Quanwu Zhang
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View article: Societal Costs and Efficiency of Subcutaneous versus Intravenous Lecanemab in Early Alzheimer’s Disease: A U.S. Cost Comparison Model
Societal Costs and Efficiency of Subcutaneous versus Intravenous Lecanemab in Early Alzheimer’s Disease: A U.S. Cost Comparison Model Open
Subcutaneous lecanemab administration potentially offers substantial societal savings by lowering treatment costs, minimizing time demands, and relieving QOL burdens for patients and caregivers. These findings underscore the potential valu…
View article: Bridging the gap: A conversion framework for CDR-SB and MoCA scores in Alzheimer's disease and related dementia
Bridging the gap: A conversion framework for CDR-SB and MoCA scores in Alzheimer's disease and related dementia Open
This study provides the first validated, bidirectional CDR-SB-MoCA crosswalk, supporting data harmonization and consistent interpretation of cognitive severity across research and clinical settings.
View article: Feasibility of Identifying Acute Nontraumatic Intracerebral Hemorrhage Events Using Diagnostic Coding Among Veterans with Mild Cognitive Impairment or Alzheimer’s Dementia
Feasibility of Identifying Acute Nontraumatic Intracerebral Hemorrhage Events Using Diagnostic Coding Among Veterans with Mild Cognitive Impairment or Alzheimer’s Dementia Open
View article: Patient journey and decision processes for anti-amyloid therapy in Alzheimer’s disease
Patient journey and decision processes for anti-amyloid therapy in Alzheimer’s disease Open
Introduction We utilized the Veterans Affairs Healthcare System administrative database to study the clinical decision-making processes for anti-amyloid therapy (AAT). Methods Patients with clinical notes mentioning lecanemab were identifi…
View article: American's overall and equity-based societal valuation of a disease-modifying Alzheimer's treatment: Results from a discrete choice experiment
American's overall and equity-based societal valuation of a disease-modifying Alzheimer's treatment: Results from a discrete choice experiment Open
While Americans value universal access to an AD treatment highly, health equity considerations did not significantly alter respondents' WTP.
View article: Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries
Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries Open
View article: Total Healthcare Costs across the Alzheimer’s Disease Continuum in the United States (US)
Total Healthcare Costs across the Alzheimer’s Disease Continuum in the United States (US) Open
Background This study describes the total healthcare costs integrating direct, indirect, and intangible or emotional cost components across the severity stages of Alzheimer’s disease (AD) in US. Method Utilizing Health and Retirement Study…
View article: Trajectories in Care Among Veterans with Alzheimer’s Disease in the United States
Trajectories in Care Among Veterans with Alzheimer’s Disease in the United States Open
Objective Few studies have investigated trajectories in care among patients with Alzheimer’s Disease (AD), especially Veterans who experience a unique set of AD risk factors and challenges in access to AD immunotherapy in the Veterans Affa…
View article: Usage Patterns of Anticoagulant Therapy in Patients with Mild Cognitive Impairment or Alzheimer’s Disease
Usage Patterns of Anticoagulant Therapy in Patients with Mild Cognitive Impairment or Alzheimer’s Disease Open
Background This study aims to describe usage patterns and risk factors associated with anticoagulant therapy in patients with mild cognitive impairment (MCI) or Alzheimer’s disease (AD). Methods The United States Medicare claims database (…
View article: Validation of ICD‐10 diagnosis codes for identification of veterans with intracerebral hemorrhage and subarachnoid hemorrhage using clinical notes in the United States Veterans Affairs Healthcare System
Validation of ICD‐10 diagnosis codes for identification of veterans with intracerebral hemorrhage and subarachnoid hemorrhage using clinical notes in the United States Veterans Affairs Healthcare System Open
Background Cerebral amyloid angiopathy (CAA) is a significant contributor to hemorrhagic stroke, notably lobar intracerebral hemorrhage (ICH) and convexity subarachnoid hemorrhage (SAH). This study describes the natural occurrence of ICH a…
View article: All‐cause mortality among veterans with mild cognitive impairment and Alzheimer’s dementia who have Intracerebral hemorrhage and subarachnoid hemorrhage
All‐cause mortality among veterans with mild cognitive impairment and Alzheimer’s dementia who have Intracerebral hemorrhage and subarachnoid hemorrhage Open
Background Cerebral amyloid angiopathy (CAA) is a significant contributor to hemorrhagic stroke, notably lobar intracerebral hemorrhage (ICH) and convexity subarachnoid hemorrhage (SAH), both of which have been observed in patients with MC…
View article: Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer’s Disease: A Systematic Review
Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer’s Disease: A Systematic Review Open
Mild cognitive impairment (MCI) and Alzheimer's disease (AD) have a profound impact on patients' quality of life (QoL), with progressive declines occurring as the disease advances. This systematic review aims to summarize the published evi…
View article: Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression Open
View article: Prevalence of Mild Cognitive Impairment and Alzheimer’s Disease Identified in Veterans in the United States
Prevalence of Mild Cognitive Impairment and Alzheimer’s Disease Identified in Veterans in the United States Open
Background: Diagnostic codes can be instrumental for case identification in Alzheimer’s disease (AD) research; however, this method has known limitations and cannot distinguish between disease stages. Clinical notes may offer more detailed…
View article: Assessing Quality of Life, Economic Burden, and Independence Across the Alzheimer’s Disease Continuum Using Patient-Caregiver Dyad Surveys
Assessing Quality of Life, Economic Burden, and Independence Across the Alzheimer’s Disease Continuum Using Patient-Caregiver Dyad Surveys Open
Background: Alzheimer’s disease (AD) and mild cognitive impairment (MCI) have negative quality of life (QoL) and economic impacts on patients and their caregivers and may increase along the disease continuum from MCI to mild, moderate, and…
View article: Human-Induced Vibration Control of Floor Structures Using MTMD System Optimized by MATLAB-SAP2000 Interface
Human-Induced Vibration Control of Floor Structures Using MTMD System Optimized by MATLAB-SAP2000 Interface Open
Under human-induced excitations, a floor structure may suffer excessive vibrations due to its large span and low damping ratio. Vertical vibrations, in particular, can become intolerable during resonance events. A tuned mass damper (TMD) i…
View article: Prevalence and Severity Distribution of Alzheimer’s Disease in the United States from the Health and Retirement Study
Prevalence and Severity Distribution of Alzheimer’s Disease in the United States from the Health and Retirement Study Open
Background There is limited data regarding Alzheimer’s disease (AD) prevalence by severity across the AD continuum. This study aimed to estimate prevalence of mild cognitive impairment (MCI) and mild, moderate, and severe AD in a represent…
View article: Identification of Alzheimer’s disease in Veteran patients using clinical notes from electronic health records
Identification of Alzheimer’s disease in Veteran patients using clinical notes from electronic health records Open
Background There are challenges in studying and monitoring Alzheimer’s disease (AD) in large patient populations. Clinicians often have insufficient availability of resources to make the diagnosis (e.g. brain scanning, referral to speciali…
View article: Development and validation of a natural language processing system that extracts cognitive test results from clinical notes
Development and validation of a natural language processing system that extracts cognitive test results from clinical notes Open
Background Cognitive test results from electronic health records (EHRs) are key information for assessing the severity and progression of patients with mild cognitive impairment (MCI) and Alzheimer’s’ disease (AD). However, such informatio…
View article: Incidence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population
Incidence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population Open
Background Alzheimer’s disease (AD) is a chronic, neurodegenerative condition. Mild cognitive impairment (MCI) is characterized by cognitive decline, without dementia. We aimed to estimate the incidence of AD and MCI among Medicare benefic…
View article: Comparative identification of Veterans with mild cognitive impairment or Alzheimer’s disease extracted from clinical notes and administrative data
Comparative identification of Veterans with mild cognitive impairment or Alzheimer’s disease extracted from clinical notes and administrative data Open
Background Registries that identify people with mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) will be critical in targeting interventions to delay disease progression. Optimal methods to identify people for inclusion in such…
View article: Diagnosis of Severity of Alzheimer’s Disease from Clinical notes in the Veterans Affairs Healthcare System
Diagnosis of Severity of Alzheimer’s Disease from Clinical notes in the Veterans Affairs Healthcare System Open
Background Alzheimer’s disease (AD) typically progresses in three stages: mild, moderate, and severe. Early detection improves patient care related to identification of suitable interventions and end‐of‐life planning. However, AD severity …
View article: Building a neuropsychiatric testing database for veterans with mild cognitive impairment and Alzheimer’s disease with unstructured electronic health records
Building a neuropsychiatric testing database for veterans with mild cognitive impairment and Alzheimer’s disease with unstructured electronic health records Open
Background Information on clinical decision making and disease severity assessments for mild cognitive impairment (MCI) or Alzheimer’s dementia (AD) typically only exists in medical notes. In this study, we present the methodology of const…
View article: Estimating the prevalence of mild cognitive impairment from clinical notes in U.S. Veterans
Estimating the prevalence of mild cognitive impairment from clinical notes in U.S. Veterans Open
Background Individuals with mild cognitive impairment (MCI), a noticeable decline in cognitive abilities, are at increased risk of developing Alzheimer’s disease (AD) or other dementia. Risk factors for dementia, such as obesity, stroke, d…
View article: Prevalence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population
Prevalence of Alzheimer’s disease (AD) dementia and mild cognitive impairment (MCI) in the United States Medicare population Open
Background Alzheimer’s disease (AD) is a chronic, neurodegenerative health condition. Mild cognitive impairment (MCI) is characterized by cognitive decline, without dementia. We aimed to estimate the prevalence of AD and MCI among Medicare…
View article: Rule-Based Identification of Individuals with Mild Cognitive Impairment or Alzheimer’s Disease Using Clinical Notes from the United States Veterans Affairs Healthcare System
Rule-Based Identification of Individuals with Mild Cognitive Impairment or Alzheimer’s Disease Using Clinical Notes from the United States Veterans Affairs Healthcare System Open
Clinical note-based identification captured more Veterans recorded with MCI and AD than diagnostic code-based identification.
View article: Prognostic significance of MALAT1 in clear cell renal cell carcinoma based on TCGA and GEO
Prognostic significance of MALAT1 in clear cell renal cell carcinoma based on TCGA and GEO Open
Long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) can regulate tumorigenesis and progression of various cancers. However, there is little known about the tumor biology and regulatory mechanism of MALAT1 in…
View article: Assessing out-of-pocket expenses and indirect costs for the Alzheimer disease continuum in the United States
Assessing out-of-pocket expenses and indirect costs for the Alzheimer disease continuum in the United States Open
BACKGROUND: The societal costs of Alzheimer disease (AD) are considerable. Cost data stratified by cost category (direct and indirect) and AD severity in the United States are limited. OBJECTIVE: To describe out-of-pocket (OO…
View article: A Systematic Review of Clinical Practice Guidelines for Alzheimer’s Disease and Strategies for Future Advancements
A Systematic Review of Clinical Practice Guidelines for Alzheimer’s Disease and Strategies for Future Advancements Open
View article: Understanding the impact of social stigma on the patient journey in Alzheimer’s disease through social media narratives
Understanding the impact of social stigma on the patient journey in Alzheimer’s disease through social media narratives Open
Background Patients living with Alzheimer’s disease (AD) and their caregivers/health care providers (HCP) recognize the importance of social stigma; however, traditional surveys do not capture nuances of experienced stigma. We sought to sy…