Quentin Vicens
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View article: Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry
Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry Open
Double-stranded nucleic acids can undergo transitions from canonical B/A-forms to alternate left-handed Z-DNA/Z-RNA (Z-NAs). Z-NAs are implicated in processes such as neuroinflammation in Alzheimer’s disease, Lupus Erythematosus, microbial…
View article: Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing
Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing Open
The role of Adenosine Deaminase Acting on RNA 1 (ADAR1)’s Z-conformation stabilizing Zα domain in A-to-I editing is unclear. Previous studies on Zα mutations faced limitations, including variable ADAR1p150 expression, differential editing …
View article: RNAhub—an automated pipeline to search and align RNA homologs with secondary structure assessment
RNAhub—an automated pipeline to search and align RNA homologs with secondary structure assessment Open
The complexity in the generation of RNA multiple sequence alignments and assessment of the accuracy of such alignments contributes to the challenges in the utilization of RNA MSAs in diverse integrative methods. RNAhub is a freely availabl…
View article: RNAhub - an automated pipeline to search and align RNA homologs with secondary structure assessment
RNAhub - an automated pipeline to search and align RNA homologs with secondary structure assessment Open
The complexity in the generation of RNA multiple sequence alignments and assessment of the accuracy of such alignments contributes to the challenges in the utilization of RNA alignments in diverse integrative methods. RNAhub is a freely av…
View article: Tick-borne flavivirus exoribonuclease-resistant RNAs contain a ‘double loop’ structure
Tick-borne flavivirus exoribonuclease-resistant RNAs contain a ‘double loop’ structure Open
Flaviviridae viruses are human pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs) that block progression of host cell’s exoribonucleases. The structures of several xr…
View article: Zα Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity
Zα Domain of ADAR1 Binds to an A-Form-like Nucleic Acid Duplex with Low Micromolar Affinity Open
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA when bound by Zα domains found within a variety of viral and innate immune response proteins. While Z-form adoption is preferred by certain sequences, such …
View article: Abstract 2084 Going from right-handed RNA to left-handed Z-RNA: Gotta unfold first!
Abstract 2084 Going from right-handed RNA to left-handed Z-RNA: Gotta unfold first! Open
Z-RNA is a left-handed double helix first discovered in vitro several decades ago and subsequently shown to exist in vivo. However, its biological significance remained a mystery. Z-RNA has recently regained interest as several laboratorie…
View article: Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate
Z-Form Adoption of Nucleic Acid is a Multi-Step Process Which Proceeds through a Melted Intermediate Open
The left-handed Z-conformation of nucleic acids can be adopted by both DNA and RNA when bound by Zα domains found within a variety of innate immune response proteins. Zα domains stabilize this higher-energy conformation by making specific …
View article: Principles, mechanisms, and biological implications of translation termination–reinitiation
Principles, mechanisms, and biological implications of translation termination–reinitiation Open
The gene expression pathway from DNA sequence to functional protein is not as straightforward as simple depictions of the central dogma might suggest. Each step is highly regulated, with complex and only partially understood molecular mech…
View article: Structure and Formation of Z-DNA and Z-RNA
Structure and Formation of Z-DNA and Z-RNA Open
Despite structural differences between the right-handed conformations of A-RNA and B-DNA, both nucleic acids adopt very similar, left-handed Z-conformations. In contrast to their structural similarities and sequence preferences, RNA and DN…
View article: Z-RNA biology: a central role in the innate immune response?
Z-RNA biology: a central role in the innate immune response? Open
Z-RNA is a higher-energy, left-handed conformation of RNA, whose function has remained elusive. A growing body of work alludes to regulatory roles for Z-RNA in the immune response. Here, we review how Z-RNA features present in cellular RNA…
View article: Brief considerations on targeting RNA with small molecules
Brief considerations on targeting RNA with small molecules Open
For more than three decades, RNA has been known to be a relevant and attractive macromolecule to target but figuring out which RNA should be targeted and how remains challenging. Recent years have seen the confluence of approaches for scre…
View article: Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA
Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA Open
Functional RNAs fold through complex pathways that can contain misfolded “kinetic traps.” A complete model of RNA folding requires understanding the formation of these misfolded states, but they are difficult to characterize because of the…
View article: Thoughts on how to think (and talk) about RNA structure
Thoughts on how to think (and talk) about RNA structure Open
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as both the source and countermeasure to a severe acute respir…
View article: Cryo-EM reveals an entangled kinetic trap in the folding pathway of a catalytic RNA
Cryo-EM reveals an entangled kinetic trap in the folding pathway of a catalytic RNA Open
Functional RNAs fold through complex pathways that can contain misfolded “kinetic traps.” A complete model of RNA folding requires understanding the formation of such misfolded states, but they are difficult to characterize due to their tr…
View article: Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA
Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA Open
It is now difficult to believe that a biological function for the left-handed Z-DNA and Z-RNA conformations was once controversial. The papers in this Special Issue, “Z-DNA and Z-RNA: from Physical Structure to Biological Function”, are ba…
View article: 4 scenarios for online teaching and professional development: concrete examples and practical advice
4 scenarios for online teaching and professional development: concrete examples and practical advice Open
This booklet was specifically written to address issues arising upon the COVID-19 pandemic. The text was originally written in French, before being translated into English by the authors. It contains excerpts from the book entitled Enseign…
View article: Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions
Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions Open
Adenosine-to-inosine (A-to-I) editing of eukaryotic cellular RNAs is essential for protection against auto-immune disorders. Editing is carried out by ADAR1, whose innate immune response-specific cytoplasmic isoform possesses a Z-DNA bindi…
View article: Special Issue: Frontiers in RNA Structure
Special Issue: Frontiers in RNA Structure Open
The frontiers of our knowledge about RNA structure are rapidly moving [...]