Quentin R. Johnson
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View article: Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs
Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs Open
Cystic fibrosis (CF) is a recessive genetic disease that is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The recent development of a class of drugs called "correctors", which repair the str…
View article: Data from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Data from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance Open
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells and are largely refractory to immunotherapy. Accordingly, the role of T-cell im…
View article: Supplementary Tables and Figures from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Supplementary Tables and Figures from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance Open
Supplementary Tables 1-7 and Figures 1-17
View article: Data from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Data from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance Open
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells and are largely refractory to immunotherapy. Accordingly, the role of T-cell im…
View article: Supplementary Tables and Figures from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Supplementary Tables and Figures from Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance Open
Supplementary Tables 1-7 and Figures 1-17
View article: An Analysis of Prominent Water Models by Molecular Dynamics Simulations
An Analysis of Prominent Water Models by Molecular Dynamics Simulations Open
Water is the most common solvent for most biological reactions, therefore it is vital that we fully understand water and all its properties. The complex hydrogen bonding network that water forms can influence protein-protein and protein-su…
View article: Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance
Antitumor T-cell Immunity Contributes to Pancreatic Cancer Immune Resistance Open
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells and are largely refractory to immunotherapy. Accordingly, the role of T-cell im…
View article: Immune Selection Pressure Contributes to Pancreatic Cancer Immune Evasion
Immune Selection Pressure Contributes to Pancreatic Cancer Immune Evasion Open
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the United States. Pancreatic tumors are minimally infiltrated by T cells and are largely refractory to immunotherapy. Accordingly, the role of T cell im…
View article: Carotenoids promote lateral packing and condensation of lipid membranes
Carotenoids promote lateral packing and condensation of lipid membranes Open
Carotenoids, pigment molecules that protect biomembranes against degradation, are shown to have similar effects to cholesterol on regulating the behavior of fluid-phase membranes.
View article: Abstract 4584: Malignant pancreatic cancer cells respond to immune selection pressure to foster immunosuppression
Abstract 4584: Malignant pancreatic cancer cells respond to immune selection pressure to foster immunosuppression Open
Background:Host immunity is relevant to pancreatic cancer (PC). Pancreatic tumors are infiltrated with a high number of immune cells, and they play a potential important role in disease evolution. However, there is no FDA approved immunoth…
View article: Effects of carotenoids on lipid bilayers
Effects of carotenoids on lipid bilayers Open
Carotenoids have been found to be important in improving the integrity of biomembranes in eukaryotes.
View article: The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor
The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor Open
The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization and (anti)cooperative binding of cognate ligands. Here, the st…
View article: Investigation of Carbohydrate Recognition via Computer Simulation
Investigation of Carbohydrate Recognition via Computer Simulation Open
Carbohydrate recognition by proteins, such as lectins and other (bio)molecules, can be essential for many biological functions. Recently, interest has arisen due to potential protein and drug design and future bioengineering applications. …
View article: Mapping Allostery through Computational Glycine Scanning and Correlation Analysis of Residue–Residue Contacts
Mapping Allostery through Computational Glycine Scanning and Correlation Analysis of Residue–Residue Contacts Open
Understanding allosteric mechanisms is essential for the physical control of molecular switches and downstream cellular responses. However, it is difficult to decode essential allosteric motions in a high-throughput scheme. A general two-p…