Quentin Bazot
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View article: The manufacture of AAV for gene therapy applications using a closed, semi-automated hollow-fiber bioreactor
The manufacture of AAV for gene therapy applications using a closed, semi-automated hollow-fiber bioreactor Open
View article: Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection
Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection Open
Hepatitis B virus (HBV) entry into hepatocytes is mediated via a high-affinity interaction between the preS1 glycoprotein and sodium/bile acid cotransporting polypeptide (NTCP). To date, in vitro model systems rely on high multiplicities o…
View article: Requirement for PRC1 subunit BMI1 in host gene activation by Epstein–Barr virus protein EBNA3C
Requirement for PRC1 subunit BMI1 in host gene activation by Epstein–Barr virus protein EBNA3C Open
Epstein-Barr virus proteins EBNA3A, EBNA3B and EBNA3C control hundreds of host genes after infection. Changes in epigenetic marks around EBNA3-regulated genes suggest that they exert transcriptional control in collaboration with epigenetic…
View article: Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of <i>COBLL1</i> and the <i>ADAM28-ADAMDEC1</i> Locus via Interaction with the Histone Lysine Demethylase KDM2B
Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of <i>COBLL1</i> and the <i>ADAM28-ADAMDEC1</i> Locus via Interaction with the Histone Lysine Demethylase KDM2B Open
EBV is a virus associated with human cancers and is well known for its ability to transform B lymphocytes into continuously proliferating lymphoblastoid cell lines. EBNA3C is considered an oncoprotein and has been shown to be essential for…
View article: Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the <i>STK39</i> Gene in B Cells Infected by EBV
Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the <i>STK39</i> Gene in B Cells Infected by EBV Open
Epstein-Barr virus (EBV) establishes latent infection in human B cells and is associated with a wide range of cancers. The EBV nuclear antigen 3 (EBNA3) family proteins are critical for B cell transformation and function as transcriptional…
View article: EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency
EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency Open
Mature human B cells infected by Epstein-Barr virus (EBV) become activated, grow, and proliferate. If the cells are infected ex vivo, they are transformed into continuously proliferating lymphoblastoid cell lines (LCLs) that carry EBV DNA …
View article: Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection Open
Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation. The EBV oncoprotein LMP1 consti…
View article: Author response: Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection
Author response: Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Latent Epstein-Barr virus (EB…
View article: Epstein–Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle
Epstein–Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle Open
The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is a sequence-specific DNA-binding protein that plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of DNA replication onto the ori…
View article: Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression
Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression Open
ChIP-seq performed on lymphoblastoid cell lines (LCLs), expressing epitope-tagged EBNA3A, EBNA3B or EBNA3C from EBV-recombinants, revealed important principles of EBNA3 binding to chromatin. When combined with global chromatin looping data…
View article: EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells
EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells Open
It is well established that Epstein-Barr virus nuclear antigen 3C (EBNA3C) can act as a potent repressor of gene expression, but little is known about the sequence of events occurring during the repression process. To explore further the r…
View article: Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2
Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2 Open
We show that two host-encoded primary RNAs (pri-miRs) and the corresponding microRNA (miR) clusters--widely reported to have cell transformation-associated activity--are regulated by EBNA3A and EBNA3C. Utilising a variety of EBV-transforme…