Boris B. Quednow
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View article: Age disparities in adverse reactions of drugs used in pain therapies in Switzerland
Age disparities in adverse reactions of drugs used in pain therapies in Switzerland Open
Pain therapies are prescribed to a significant proportion of the population but also associated with adverse drug reactions (ADRs). The prescription of pain therapies requires careful consideration of their safety profiles in the context o…
View article: Endocannabinoid response to social stress in chronic non-medical prescription opioid users
Endocannabinoid response to social stress in chronic non-medical prescription opioid users Open
Rationale The ongoing global opioid crisis underscores the need to better understand the neurobiological mechanisms underlying opioid use disorder (OUD). Stress is a key risk factor for developing and maintaining OUD. While animal models r…
View article: Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity
Increased cocaine self-administration and prefrontal cortical dysregulation of glutamatergic and GABAergic signaling in a rat model for sensory processing sensitivity Open
While all organisms are tuned to the environment, some are more sensitive than others. In humans, this is reflected by the trait sensory processing sensitivity (SPS), comprising 20-30% of the population, which is characterized by heightene…
View article: Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities
Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities Open
Regular recreational use of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) has been consistently linked to verbal memory dysfunctions, whose neurobiological origins remain unclear. Although neurochemical, structural, and functional al…
View article: Computational Markers of Altered Social Interaction and Cognition in Methamphetamine Use Disorder
Computational Markers of Altered Social Interaction and Cognition in Methamphetamine Use Disorder Open
Computational modeling of a 10-trial trust game in 49 individuals with methamphetamine use disorder (IMUD) and 49 non-user controls revealed higher irritation, lower guilt, and reduced Theory of Mind in IMUD. These traits did not affect th…
View article: A systematic review of pharmacological effects on human aversive memory
A systematic review of pharmacological effects on human aversive memory Open
A large body of work has investigated the effect of various pharmacological compounds on aversive memory formation, retrieval, and modification in humans. A broad overview across signalling pathways and memory models is currently lacking. …
View article: Differential alterations in peripheral tryptophan pathways in methamphetamine versus MDMA users are linked to their contrasting psychiatric symptoms
Differential alterations in peripheral tryptophan pathways in methamphetamine versus MDMA users are linked to their contrasting psychiatric symptoms Open
Methamphetamine (METH, “Crystal Meth”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) are two types of substituted amphetamines that share structural-chemical similarities but exhibit contrasting acute and chronic effects includin…
View article: Global Increases in Brain Glucose Metabolism Following Acute N,N-Dimethyltryptamine and Harmine Administration in Healthy Volunteers: An [¹⁸F]FDG-PET Study
Global Increases in Brain Glucose Metabolism Following Acute N,N-Dimethyltryptamine and Harmine Administration in Healthy Volunteers: An [¹⁸F]FDG-PET Study Open
Classical psychedelics such N,N -dimethyltryptamine (DMT), psilocybin, and lysergic acid diethylamide (LSD) modulate consciousness via serotonergic receptor agonism, and are increasingly investigated for their psychotherapeutic potential. …
View article: Inhalational nitrous oxide as a transdiagnostic approach for the treatment of suicidal ideation and suicidality in psychiatric inpatients: protocol for a double-blind randomised, controlled clinical single-centre trial
Inhalational nitrous oxide as a transdiagnostic approach for the treatment of suicidal ideation and suicidality in psychiatric inpatients: protocol for a double-blind randomised, controlled clinical single-centre trial Open
Introduction Suicidal thoughts and behaviours are linked to a wide range of mental health conditions. New interest in the psychiatric benefits of nitrous oxide (N 2 O) has only recently emerged. The broad pharmacological effects of N 2 O a…
View article: Relations of problematic online dating app use with mental and sexual health: a cross-sectional study in Swiss university students
Relations of problematic online dating app use with mental and sexual health: a cross-sectional study in Swiss university students Open
Background The rise of online dating apps (ODAs) has raised concerns about potential mental and sexual health risks, particularly among emerging adults. However, limited research exists on how problematic ODA use and health outcomes are as…
View article: Social cognition and decision‐making in people with methamphetamine use disorder
Social cognition and decision‐making in people with methamphetamine use disorder Open
Background and Aims Impairments in social cognition and social decision‐making play an important role in the disease burden experienced by individuals with methamphetamine use disorder (MUD). They are also assumed to play a role in the vic…
View article: The Role of Day-to-Day Experiences in Predicting Later Suicidal Ideation and Self-Injury in Young Adults
The Role of Day-to-Day Experiences in Predicting Later Suicidal Ideation and Self-Injury in Young Adults Open
Suicidality and self-injury in young adults are major public health concerns. Understanding the day-to-day experiences associated with these issues can help identify early risk and/or protective factors. By combining ecological momentary a…
View article: Adolescent Peer Victimization Through a Trauma Lens: Heightened Startle Response, Increased Pupil Dilation, Elevated Cortisol, and Reduced Heart Rate Variability in Young Adulthood
Adolescent Peer Victimization Through a Trauma Lens: Heightened Startle Response, Increased Pupil Dilation, Elevated Cortisol, and Reduced Heart Rate Variability in Young Adulthood Open
BACKGROUND Adolescent peer victimization (PV) is a prevalent social stressor associated with potential long-term psychological and physiological consequences. Yet, the mechanisms underlying enduring alterations in stress-regulatory systems…
View article: Gamma-hydroxybutyrate to promote slow-wave sleep in major depressive disorder: a randomized crossover trial
Gamma-hydroxybutyrate to promote slow-wave sleep in major depressive disorder: a randomized crossover trial Open
View article: Brain iron load and neuroaxonal vulnerability in adult attention‐deficit hyperactivity disorder
Brain iron load and neuroaxonal vulnerability in adult attention‐deficit hyperactivity disorder Open
Aim Adult attention deficit hyperactivity disorder (ADHD) may be associated with an increased risk of dementia in old age. Here, we investigated the liability for neurodegenerative brain disease in adult ADHD, possibly reflected by increas…
View article: Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study
Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study Open
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydroharmine) monoamine oxidase inhibitors. However, the pharmacological interactions between the…
View article: REPURPOSING OF GAMMA-HYDROXYBUTYRATE IN DEPRESSION: A RANDOMIZED PLACEBO-CONTROLLED PROOF-OF-CONCEPT CLINICAL TRIAL
REPURPOSING OF GAMMA-HYDROXYBUTYRATE IN DEPRESSION: A RANDOMIZED PLACEBO-CONTROLLED PROOF-OF-CONCEPT CLINICAL TRIAL Open
Introduction Gamma-hydroxybutyrate (GHB, clinically administrated as sodium oxybate) is an endogenous GHB/GABAB receptor agonist that regulates important homeostatic functions such as eating, sexual behavior, and the sleep-wake cycle. Its …
View article: Problematic online dating app use and its association with mental and sexual health outcomes in a sample of Men-having-Sex-with-Men
Problematic online dating app use and its association with mental and sexual health outcomes in a sample of Men-having-Sex-with-Men Open
Background and aims Online dating applications (ODAs) are gaining popularity, raising concerns about their potential addictive effects on users' health. The main objective of this study was to investigate the association between problemati…
View article: Improving Rationality by Increasing Attention
Improving Rationality by Increasing Attention Open
View article: Simultaneous Polysubstance Use in Adolescents and Young Adults: Prevalence, Patterns, and Risk Correlates
Simultaneous Polysubstance Use in Adolescents and Young Adults: Prevalence, Patterns, and Risk Correlates Open
View article: Cannabis use is associated with changes in psychological and functional well-being during young adulthood: evidence from self-reports and hair analyses
Cannabis use is associated with changes in psychological and functional well-being during young adulthood: evidence from self-reports and hair analyses Open
Background Cannabis use in young adulthood is common, yet few studies have explored how it predicts changes in psychopathology and functional well-being in community samples. We assessed these links using both self-reported frequency of ca…
View article: Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial
Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial Open
Background Recent interest in the clinical use of psychedelics has highlighted plant-derived medicines like ayahuasca showing rapid-acting and sustainable therapeutic effects in various psychiatric conditions. This traditional Amazonian pl…
View article: The effects of single testosterone administration and stress induction on steroid hormone levels in hair
The effects of single testosterone administration and stress induction on steroid hormone levels in hair Open
Hair steroid analysis is increasingly recognized for its ability to capture cumulative hormone secretion, thought to reflect an individual's response to long-term environmental conditions. Despite its growing use, the influence of single, …
View article: Words versus Strands: Reliability and Stability of Concordance Rates of Self-Reported and Hair-Analyzed Substance Use of Young Adults over Time
Words versus Strands: Reliability and Stability of Concordance Rates of Self-Reported and Hair-Analyzed Substance Use of Young Adults over Time Open
Introduction: Population-level substance use research primarily relies on self-reports, which often underestimate actual use. Hair analyses offer a more objective estimate; however, longitudinal studies examining concordance are lacking. P…
View article: Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices
Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices Open
In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an assumption that may have risen because self‐reports in a forensic setting are of uncertain validity per se. We therefore in…
View article: Acute neuroaxonal remodelling after electroconvulsive treatment in patients with major depressive disorder: A pilot study
Acute neuroaxonal remodelling after electroconvulsive treatment in patients with major depressive disorder: A pilot study Open
View article: Erratum zu: Psychedelika und Dissoziativa in der Psychiatrie: Herausforderungen in der Behandlung
Erratum zu: Psychedelika und Dissoziativa in der Psychiatrie: Herausforderungen in der Behandlung Open
View article: Forget me not: The effect of doxycycline on human declarative memory
Forget me not: The effect of doxycycline on human declarative memory Open
Investigations into neuroprotective drugs are in high demand for the treatment of neurodegenerative diseases, such as multiple sclerosis or Alzheimer's disease, but also psychiatric disorders, such as depression, trauma, and substance use.…
View article: Psychedelika und Dissoziativa in der Psychiatrie: Herausforderungen in der Behandlung
Psychedelika und Dissoziativa in der Psychiatrie: Herausforderungen in der Behandlung Open
View article: Disentangling the effects of self-control and the use of tobacco and cannabis on violence perpetration from childhood to early adulthood
Disentangling the effects of self-control and the use of tobacco and cannabis on violence perpetration from childhood to early adulthood Open