Quentin Leyrolle
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View article: Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study
Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study Open
Saffron extract supplementation do not affect subclinical depressive symptoms, either as a composite score or individual symptom categories. A potential effect on improved mental health outcomes cannot be excluded but requires further repl…
View article: Obesity-induced emotional alterations in mice are associated with impairments of tryptophan metabolism along the kynurenine and indole pathways
Obesity-induced emotional alterations in mice are associated with impairments of tryptophan metabolism along the kynurenine and indole pathways Open
Chronic inflammatory conditions, such as obesity, are frequently associated with a high prevalence of mood disorders and a reduced response to conventional antidepressants. Therefore, identifying the biological substrates underlying these …
View article: Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health
Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health Open
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promisin…
View article: Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach t…
View article: Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Author response: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
View article: Reviewer #1 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Reviewer #1 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Reviewer #2 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Reviewer #2 (Public Review): Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promisin…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to alcohol addiction are not yet fully understood, and in this respect, metabolomics represents a promising approa…
View article: Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder
Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder Open
Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach t…
View article: Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging
Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging Open
Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term m…
View article: The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain
The gut-derived metabolites as mediators of the effect of healthy nutrition on the brain Open
Nutrition is now well recognized to be an environmental factor which positively or negatively influences the risk to develop neurological and psychiatric disorders. The gut microbiota has recently been shown to be an important actor mediat…
View article: Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications
Neurodevelopmental disorders (NDD) without boundaries: research and interventions beyond classifications Open
View article: Erratum to “N‐3 <scp>PUFA</scp> deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development”
Erratum to “N‐3 <span>PUFA</span> deficiency disrupts oligodendrocyte maturation and myelin integrity during brain development” Open
This article corrects the following:N-3 PUFA deficiency disrupts oligodendrocyte maturation and myelin integrity during brain developmentQuentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Brière, Stephane Leon, Ioannis Bakoyiannis, E…
View article: Microbiota-derived metabolites as drivers of gut–brain communication
Microbiota-derived metabolites as drivers of gut–brain communication Open
Alterations in the gut microbiota composition have been associated with a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. The gut microbes transform and metabolize dietary- and host-derived molecules generat…
View article: Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients
Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients Open
Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients. The aim of the study is to…
View article: Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients
Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients Open
Alcohol use disorder (AUD) is a chronic relapsing disease associated with malnutrition, metabolic disturbances, and gut microbiota alterations that are correlated with the severity of psychological symptoms. This study aims at supplementin…
View article: Microbiome and metabolome-related biomarkers of mood alterations in obese patients
Microbiome and metabolome-related biomarkers of mood alterations in obese patients Open
View article: Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner
Microglial Cannabinoid Type 1 Receptor Regulates Brain Inflammation in a Sex-Specific Manner Open
Background: Neuroinflammation is a key feature shared by most, if not all, neuropathologies. It involves complex biological processes that act as a protective mechanism to fight against the injurious stimuli, but it can lead to tiss…
View article: Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice
Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice Open
View article: Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial
Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: A randomized, controlled trial Open
View article: Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain Open
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs.…
View article: Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder
Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder Open
View article: Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients
Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients Open
Non-targeted omics approaches allow to select specific microbial genera and two plasma metabolites that characterize BED obese patients. Further studies are needed to confirm their potential role as drivers or biomarkers of binge eating di…
View article: Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime
Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime Open
View article: Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial
Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial Open
View article: Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients
Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients Open
Objective The gut microbiota has been proposed as an interesting therapeutic target for metabolic disorders. Inulin as a prebiotic has been shown to lessen obesity and related diseases. The aim of the current study was to investigate wheth…
View article: Discovery of the gut microbial signature driving the efficacy of prebiotic intervention on liver steatosis
Discovery of the gut microbial signature driving the efficacy of prebiotic intervention on liver steatosis Open
Introduction : Dietary supplementation with inulin as a prebiotic has been shown to lessen obesity and related metabolic disorders in some individuals. Previous work highlighted the interest of prebiotic supplementation in the management o…