Quentin A. Pankhurst
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View article: Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy
Insight into the Internal Structure of High-Performance Multicore Magnetic Nanoparticles Used in Cancer Thermotherapy Open
Multicore magnetic nanoparticles (MNPs), comprising iron oxide cores embedded in a sugar or starch matrix, are a class of nanomaterials with promising magnetic heating properties. Their internal structure, and particularly the strength of …
View article: Improved tumour delivery of iron oxide nanoparticles for magnetic hyperthermia therapy of melanoma <i>via</i> ultrasound guidance and <sup>111</sup>In SPECT quantification
Improved tumour delivery of iron oxide nanoparticles for magnetic hyperthermia therapy of melanoma <i>via</i> ultrasound guidance and <sup>111</sup>In SPECT quantification Open
We increased the accuracy of tumour nanoparticle delivery using real-time ultrasound imaging and slow syringe-pump controlled infusion. This minimises off-target side effects for better and safer melanoma treatment using magnetic hyperther…
View article: Local Magnetic Hyperthermia and Systemic Gemcitabine/Paclitaxel Chemotherapy Triggers Neo-Angiogenesis in Orthotopic Pancreatic Tumors without Involvement of Auto/Paracrine Tumor Cell VEGF Signaling and Hypoxia
Local Magnetic Hyperthermia and Systemic Gemcitabine/Paclitaxel Chemotherapy Triggers Neo-Angiogenesis in Orthotopic Pancreatic Tumors without Involvement of Auto/Paracrine Tumor Cell VEGF Signaling and Hypoxia Open
There is a growing interest in exploring the therapeutically mediated modulation of tumor vascularization of pancreatic cancer, which is known for its poorly perfused tumor microenvironment limiting the delivery of therapeutic agents to th…
View article: Nonspecific eddy current heating in magnetic field hyperthermia
Nonspecific eddy current heating in magnetic field hyperthermia Open
In this Perspective article, we explore the definition and use of clinical tolerability metrics associated with nonspecific eddy current heating in magnetic field hyperthermia (MFH). We revisit the origins of the “Brezovich criterion,” Hof…
View article: Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System (Adv. Sci. 12/2022)
Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System (Adv. Sci. 12/2022) Open
Minimally Invasive Image‐Guided Ablation Concept An artist's impression of the minimally invasive image‐guided ablation (MINIMA) concept, whereby the magnetic field gradients generated by an MRI scanner are used to navigate a ferromagnetic…
View article: Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System
Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System Open
Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image‐guided remote…
View article: Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation (Adv. Sci. 6/2022)
Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation (Adv. Sci. 6/2022) Open
Magnetomechanical Stimulation Magnetomechanical stimulation enables remote and selective control of brain cell activity without any need for genetic modification. Antibody‐functionalized magnetic particles are targeted to the mechanosensit…
View article: Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation
Remote and Selective Control of Astrocytes by Magnetomechanical Stimulation Open
Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existi…
View article: Prenormative verification and validation of a protocol for measuring magnetite–maghemite ratios in magnetic nanoparticles
Prenormative verification and validation of a protocol for measuring magnetite–maghemite ratios in magnetic nanoparticles Open
An important step in establishing any new metrological method is a prenormative interlaboratory study, designed to verify and validate the method against its stated aims. Here, the 57 Fe Mössbauer spectrometric ‘centre of gravity’ (COG) me…
View article: Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation
Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation Open
Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune activation in the tumor microenvironment whilst sparing surrounding normal tiss…
View article: Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
Deep-tissue localization of magnetic field hyperthermia using pulse sequencing Open
Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more pe…
View article: Challenges and recommendations for magnetic hyperthermia characterization measurements
Challenges and recommendations for magnetic hyperthermia characterization measurements Open
We conclude that the study reveals a current lack of harmonization in MFH characterization of MNPs, and highlights the growing need for standardized, quantitative characterization techniques for this emerging medical technology.
View article: Development of an in-line magnetometer for flow chemistry and its demonstration for magnetic nanoparticle synthesis
Development of an in-line magnetometer for flow chemistry and its demonstration for magnetic nanoparticle synthesis Open
A highly sensitive magnetometer for flow chemistry to characterise magnetic nanoparticles in solution, in situ and in real-time is presented. This facilitates continuous quality control and high-throughput screening of magnetic nanoparticl…
View article: Deep-tissue localization of magnetic field hyperthermia using pulse sequencing
Deep-tissue localization of magnetic field hyperthermia using pulse sequencing Open
Deep-tissue localization of thermal doses is a long-standing challenge in magnetic field hyperthermia (MFH), and remains a limitation of the clinical application of MFH to date. Here, we show that pulse sequencing of MFH leads to a more pe…
View article: Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data
Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data Open
These files contain the raw measurement data reported for the Radiomag interlaboratory comparison of magnetic hyperthermia characterisation measurements. Each heating curve for samples containing magnetic nanoparticles is presented in a se…
View article: Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data
Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data Open
These files contain the raw measurement data reported for the Radiomag interlaboratory comparison of magnetic hyperthermia characterisation measurements. Each heating curve for samples containing magnetic nanoparticles is presented in a se…
View article: Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data
Radiomag Interlaboratory Comparison of Magnetic Hyperthermia Characterisation Measurements: Data Open
These files contain the raw measurement data reported for the Radiomag interlaboratory comparison of magnetic hyperthermia characterisation measurements. Each heating curve for samples containing magnetic nanoparticles is presented in a se…
View article: Radiobiological Implications of Nanoparticles Following Radiation Treatment
Radiobiological Implications of Nanoparticles Following Radiation Treatment Open
Materials with a high atomic number (Z) are shown to cause an increase in the level of cell kill by ionizing radiation when introduced into tumor cells. This study uses in vitro experiments to investigate the differences in radiosensitizat…
View article: Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles
Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles Open
Mineralisation of radio-metals onto the surface of iron oxide nanoparticles simplifies radiolabelling, enabling quantification of their bio-distribution with nuclear imaging.
View article: TMIC-33. POTENTIAL OF MAGNETIC HYPERTHERMIA TO STIMULATE AN IMMUNE RESPONSE IN GLIOBLASTOMA
TMIC-33. POTENTIAL OF MAGNETIC HYPERTHERMIA TO STIMULATE AN IMMUNE RESPONSE IN GLIOBLASTOMA Open
INTRODUCTION: Glioblastoma, the most common primary adult brain malignancy, is an aggressive tumour with a median survival of around one year. Despite decades of research there has been minimal improvement in prognosis and innovative new t…
View article: Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models
Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models Open
We offer a critique of what constitutes a suitable dosage limit, in both clinical and preclinical studies, for interstitially administered magnetic nanoparticles in order to enable therapeutic hyperthermia under the action of an externally…
View article: Standardisation of magnetic nanoparticles in liquid suspension
Standardisation of magnetic nanoparticles in liquid suspension Open
Suspensions of magnetic nanoparticles offer diverse opportunities for technology innovation, spanning a large number of industry sectors from imaging and actuation based applications in biomedicine and biotechnology, through large-scale en…
View article: On the ‘centre of gravity’ method for measuring the composition of magnetite/maghemite mixtures, or the stoichiometry of magnetite-maghemite solid solutions, via<sup>57</sup>Fe Mössbauer spectroscopy
On the ‘centre of gravity’ method for measuring the composition of magnetite/maghemite mixtures, or the stoichiometry of magnetite-maghemite solid solutions, via<sup>57</sup>Fe Mössbauer spectroscopy Open
We evaluate the application of 57Fe Mössbauer spectroscopy to the determination of the
\ncomposition of magnetite (Fe3O4)/maghemite (γ-Fe2O3) mixtures and the stoichiometry
\nof magnetite-maghemite solid solutions. In particular, we consid…
View article: Enhancing the Magnetic Heating Capacity of Iron Oxide Nanoparticles through Their Postproduction Incorporation into Iron Oxide–Gold Nanocomposites
Enhancing the Magnetic Heating Capacity of Iron Oxide Nanoparticles through Their Postproduction Incorporation into Iron Oxide–Gold Nanocomposites Open
Invited for the cover of this issue is the group of Ivan P. Parkin and Quentin A. Pankhurst from University College London, UK, in collaboration with Malini Olivo from A*STAR Singapore Bioimaging Consortium. The cover image shows how nanoc…
View article: Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection
Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection Open
Drug delivery to the gastrointestinal (GI) tract is highly challenging due to the harsh environments any drug- delivery vehicle must experience before it releases it’s drug payload. Effective targeted drug delivery systems often rely on ex…
View article: Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans
Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans Open
A sound theoretical rationale for the design of a magnetic nanocarrier capable of magnetic capture in vivo after intravenous administration could help elucidate the parameters necessary for in vivo magnetic tumor targeting. In this work, w…
View article: Superparamagnetic iron oxide nanoparticles regulate smooth muscle cell phenotype
Superparamagnetic iron oxide nanoparticles regulate smooth muscle cell phenotype Open
Superparamagnetic iron oxide nanoparticles (SPION) are used for an increasing range of biomedical applications, from imaging to mechanical actuation of cells and tissue. The aim of this study was to investigate the loading of smooth muscle…
View article: Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles
Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles Open
Magnetic hyperthermia - a potential cancer treatment in which superparamagnetic iron oxide nanoparticles (SPIONs) are made to resonantly respond to an alternating magnetic field (AMF) and thereby produce heat - is of significant current in…