesis of EC and searching for new targeted therapies are the curren…
View article: Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3 Open